Breast Cancer Clinical Research Unit

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Post-Doctoral Fellows

  • Rebeca Gema Jimeno

Graduate Students

  • José Luis Ruiz

The Breast Cancer Clinical Research Unit (BCCRU) focuses on the translational interface of therapeutic development. Breast cancer is a heterogeneous disease, and thus, there are large inter-patient variations in terms of disease course, prognosis, relapse and resistance to conventional or targeted therapeutics.

Our activities are directed towards personalised treatment and range from preclinical models to correlative studies and clinical trials. Specifically, our research areas cover the:

  • Study of the mechanisms of resistance against CDK inhibitors.
  • Characterisation of aberrant signalling axes in triple-negative breast cancer.
  • Role of FGFR1 in cancer progression and therapeutic resistance in hormone-positive cancer.
  • Study of the implications of hypoxia in response to immunotherapy.

Publications

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