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Óscar Fernández-Capetillo and Emilio Lecona Translational
The EMBO Journal. A new mechanism that explains the toxicity of USP7 inhibitors, which are under development for the treatment of cancer, unveiled Understanding the components that control cell division is fundamental to understanding how life...
Mouse adipocytes Basic Research
Nature Metabolism. CNIO researchers discover that a drug already in use in humans corrects obesity in mice, with no side effects It has long been known that obesity is an inflammatory disease, i.e. a chronic defensive reaction of...
TOP2A and DNA Basic Research
Cell Reports. DNA structure itself is involved in genome regulation, scientists find The (when stretched) two-metre-long DNA molecule in each human cell is continuously being unpacked...
TMZ+DAG glioblastoma Translational
Molecular Cancer Therapeutics. Discovered a combination therapy that could improve the survival of patients with aggressive brain tumours Glioblastomas are the most common and most aggressive brain tumours. Their survival rate has barely...
DNA and MutS Basic Research
Nature Structural & Molecular Biology. An international study reveals how the ‘guardian’ of the genome works Scientists from the Genomic Integrity and Structural Biology Group led by Rafael Fernández-Leiro at...
Embryonic stem cells, CNIO Basic Research
Nature Communications. CNIO researchers describe how embryonic stem cells maintain optimal conditions for use in regenerative medicine Scientists at the Proteomics Core Unit of the Spanish National Cancer Research Centre (CNIO), headed...
Sarita Saraswati, Paula Martínez and Maria A. Blasco Basic Research
Nature Aging. CNIO researchers open the door to treatment of renal fibrosis by showing that it is caused by telomere shortening Ageing is a common factor in many diseases. So, what if it were possible to treat them by acting on...
TRF1 and telomeres Basic Research
PLOS Genetics. A CNIO team discovers how telomere involvement in tumour generation is regulated The Telomeres and Telomerase Group led by Maria A. Blasco at the Spanish National Cancer Research...
Image study breast cancer genes Translational
NEJM. The CNIO participates in a study that defines the most important genes that increase the risk of breast cancer Genetic inheritance affects the likelihood of developing breast cancer. Some genes are already known...