Our Friends support allow the CNIO to hire more scientists and open new research lines to understand cancer better, diagnose and treat it effectively… Here are some of them!
"I study the three-dimensional structure of CAD, a protein that is highly expressed in cancer." María analyses how genetic mutations affect the structure of this protein, to develop new therapies for treatment.
"I study the role of telomere dysfunction in the origin of kidney and liver fibrosis, which in its advanced stages may lead to cancer in these organs." Sarita’s goal is to find new therapies for the treatment of these diseases.
"I investigate how RET oncogene activity is altered in certain cancer types, such as lung and breast cancer, as well as neuroblastoma." Rubén aims to find compounds capable of inhibiting this gene that could provide more effective treatments against these types of tumours.
"I investigate the potential of immunology as a strategy against breast cancer, specifically in Triple Negative tumors (TNBC) for a better understanding of its evolution”. Rebeca’s research aims to identify treatments targeted to the tumor with fewer side effects than current therapies.
“I investigate the molecular ‘disguises’ and ‘breaks’ that allow tumor cells to avoid an attack from the immune system.” Understanding the biology of these mechanisms is essential for the development of effective immunotherapies against cancer.
“I study the contribution of STAG2 mutations to aggressive Ewing Sarcoma (EWS), which is the second most frequent type of bone cancer in children.” Maria’s goal is to understand how STAG2 mutations promote the metastatic phenotype to likelly improve the clinical management and the outcome of EWS patients with metastatic disease.
“I study how cells regulate the initiation of DNA replication to ensure the correct inheritance of genetic material”. Sergio aims to understand the mechanisms that prevent improper reduplication of genomic regions leading to genetic instability, a phenomenon that usually fuels different type of cancers.
"I study the role of post-translational modifications of shelterin proteins in telomere maintenance." Giuseppe´s goal is to identify novel pathways and kinases whose activity is required for chromosome end protection.
“I study the structural and molecular bases for the regulation of the mTOR signalling pathway by molecular chaperones.” Sofía’s project explores new potential strategies to target the mTOR pathway against cancer progression.
“I study how melanoma acts ‘at a distance’ before metastasis and evades the immune system in different anatomical structures.” Magdalena’s research has a particular emphasis on the role of MIDKINE in different cell populations of the bone marrow.
"I study how the RET protein works, as it plays an important role in neuroblastoma, a type of fatal childhood cancer (15%) that affects the cells of the adrenal gland and the peripheral nervous system." Moustafa investigates personalised therapeutic strategies in the treatment of this aggressive tumor.
“I explore the novel mechanism between liver cirrhosis and hepatocellular carcinoma.” The aim of Kim’s project is to provide a new treatment option for liver cancer patients.
Previous ‘CNIO Friends’ contracts
"I explore therapeutic and diagnostic options for brain metastasis." These metastases arise in 10-40% of all cancer cases originating from different organs. Neibla is the first author of a study that describes how a compound called silibinin can reduce them.
“We have identified a molecule involved in the survival of tumour cells when they divide. Our working hypothesis is that if we can manage to inhibit the action of those molecules, it should keep the tumour from spreading.” Carolina is looking closely at what could prove to be a new target for pharmacological-based cancer treatments.
“I study neuroblastoma, one of the most frequent tumors in children.” Irene hopes that the molecular findings and the translational aspects of the project, such as the identification of therapeutic strategies and the development of biomarkers, have their application in clinic in the near future.
“I have undertaken a study focusing on gliomas, cerebral tumours common in children and adolescents.” Miguel’s goal is to see that the results are transferred to the clinical sphere, where they can contribute to increasing patients’ survival rates and improving the quality of life.
“I am examining the process by which nanoparticles can be used to transport medication to a specific location in the body, on account of their enhanced ability to reach the compromised cells.” Sebastián’s work involves searching for the best way to make certain that the greatest possible number of nanoparticles actually make it all the way to the tumour location.