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Scientific News

PrimPol binds to damaged DNA Basic Research
The EMBO Journal. A protein that facilitates DNA repair may potentiate chemotherapy Chemotherapy kills tumour cells by causing damage to them. One of the most effective ways of causing...
T7SS secretion system of 'M. tuberculosis' Basic Research
Nature Reviews Microbiology. An international team reviews the latest advances in the understanding of the molecular mechanisms of tuberculosis Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, a bacterium that usually...
Mouse senescent epithelial cells, CNIO Basic Research
Developmental Cell. A connection between senescence and stem cells caused by a breast cancer-initiating protein Early diagnosis and improvement of breast cancer treatments have reduced breast cancer mortality in...
Mouse motor neurons, CNIO Basic Research
The EMBO Journal. CNIO researchers discover the cause of neuronal death in a large proportion of familial ALS patients In Amyotrophic Lateral Sclerosis (ALS), the progressive death of neurons that control body movement...
Óscar Fernández-Capetillo and Emilio Lecona Translational
The EMBO Journal. A new mechanism that explains the toxicity of USP7 inhibitors, which are under development for the treatment of cancer, unveiled Understanding the components that control cell division is fundamental to understanding how life...
Mouse adipocytes Basic Research
Nature Metabolism. CNIO researchers discover that a drug already in use in humans corrects obesity in mice, with no side effects It has long been known that obesity is an inflammatory disease, i.e. a chronic defensive reaction of...
TOP2A and DNA Basic Research
Cell Reports. DNA structure itself is involved in genome regulation, scientists find The (when stretched) two-metre-long DNA molecule in each human cell is continuously being unpacked...
TMZ+DAG glioblastoma Translational
Molecular Cancer Therapeutics. Discovered a combination therapy that could improve the survival of patients with aggressive brain tumours Glioblastomas are the most common and most aggressive brain tumours. Their survival rate has barely...
DNA and MutS Basic Research
Nature Structural & Molecular Biology. An international study reveals how the ‘guardian’ of the genome works Scientists from the Genomic Integrity and Structural Biology Group led by Rafael Fernández-Leiro at...