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Basic Research

CDK4 and RAF1 inactivation Basic Research
PNAS. CNIO researchers develop an effective strategy to induce regression in lung tumours caused by the KRAS oncogene in mice The KRAS oncogene is involved in at least one fifth of all human cancers: KRAS mutations are...
Wild type and STAG2 knock out murine embryos Basic Research
Cell Reports. CNIO and CNIC researchers find clues to clarify why the protein that ‘embraces’ chromosomes has a role in cancer and cardiac development Ana Losada, from the Spanish National Cancer Research Centre (CNIO), is the scientist who identified...
Activation of FAK on lipid membranes Basic Research
The EMBO Journal. The structural basis of Focal Adhesion Kinase activation on lipid membranes unravelled A research team led by Daniel Lietha has just published in The EMBO Journal the mechanistic details...
Basic Research
JCB. CNIO researchers pave the way for a future gene therapy to reverse pulmonary fibrosis associated with ageing Idiopathic pulmonary fibrosis is a potentially lethal disease for which there is currently no cure...
Temozolomide gliomas Basic Research
Nature Communications. A research team of the CNIO and the HKUST identifies how some gliomas develop chemoresistance A team led by Massimo Squatrito, Head of the Seve Ballesteros Foundation Brain Tumour Group at the...
Brain metastasis Basic Research
Cancer Research. The CNIO creates a collaborative platform to streamline brain metastasis research Science is collaborative by nature, since scientific knowledge only advances, step by step, through...
Basic Research
Maria Blasco and Marisol Soengas of the CNIO receive 5 million euros in ‘ERC Advanced Grants’ from the European Union to tackle the immortality of cancer cells and metastasis Two of the major pending questions in the field of oncology are why tumour cells can divide...
mTOR activity in mice liver samples Basic Research
Nature Communications. The CNIO finds that rapamycin has harmful effects when telomeres are short In the past few decades, it was discovered that the rate at which we age is strongly influenced by...
TOP II activity Basic Research
Nature Communications. CNIO and Cabimer researchers show that DNA topological problems may cause lymphoma Researchers from the Spanish National Cancer Research Centre (CNIO), Madrid, and the Andalusian...