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Basic Research

TOP2A and DNA Basic Research
Cell Reports. DNA structure itself is involved in genome regulation, scientists find The (when stretched) two-metre-long DNA molecule in each human cell is continuously being unpacked...
DNA and MutS Basic Research
Nature Structural & Molecular Biology. An international study reveals how the ‘guardian’ of the genome works Scientists from the Genomic Integrity and Structural Biology Group led by Rafael Fernández-Leiro at...
Embryonic stem cells, CNIO Basic Research
Nature Communications. CNIO researchers describe how embryonic stem cells maintain optimal conditions for use in regenerative medicine Scientists at the Proteomics Core Unit of the Spanish National Cancer Research Centre (CNIO), headed...
Sarita Saraswati, Paula Martínez and Maria A. Blasco Basic Research
Nature Aging. CNIO researchers open the door to treatment of renal fibrosis by showing that it is caused by telomere shortening Ageing is a common factor in many diseases. So, what if it were possible to treat them by acting on...
TRF1 and telomeres Basic Research
PLOS Genetics. A CNIO team discovers how telomere involvement in tumour generation is regulated The Telomeres and Telomerase Group led by Maria A. Blasco at the Spanish National Cancer Research...
Long and short telomeres Basic Research
Aging. A CNIO study links severe COVID-19 disease to short telomeres Patients with severe COVID-19 disease have significantly shorter telomeres, according to a study...
gTuRC Basic Research
Science Advances. Scientists from the CNIO and IRB Barcelona assemble the γ-tubulin ring complex in vitro for the first time Researchers from the Microtubule Organization lab, headed by Jens Lüders at IRB Barcelona, and the...
Islet insulin glucagon, CNIO Basic Research
Cell Reports Medicine. A CNIO team describes how a virus can cause diabetes It has recently been described that infection by some enteroviruses – a genus of viruses that...
Marisol Soengas, David Olmeda, Daniela Cerezo, CNIO Basic Research
Nature Medicine. CNIO research team finds how melanoma deceives the immune system, increasing resistance to immunotherapy The sophisticated human immune system has evolved to become an effective protection system against a...