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Basic Research

Basic Research
Molecular Cell. The structure of protein RAF1 revealed: a key step in the development of new drugs against lung cancer One of the main challenges in oncology is the development of drugs against KRAS oncogenes. These...
Basic Research
EMBO Molecular Medicine. A ‘weak spot’ discovered that potentially makes multi-drug resistant tumors vulnerable One of the greatest challenges facing cancer researchers is to understand why some patients don’t...
Basic Research
Journal of Advanced Research. CNIO researchers identify cryptic vulnerabilities in an oncoprotein that could be used in the development of novel anti-cancer drugs RET is a receptor protein with tyrosine kinase activity that can transfer a phosphate group from ATP...
Imagen de un hígado con cirrosis Basic Research
Journal of Hepatology. CNIO researchers identify a mechanism that causes liver cirrhosis Liver cirrhosis is a deadly disease that is still poorly understood, in large part due to the lack...
Basic Research
Nucleic Acids Research. CNIO researchers shed light on the maturation of spliceosome, a cellular process involved in certain types of cancer DNA contains the instructions for life, which need to be read in order to build proteins, which are...
Células humanas con el ADN dañado Basic Research
Cell Reports. Scientists from CNIO and Massachusetts General Hospital develop tools to visualise DNA repair as never before Each one of the trillions of cells that make up the human body suffers more than 10,000 DNA lesions...
SolipPark-Figure-V1 Basic Research
Nature Communications. One mutation or two? Researchers in Spain discover why some genes require one or two hits to promote cancer The language in which the genome’s book of life is written is still being deciphered, which is...
Structure of the LAT2/CD98hc protein Basic Research
PNAS. Spanish scientists determine the mode of action of essential proteins involved in cancer and Alzheimer´s disease The proteins that belong to the HAT family are essential for life as they transport amino acids...
Basic Research
eLife. A master regulator gene for brain cancer with the worst prognosis Researchers at the CNIO and scientists from the School of Medicine of the University of Fribourg,...