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Basic Research

Mice mammary tissue FASN, CNIO Basic Research
Nature Communications. A molecular strategy that helps prevent tumour formation in mice described The body’s process for manufacturing fatty acids is regulated by the enzyme FASN. In normal...
Normal vs hyper-long telomeres, CNIO Basic Research
Nature Communications. CNIO researchers obtain the first mice born with hyper-long telomeres and show that it is possible to extend life without any genetic modification A chance finding ten years ago led to the creation by researchers of the Spanish National Cancer...
3D T7SS, CNIO Basic Research
Nature. CNIO and the University of Würzburg solve the 3D structure of the ‘nanomachine’ that makes tuberculosis virulent An international team consisting of researchers from the Macromolecular Complexes in DNA Damage...
Normal mouse urothelial organoids Basic Research
Nature Communications. A CNIO team uses organoid technology and single-cell RNA sequencing to advance in the study of bladder cancer Investigation of biological mechanisms in urothelial tissue -one of the three types of tissue that...
Un proyecto usará la luz para estudiar y tratar tumores y lesiones cerebrales Basic Research
A project to study and treat injury and tumours in the brain with light The Spanish National Cancer Research Centre (CNIO) and the Spanish National Research Council (CSIC)...
Follicular lymphoma Basic Research
Nature Metabolism. CNIO discovers a connection between nutrients and follicular lymphoma and tests a potential novel therapeutic approach Cancer deploys a vast array of resources to grow: from instability in its genome to inflammation, as...
Model of the role of TRF1 in controlling pluripotency Basic Research
eLife. A ‘butterfly effect’ discovered, through which a single change at telomeres controls the ability of cells to generate a complete organism Pluripotent cells can give rise to all cells of the body, a power that researchers are eager to...
DAB haploids Basic Research
Cell Reports. CNIO researchers find a method to select for mammalian cells with half the number of chromosomes Since the emergence of molecular genetics more than fifty years ago, scientists have tried to...
Maria Blasco and Kurt Whittemore, CNIO Basic Research
PNAS. CNIO researchers discover that the rate of telomere shortening predicts species lifespan A flamingo lives 40 years and a human being lives 90 years; a mouse lives two years and an elephant...