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Basic Research

RUVBL1-RUVBL2 ring Basic Research
Science Advances. CNIO team describes the ‘energy engine’ mechanism of essential protein that mediates a variety of processes in cancer cells Proteins are sometimes described as the building blocks of life; inside cells proteins associate...
CNIO building Basic Research
Cancer Cell. CNIO researchers succeed at removing some types of pancreatic cancer in animal models Researchers from the Experimental Oncology Group, led by Mariano Barbacid at the Spanish National...
FAK activates cell migration Basic Research
PNAS. An international study co-led by CNIO identifies a ‘sensor’ that activates cell migration The cytoskeleton is a structure that not only helps cells maintain their shape and internal...
p62 Basic Research
Cancer Cell. Researchers from the CNIO and the Hospital 12 de Octubre make sense out of the chaos of melanoma Unlike other skin cancers – and without knowing really why – melanoma is one of the most...
Trombocitopenia-2 Basic Research
Journal of Clinical Investigation. CNIO finds the origin of a type of thrombocytopenia caused by an oncogene The Cell Division and Cancer Group of the Spanish National Cancer Research Centre (CNIO) has...
Basic Research
Nucleic Acids Research. An international team led by the CNIO reveals that human genome could contain up to 20% fewer genes A new study led by the Spanish National Cancer Research Centre (CNIO) reveals that up to 20% of...
Gene therapy with telomerase Basic Research
PLoS Genetics. CNIO researchers prove that gene therapy vectors carrying the telomerase gene do not increase the risk of cancer in cancer-prone mouse models Negative results and findings in science are perhaps less newsworthy, but they are no less...
Basic Research
Nature Communications. Discovery of a new tumour suppressor previously thought to be an oncogene A gene that has for decades been considered a tumour promoter, the Plk1 gene, can also perform the...
Basic Research
Nature Structural and Molecular Biology. Deciphering the role of cohesin in genome 3D structure helps understanding tumour cells In recent years it has become evident that the spatial organisation of the genome is key for its...