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Basic Research

Gene therapy with telomerase Basic Research
PLoS Genetics. CNIO researchers prove that gene therapy vectors carrying the telomerase gene do not increase the risk of cancer in cancer-prone mouse models Negative results and findings in science are perhaps less newsworthy, but they are no less...
Basic Research
Nature Communications. Discovery of a new tumour suppressor previously thought to be an oncogene A gene that has for decades been considered a tumour promoter, the Plk1 gene, can also perform the...
Basic Research
Nature Structural and Molecular Biology. Deciphering the role of cohesin in genome 3D structure helps understanding tumour cells In recent years it has become evident that the spatial organisation of the genome is key for its...
Basic Research
Nature Communications. TERRAs, the long non-coding RNAs that protect telomeres, are important epigenetic regulators In 2008, the Telomeres and Telomerase Group led by Maria A. Blasco at the Spanish National Cancer...
Genes and Development. A potential setback in the personalised medicine of cancer One of the most constant and exhaustive searches in cancer research is for a treatment aimed...
CAS9 and GFAP Basic Research
Nature Communications. A novel precision cancer model opens doors to personalised cancer treatment Researchers from the Seve Ballesteros Foundation-CNIO Brain Tumour Group at the Spanish National...
Núria Malats, Latifa Bakiri, Diego Megías, Paco Real, Isidoro Cobo, Irene Millán, Irene Felipe Basic Research
Nature. A gene that increases the risk of pancreatic cancer controls inflammation in normal tissue Inflammation is a defensive response of the body to aggression, but when it persists it can be...
Basic Research
PNAS. CNIO researchers discover a potential new therapeutic strategy for pancreatic cancer In most pancreatic cancer patients, the diagnosis is made when the disease is already advanced, and...
Basic Research
eLife. CNIO researchers cure lung fibrosis in mice with a gene therapy that lengthens telomeres Idiopathic pulmonary fibrosis is a potentially lethal disease associated with the presence of...