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Basic Research

Tumor pulmonar inducido por el KRAS4A. /CNIO Basic Research
PNAS. CNIO researchers clarify the role of the two isoforms of KRAS, the most common oncogene in human cancer KRAS was one of the first oncogenes to be identified, a few decades ago. It is among the most common...
Alejo Efeyan and Ana Ortega, CNIO Basic Research
Cell Reports. CNIO researchers discover a new pathway to tackle follicular lymphoma For their own benefit and to grow beyond control, tumours manipulate cell signals to make it appear...
Estructura TELO2-TTI1-TTI2 complejo mTOR Basic Research
Cell Reports. CNIO researchers help to decipher the structure of the large molecular machine that assembles and activates mTOR The principle that form follows function does not only apply to design and architecture. It also...
De izquierda a derecha: Ana Belén-Plata Gómez, Alejo Efeyan y Nerea Deleyto-Seldas. /CNIO Basic Research
Nature Communications. A molecular switch that allows organisms to adapt to fasting conditions Getting energy and nutrients from the environment – that is, eating – is such an important...
PrimPol binds to damaged DNA Basic Research
The EMBO Journal. A protein that facilitates DNA repair may potentiate chemotherapy Chemotherapy kills tumour cells by causing damage to them. One of the most effective ways of causing...
T7SS secretion system of 'M. tuberculosis' Basic Research
Nature Reviews Microbiology. An international team reviews the latest advances in the understanding of the molecular mechanisms of tuberculosis Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, a bacterium that usually...
Mouse senescent epithelial cells, CNIO Basic Research
Developmental Cell. A connection between senescence and stem cells caused by a breast cancer-initiating protein Early diagnosis and improvement of breast cancer treatments have reduced breast cancer mortality in...
Mouse motor neurons, CNIO Basic Research
The EMBO Journal. CNIO researchers discover the cause of neuronal death in a large proportion of familial ALS patients In Amyotrophic Lateral Sclerosis (ALS), the progressive death of neurons that control body movement...
Mouse adipocytes Basic Research
Nature Metabolism. CNIO researchers discover that a drug already in use in humans corrects obesity in mice, with no side effects It has long been known that obesity is an inflammatory disease, i.e. a chronic defensive reaction of...