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Basic Research

Video MIDKINE Marisol Soengas Basic Research
How melanoma ‘deceives’ the immune system, increasing resistance to immunotherapy A CNIO research team has found how melanoma ‘deceives’ the immune system, increasing...
Spikebody, CNIO Basic Research
The 12 de Octubre Hospital and the CNIO design a new immunotherapy method for fighting different types of coronaviruses A project to generate antibody responses to Covid-19, carried out at the Immunology Unit of 12 de...
CRISPR and fusion genes Basic Research
Nature Communications. CNIO scientists succeed in reprogramming the CRISPR system in mice to eliminate tumour cells without affecting healthy cells The CRISPR/Cas9 gene-editing tool is one of the most promising approaches to advancing treatments of...
E-caderina and R-caderina in breast cancer Basic Research
CP&T. CNIO researchers identify genetic factors associated with the risk to develop hand-foot syndrome during chemotherapy with capecitabine Capecitabine is a chemotherapy drug used for breast and colorectal Cancer cancer. It can extend...
CDK4 and RAF1 inactivation Basic Research
PNAS. CNIO researchers develop an effective strategy to induce regression in lung tumours caused by the KRAS oncogene in mice The KRAS oncogene is involved in at least one fifth of all human cancers: KRAS mutations are...
Wild type and STAG2 knock out murine embryos Basic Research
Cell Reports. CNIO and CNIC researchers find clues to clarify why the protein that ‘embraces’ chromosomes has a role in cancer and cardiac development Ana Losada, from the Spanish National Cancer Research Centre (CNIO), is the scientist who identified...
Activation of FAK on lipid membranes Basic Research
The EMBO Journal. The structural basis of Focal Adhesion Kinase activation on lipid membranes unravelled A research team led by Daniel Lietha has just published in The EMBO Journal the mechanistic details...
Basic Research
JCB. CNIO researchers pave the way for a future gene therapy to reverse pulmonary fibrosis associated with ageing Idiopathic pulmonary fibrosis is a potentially lethal disease for which there is currently no cure...
Temozolomide gliomas Basic Research
Nature Communications. A research team of the CNIO and the HKUST identifies how some gliomas develop chemoresistance A team led by Massimo Squatrito, Head of the Seve Ballesteros Foundation Brain Tumour Group at the...