The Breast Cancer Clinical Research Unit (BCCRU) focuses on the translational interface of therapeutic development. Breast cancer is a heterogeneous disease and, thus, there are large inter-patient variations in terms of disease course, prognosis, relapse, and resistance to conventional or targeted therapeutics. Our activities are directed towards personalised treatment and range from preclinical models to correlative studies and clinical trials.
Our current research areas are to:
Study the implications of hypoxia for immunotherapies.
Understand the individual factors regulating response to immunotherapy in breast cancer, taking advantage of an advanced, personalised “tumouroid” platform.
Tackle mechanisms of resistance against novel therapies in advanced breast cancer.
Incorporate our findings into concept-driven clinical trials.
Develop the new discipline of High-Definition Oncology.
Publications
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Thompson JS ... Macintyre GJ (2025).Predicting resistance to chemotherapy using chromosomal instability signatures. Nat Genet (in press). CNIO Publication.
Hergueta-Redondo M, Sánchez-Redondo S, Hurtado B, Santos V, Pérez-Martínez M, Ximénez-Embún P, McDowell SAC, Mazariegos MS, Mata G, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Graña-Castro O, Megias D, Quail D, Quintela-Fandino M, Peinado H. (2025).The impact of a high fat diet and platelet activation on pre-metastatic niche formation. Nat Commun 16, 2897. CNIO Publication.
Fernándes-Company JF, Quintela-Fandino MA, Sandnes V, García- Rodriguez M (2024).Influence of Music Therapy on the Improvement of Perceived Well-Being Indices in Women with Breast Cancer Undergoing Hormonal Treatment. Am. J. Health Educ. (in press). CNIO Publication.
Martínez-Illescas NG, Leal S, González P, Graña-Castro O, Muñoz-Oliveira JJ, Cortés-Peña A, Gómez-Gil M, Vega Z, Neva V, Romero A, Quintela-Fandino M, Ciruelos E, Sanz C, Aragón S, Sotolongo L, Jiménez S, Caleiras E, Mulero F, Sánchez C, Malumbres M, Salazar-Roa M (2023).miR-203 drives breast cancer cell differentiation. Breast Cancer Res 25, 91. CNIO Publication. Open Access
Morales-Ortega A, Farfán-Sedano AI, Martín-López JVS, Escribá-Bárcena A, Jaenes-Barrios B, Madroñal-Cerezo E, Llarena-Barroso C, Mesa-Plaza N, Frutos-Pérez B, Ruiz-Giardín JM, Duarte-Millán MÁ, Piedrabuena-García SI, Carpintero-García L, Canalejo-Castrillero E, Mora-Hernández B, García-Parra CJ, Magro-García HA, Algaba-García A, Hernández-Muniesa B, Nasarre-López B, Ontañón-Nasarre A, Domínguez-García MJ, Gómez-Santos D, Prieto-Menchero S, García de Tena J, Bermejo F, García-Gil M, Gonzalo-Pascua S, Bernal-Bello D; COVINIB Study Group investigators. (2023).Baricitinib or imatinib in hospitalized COVID-19 patients: results from COVINIB, an exploratory randomized clinical trial. J Med Virol (in press). CNIO Publication.
Calvete O, Mouron S, Barroso A, Soberon N, Blasco MA , Quintela-Fandino M, Benítez J (2020).Long telomeres: A new prognostic factor for severity in triple-negative breast cancer patients. J Transl Sci (in press). CNIO Publication.
Open Access