Scientific News

Fluorescence microscopy visualization of melanoma cells.

Basic Research
18.04.2024 Cancer Communications. Combination of fasting and chemotherapy may improve cancer response, with different effects according to sex In recent years several research groups have found evidence, in animal models, that controlled...

María Martínez Molledo, first author of the study, an Óscar Llorca, senior coauthor. She is a researcher and he is the leader at the CNIO's Macromolecular Complexes in DNA Damage Response Group. Credit: Esther Sánchez / CNIO.

Scientific News
17.04.2024 Nature Communications. Neuronal ‘gateway’ for essential molecules in learning and memory observed at the atomic level Learning from an experience, remembering an anecdote, changing an attitude… all our behaviours...

Acumulación de “proteínas basura”: Células normales (izquierda) y células sometidas al efecto de la proteína tóxica rica en arginina (derecha). En esta se incrementan las proteínas ribosomales (verde fluorescente) y el tamaño de los nucléolos (rojo). Crédito: CNIO.

Scientific News
22.03.2024 Molecular Cell. Accumulation of ‘junk proteins’ identified as one cause of aging and possible source of ALS Amyotrophic lateral sclerosis (ALS) is a degenerative disease. The neurons responsible for movement...

Alejo Efeyan, head of the Metabolism and Cell Signalling Group in his lab at CNIO

Basic Research
18.03.2024 Nature Communications. Discontinuous food intake activates a ‘GPS gene’ in liver cells, thus completing the development of the liver after birth In mammals, the liver detects the body’s energy demand at any given moment and mobilizes...

Real image of DNA molecules being copied in human cells, visualized by immunofluorescence microscopy. The yellow arrows mark where replication begins, and the white arrows indicate the direction in which the molecule is being copied. The distance between the ends of the white arrows is about 100 thousandths of a millimeter (µM); it corresponds to 250,000 'letters' of DNA (bases). / Sara Rodríguez-Acebes. CNIO

Basic Research
04.03.2024 The EMBO Journal. CNIO researchers discover a protein that prevents DNA triplication Every time a cell divides, its DNA is duplicated so that the two daughter cells have the same...

Germinal center with normal structure on the left and aberrant due to lack of NGFR on the right. The maturing B lymphocytes are shown in green and the cells that generate the structure in red /Alberto Hernández. CNIO

Basic Research
26.02.2024 Cell Reports. The molecule behind a potential new therapy for melanoma also plays a key role in autoimmune diseases Three years ago, in 2021, the Microenvironment and Metastasis Group at the Spanish National Cancer...

Translational
14.02.2024 Science Translational Medicine. New immunotherapy for multiple myeloma proves in the lab to be more effective than CAR-T treatment already in use Immunotherapy is already improving treatment options for many cancer types, but research groups keep...

Basic Research
02.02.2024 Science. First atomic-scale ‘movie’ of microtubules under construction, a key process for cell division Cells in the human body are constantly dividing. With each division the genetic information...

Scientific News
25.01.2024 Science Advances. A virus that infected the first animals hundreds of millions of years ago has become essential for the development of the embryo All animals have evolved thanks to the fact that certain viruses infected primitive organisms...