Esta web utiliza cookies para que podamos ofrecerte la mejor experiencia de usuario posible. La información de las cookies se almacena en tu navegador y realiza funciones tales como reconocerte cuando vuelves a nuestra web o ayudar a nuestro equipo a comprender qué secciones de la web encuentras más interesantes y útiles.
Investigadores
- Bárbara Oldrini
Becarios Post-doctorales
- Miguel Jiménez
Becarios Pre-Doctorales
- María del Mar Gardeazabal
- Verónica Matía
Técnicos de Laboratorio
- Alicia Marie Gaëlle Leblond
Glioblastoma (GBM) is the most common and lethal primary central nervous system tumour in adults. Despite the recent advances in treatment modalities, GBM patients generally respond poorly to all therapeutic approaches and prognosis remains dismal. Radiation and chemo-resistance are characteristic of various cancer types, however it is not clear if this therapy resistance is a consequence of tumour progression or if it is intrinsically associated with the genetic events that lead to the tumour formation in the first place. Gaining insights into the pathways that determine this poor treatment response will be instrumental for the development of new therapeutic modalities.
In our laboratory, we use a variety of approaches − both genetic and small molecule drug screenings − coupled with in vivo GBM mouse models in order to identify genes involved in therapy resistance of gliomas. We reason that these studies will help to define new therapeutic targets for treatment of brain tumours.
Publicaciones
- (2020). Correction: Glioblastoma and glioblastoma stem cells are dependent on functional MTH1.. Oncotarget 11, 827. Publicación CNIO.
- (2020). MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas. Nat Commun 11, 3833. Publicación CNIO.
Open Access
- (2020). The Mechanistic GEMMs of Oncogenic Histones. Hum Mol Genet 29, R226-R235. Publicación CNIO.
- (2020). A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways. Nat Commun 11, 2977. Publicación CNIO.
- (2020). Phenotypic mapping of pathological crosstalk between glioblastoma and innate immune cells by synthetic genetic tracing.. Cancer Discovery (in press). Publicación CNIO.
- (2019). LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy. Nat Commun 10, 2416. Publicación CNIO.
Open Access
- (2018). Influenza virus infection causes global RNAPII termination defects. Nat Struct Mol Biol 25, 885-893. Publicación CNIO.
- (2018). Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling. Nat Commun 9, 1466. Publicación CNIO.
Open Access
- (2017). Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.. Cancer Cell 32, 42-56. Publicación CNIO.
- (2017). EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer. Nat Commun 8, 2035. Publicación CNIO.
Open Access
- (2017). GlioVis data portal for visualization and analysis of brain tumor expression datasets.. Neuro-Oncology 19, 139-141. Publicación CNIO.
- (2017). Glioblastoma and glioblastoma stem cells are dependent on functional MTH1. Oncotarget 8, 84671-84684. Publicación CNIO.
- (2017). Inhibition of Trf1 telomere protein impairs tumor initiation and progression in glioblastoma multiform mouse models and patient-derived xenografts.. Cancer Cell 32, 590-607. Publicación CNIO.
- (2016). Targeting MT1-MMP as an ImmunoPET-Based Strategy for Imaging Gliomas. PLoS One 11, e0158634. Publicación CNIO.
Open Access