Grupo de Tumores Cerebrales Fundación Seve-Ballesteros

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“Este contenido se encuentra unicamente en inglés”

Massimo Squatrito
Massimo Squatrito Jefe de Grupo
T +34 917 328 000 (Ext 3850)
msquatrito@cnio.es

Investigadores

  • Bárbara Oldrini

Becarios Post-doctorales

  • Miguel Jiménez

Becarios Pre-Doctorales

  • Carolina Almeida
  • Verónica Matía

Técnicos de Laboratorio

  • Paula Kroon

A decade of studies has underlined the complexity of the genetic events that characterise the genomic landscapes of common forms of human cancer, including gliomas. While a few cancer genes are mutated at high frequencies (>20%), the greatest number of cancer genes in most patients appear at intermediate frequencies (2–20%) or lower. Strikingly, the functional significance of the vast majority of these alterations still remains elusive. A current high priority in glioma research is to functionally validate candidate genetic alterations in order to distinguish those that are significant for cancer progression and treatment response.

In our laboratory, we use a combination of genomic analyses, mouse models and primary tumour cell cultures, with the main goal of identifying the molecular mechanisms that could provide the basis for novel treatments for glioma patients.

Publicaciones

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