Grupo de Inestabilidad Genómica

Inicio | Investigación e innovación | Programas Científicos | Programa de Oncología Molecular | Grupo de Inestabilidad Genómica

Investigadores Científicos

  • Vanesa Lafarga
  • Matilde Murga

Becarios Post-doctorales

  • Ivó Hernández

Becarios Pre-Doctorales

  • Amin El Manchoud
  • Gema López
  • Mario López
  • Jorge Mota
  • Belén Navarro
  • Anabel Sáez

Técnicos de Laboratorio

  • Marta Elena Antón
  • Alicia González
  • Sara Rodrigo

The Genomic Instability Laboratory is interested in understanding the molecular mechanisms causing cancer and other age-related diseases, in order to provide the knowledge needed to develop novel treatments for these diseases. Initially, we focused on the study of replicative stress, a type of DNA damage that fuels genomic instability and is present in many types of cancer. Those studies led to important contributions to basic research and also led to the development of potent and selective ATR inhibitors that were transferred to the pharmaceutical industry for clinical development. Subsequent to elucidating the mechanisms of resistance to ATR inhibition by genetic screens, our Group gradually developed an interest in understanding how cancer cells develop resistance to therapies, and how we can target therapy-resistant cancer cells. In addition, we are actively involved in exploring the contribution of nucleolar stress to cancer and neurodegeneration.

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