Genomic Instability Group

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Staff Scientists

  • Vanesa Lafarga
  • Matilde Murga

Post-Doctoral Fellows

    Graduate Students

    • Gema López
    • Jorge Mota
    • Belén Navarro
    • Anabel Sáez
    • Pablo Valledor

    Technicians

    • Marta Elena Antón
    • Alicia González
    • Sara Rodrigo

    The main goal the Genomic Instability Group is to understand the molecular mechanisms underlying cancer and other age-associated diseases, with the ultimate objective of translating this knowledge into effective treatments for patients. To this end, we have developed over the years several molecular tools and in vivo models, which have led us to make important progress in basic as well as in translational research. Among other achievements, we have extensively studied the molecular mechanisms by which cells duplicate and repair their genomes, developed new inhibitors that can be used for targeted cancer therapy, and created mouse models that revealed the physiological consequences of genomic instability. More recently, we have developed an interest in exploring the mechanisms of drug resistance in cancer therapy and how to overcome this problem in cancer, as well as in other age-related diseases lacking a cure, such as neurodegeneration.

    Publications

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