Grupo de Factores de Crecimiento, Nutrientes y Cáncer

Nabil Djouder Jefe de Grupo
T +34 917328000 (Ext 3830)
ndjouder@cnio.es

Investigadores Científicos

Sladjana Zagorac

Becarios Post-doctorales

Rayan Naser

Becarios Pre-Doctorales

Mariana Angulo
Sergio De la Rosa
Rosa Gallo
Irene Herranz
Carlos Martínez
María del Mar Rigual
Paula Sánchez
Karla Santos

Our laboratory focuses on understanding mechanisms of diseases associated to the digestive system, with a special focus on liver and intestinal diseases. By employing multi- and inter-disciplinary approaches, including the use of mouse models mimicking human disease combined with human data, we aim to: find out what goes wrong in diseased and cancerous tissues; understand how organs can regenerate; potentially engineer new tissues; and, if regeneration goes awry, determine how it contributes to cancer.

Our interest is mainly driven by the discovery of two components initially identified in our laboratory to be downstream targets of the growth factor and nutrient signalling cascades: the URI (Unconventional prefoldin RPB5 Interactor) and MCRS1 (Microspherule protein 1) proteins. URI and MCRS1 expression turned out to be regulated in response to various environmental factors (radiation, nutrients, bacteria, viruses, etc.), compromising their functions and activating pleiotropic circuits to support complex cell signalling networks, provoking severe outcomes. Importantly, URI and MCRS1 are respectively part of 2 independent protein complexes: the URI prefoldin-like and the non-specific lethal (NSL) complexes. While URI might have some co-chaperone activities to maintain proteostasis, we identified MCRS1 to be a new regulator of histone acetylation and, therefore, a central component of the chromatin modifier complex NSL, whose loss in hepatocytes leads to cirrhosis development.

Publicaciones

Martínez-Garay C, Djouder N. (2023). Dietary interventions and precision nutrition in cancer therapy.. Trends Mol Med (in press). Publicación CNIO.
Grazioso TP, Djouder N. (2023). A mechanistic view of the use of cold temperature in the treatment of cancer. iScience 26, 106511. Publicación CNIO.
Garrido A, Kim E, Teijeiro A, Sánchez PS, Gallo R, Nair A, Matamala Montoya M, Perna C, Vicent GP, Muñoz J, Campos-Olivas R, Melms JC, Izar B, Schwabe RF, Djouder N. (2022). Histone acetylation of bile acid transporter genes plays a critical role in cirrhosis. J Hepatol 76, 850-861. Publicación CNIO.
Chaves-Pérez A, Santos-de-Frutos K, de la Rosa S, Herranz-Montoya I, Perna C, Djouder N. (2022). Transit-amplifying cells control R-spondins in the mouse crypt to modulate intestinal stem cell proliferation. J Exp Med 219, e20212405. Publicación CNIO.
Rigual MDM, Sánchez Sánchez P, Djouder N (2022). Is liver regeneration key in hepatocellular carcinoma development?. Trends in Cancer (in press). Publicación CNIO.
Pfister D, Núñez NG, Pinyol R, Govaere O, Pinter M, Szydlowska M, Gupta R, Qiu M, Deczkowska A, Weiner A, Müller F, Sinha A, Friebel E, Engleitner T, Lenggenhager D, Moncsek A, Heide D, Stirm K, Kosla J, Kotsiliti E, Leone V, Dudek M, Yousuf S, Inverso D, Singh I, Teijeiro A, Castet F, Montironi C, Haber PK, Tiniakos D, Bedossa P, Cockell S, Younes R, Vacca M, Marra F, Schattenberg JM, Allison M, Bugianesi E, Ratziu V, Pressiani T, D'Alessio A, Personeni N, Rimassa L, Daly AK, Scheiner B, Pomej K, Kirstein MM, Vogel A, Peck-Radosavljevic M, Hucke F, Finkelmeier F, Waidmann O, Trojan J, Schulze K, Wege H, Koch S, Weinmann A, Bueter M, Rössler F, Siebenhüner A, De Dosso S, Mallm JP, Umansky V, Jugold M, Luedde T, Schietinger A, Schirmacher P, Emu B, Augustin HG, Billeter A, Müller-Stich B, Kikuchi H, Duda DG, Kütting F, Waldschmidt DT, Ebert MP, Rahbari N, Mei HE, Schulz AR, Ringelhan M, Malek N, Spahn S, Bitzer M, Ruiz de Galarreta M, Lujambio A, Dufour JF, Marron TU, Kaseb A, Kudo M, Huang YH, Djouder N, Wolter K, Zender L, Marche PN, Decaens T, Pinato DJ, Rad R, Mertens JC, Weber A, Unger K, Meissner F, Roth S, Jilkova ZM, Claassen M, Anstee QM, Amit I, Knolle P, Becher B, Llovet JM, Heikenwalder M (2021). NASH limits anti-tumour surveillance in immunotherapy-treated HCC. Nature 592, 450-456. Publicación CNIO.
Sánchez PS, Rigual MDM, Djouder N. (2021). Inflammatory and Non-Inflammatory Mechanisms Controlling Cirrhosis Development. Cancers 13, 5045. Publicación CNIO.
Herranz-Montoya I, Park S, Djouder N (2021). A comprehensive analysis of prefoldins and their implication in cancer.. iScience 24, 103273. Publicación CNIO.
Santos-de-Frutos K, Djouder N. (2021). When dormancy fuels tumour relapse.. Commun Biol 4, 747. Publicación CNIO.
Teijeiro A, Garrido A, Ferre A, Perna C, Djouder N (2021). Inhibition of the IL-17A axis in adipocytes suppresses diet-induced obesity and metabolic disorders in mice. Nat Metabolism 3, 496-512. Publicación CNIO.
Torres-Ruiz R, Grazioso TP, Brandt M, Martinez-Lage M, Rodriguez-Perales S, Djouder N. (2021). Detection of chromosome instability by interphase FISH in mouse and human tissues. Star Protocols 2, 100631. Publicación CNIO.
McGinley AM, Sutton CE, Edwards SC, Leane CM, DeCourcey J, Teijeiro A, Hamilton JA, Boon L, Djouder N, Mills KHG (2020). Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1ß-Producing Myeloid Cells that Promote Pathogenic T Cells. Immunity 52, 342-356. Publicación CNIO.
Bernard H, Teijeiro A, Chaves-Pérez A, Perna C, Satish B, Novials A, Wang JP, Djouder N (2020). Coxsackievirus B Type 4 Infection in ß Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing. Cell Rep Med 1, 100125. Publicación CNIO.
Garrido A, Djouder N (2020). Cirrhosis: A Questioned Risk Factor for Hepatocellular Carcinoma. Trends in Cancer 7, 29-36. Publicación CNIO.
Chaves-Pérez A, Yilmaz M, Perna C, de la Rosa S, Djouder N (2019). URI is required to maintain intestinal architecture during ionizing radiation.. Science 364, pii: eaaq1165. Publicación CNIO.
Malehmir M, Pfister D, Gallage S, Szydlowska M, Inverso D, Kotsiliti E, Leone V, Peiseler M, Surewaard BGJ, Rath D, Ali A, Wolf MJ, Drescher H, Healy ME, Dauch D, Kroy D, Krenkel O, Kohlhepp M, Engleitner T, Olkus A, Sijmonsma T, Volz J, Deppermann C, Stegner D, Helbling P, Nombela-Arrieta C, Rafiei A, Hinterleitner M, Rall M, Baku F, Borst O, Wilson CL, Leslie J, O'Connor T, Weston CJ, Adams DH, Sheriff L, Teijeiro A, Prinz M, Bogeska R, Anstee N, Bongers MN, Notohamiprodjo M, Geisler T, Withers DJ, Ware J, Mann DA, Augustin HG, Vegiopoulos A, Milsom MD, Rose AJ, Lalor PF, Llovet JM, Pinyol R, Tacke F, Rad R, Matter M, Djouder N, Kubes P, Knolle PA, Unger K, Zender L, Nieswandt B, Gawaz M, Weber A, Heikenwalder M (2019). Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer. Nat Med 25, 641-655. Publicación CNIO.
Grazioso TP, Brandt M, Djouder N (2019). Diet, Microbiota, and Colorectal Cancer. iScience 21, 168-187. Publicación CNIO. Open Access
Brandt M, Grazioso TP, Fawal MA, Tummala KS, Torres-Ruiz R, Rodriguez-Perales S, Perna C , Djouder N (2018). mTORC1 inactivation promotes colitis-induced colorectal cancer. Cell Metab 27, 118-135. Publicación CNIO.
Youssif C, Cubillos-Rojas M, Comalada M, Llonch E, Perna C, Djouder N, Nebreda AR (2018). Myeloid p38a signaling promotes intestinal IGF-1 production and inflammation-associated tumorigenesis. EMBO Mol Med 10, e8403. Publicación CNIO. Open Access