While cancer research has largely focused on the role of mutated genes, our laboratory investigates the crucial influence of environmental factors, such as diet and exercise, on disease development and progression, with a particular emphasis on cancer. Moreover, recognising the intricate interplay between diet, the nervous system, and the immune system, we are exploring their roles in cancer development, aligning with the emerging fields of cancer neuroscience and neuroimmunomodulation.
We concentrate on diseases of the gastrointestinal tract, including intestinal diseases (colitis, colorectal cancer) and liver diseases (NASH, cirrhosis, hepatocellular carcinoma), while also investigating the mechanisms of obesity, a significant risk factor for these disorders. Utilising genetically engineered mouse models and advanced technologies, our research encompasses tissue regeneration, metabolic dysregulation, inflammatory processes, and early embryonic development to understand fundamental disease mechanisms. Ultimately, we aim to guide the development of novel medicines, particularly immunomodulatory therapies, to combat these challenging diseases.
Open Access