Growth Factors, Nutrients and Cancer Group

Nabil Djouder Group Leader
T +34 917328000 (Ext 3830)
ndjouder@cnio.es

Post-Doctoral Fellows

Albert Harguindey
Eunjeong Kim

Graduate Students

María Inmaculada Berbel
Sergio De la Rosa
Rosa Gallo
Irene Herranz
María del Mar Rigual
Paula Sánchez
Karla Santos

Our laboratory focuses on understanding mechanisms of diseases associated to the digestive system, including liver, intestine and pancreas. Our work aims to integrate mouse models mimicking human disease with state-of-the-art genomics, proteomics, bioinformatics, metabolic pathways and gut microbiome analyses, and therapeutic technologies combined with human data, to: find out what goes wrong in diseased and cancerous tissues; understand how organs can regenerate; and, if regeneration goes awry, to determine how it contributes to cancer.

We put a special emphasis on studying the mechanobiology of tissue development in a health and disease context, from the physical and mechanical perspective at the molecular, cellular, and tissue levels, with the eventual goal to understand how an injured liver progresses to a cancerous tissue, in order to find new therapeutic targets. Additionally, the application of mathematical models to quantitatively study and analyse mechanical forces and cellular plasticity is an important focus in collaboration with other research groups. Finally, the use of nanotechnology combined with in vivo disease models generated in our laboratory might provide additional opportunities to complement our work and impact the field of medicine in diagnosis and treatment.

Publications

Santos-de-Frutos K, Djouder N. (2021). When dormancy fuels tumour relapse.. Commun Biol 4, 747. CNIO Publication.
Pfister D, Núñez NG, Pinyol R, Govaere O, Pinter M, Szydlowska M, Gupta R, Qiu M, Deczkowska A, Weiner A, Müller F, Sinha A, Friebel E, Engleitner T, Lenggenhager D, Moncsek A, Heide D, Stirm K, Kosla J, Kotsiliti E, Leone V, Dudek M, Yousuf S, Inverso D, Singh I, Teijeiro A, Castet F, Montironi C, Haber PK, Tiniakos D, Bedossa P, Cockell S, Younes R, Vacca M, Marra F, Schattenberg JM, Allison M, Bugianesi E, Ratziu V, Pressiani T, D'Alessio A, Personeni N, Rimassa L, Daly AK, Scheiner B, Pomej K, Kirstein MM, Vogel A, Peck-Radosavljevic M, Hucke F, Finkelmeier F, Waidmann O, Trojan J, Schulze K, Wege H, Koch S, Weinmann A, Bueter M, Rössler F, Siebenhüner A, De Dosso S, Mallm JP, Umansky V, Jugold M, Luedde T, Schietinger A, Schirmacher P, Emu B, Augustin HG, Billeter A, Müller-Stich B, Kikuchi H, Duda DG, Kütting F, Waldschmidt DT, Ebert MP, Rahbari N, Mei HE, Schulz AR, Ringelhan M, Malek N, Spahn S, Bitzer M, Ruiz de Galarreta M, Lujambio A, Dufour JF, Marron TU, Kaseb A, Kudo M, Huang YH, Djouder N, Wolter K, Zender L, Marche PN, Decaens T, Pinato DJ, Rad R, Mertens JC, Weber A, Unger K, Meissner F, Roth S, Jilkova ZM, Claassen M, Anstee QM, Amit I, Knolle P, Becher B, Llovet JM, Heikenwalder M (2021). NASH limits anti-tumour surveillance in immunotherapy-treated HCC. Nature 592, 450-456. CNIO Publication.
Teijeiro A, Garrido A, Ferre A, Perna C, Djouder N (2021). Inhibition of the IL-17A axis in adipocytes suppresses diet-induced obesity and metabolic disorders in mice. Nat Metabolism 3, 496-512. CNIO Publication.
McGinley AM, Sutton CE, Edwards SC, Leane CM, DeCourcey J, Teijeiro A, Hamilton JA, Boon L, Djouder N, Mills KHG (2020). Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1ß-Producing Myeloid Cells that Promote Pathogenic T Cells. Immunity 52, 342-356. CNIO Publication.
Garrido A, Djouder N (2020). Cirrhosis: A Questioned Risk Factor for Hepatocellular Carcinoma. Trends in Cancer 7, 29-36. CNIO Publication.
Bernard H, Teijeiro A, Chaves-Pérez A, Perna C, Satish B, Novials A, Wang JP, Djouder N (2020). Coxsackievirus B Type 4 Infection in ß Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing. Cell Rep Med 1, 100125. CNIO Publication.
Grazioso TP, Brandt M, Djouder N (2019). Diet, Microbiota, and Colorectal Cancer. iScience 21, 168-187. CNIO Publication. Open Access
Chaves-Pérez A, Yilmaz M, Perna C, de la Rosa S, Djouder N (2019). URI is required to maintain intestinal architecture during ionizing radiation.. Science 364, pii: eaaq1165. CNIO Publication.
Malehmir M, Pfister D, Gallage S, Szydlowska M, Inverso D, Kotsiliti E, Leone V, Peiseler M, Surewaard BGJ, Rath D, Ali A, Wolf MJ, Drescher H, Healy ME, Dauch D, Kroy D, Krenkel O, Kohlhepp M, Engleitner T, Olkus A, Sijmonsma T, Volz J, Deppermann C, Stegner D, Helbling P, Nombela-Arrieta C, Rafiei A, Hinterleitner M, Rall M, Baku F, Borst O, Wilson CL, Leslie J, O'Connor T, Weston CJ, Adams DH, Sheriff L, Teijeiro A, Prinz M, Bogeska R, Anstee N, Bongers MN, Notohamiprodjo M, Geisler T, Withers DJ, Ware J, Mann DA, Augustin HG, Vegiopoulos A, Milsom MD, Rose AJ, Lalor PF, Llovet JM, Pinyol R, Tacke F, Rad R, Matter M, Djouder N, Kubes P, Knolle PA, Unger K, Zender L, Nieswandt B, Gawaz M, Weber A, Heikenwalder M (2019). Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer. Nat Med 25, 641-655. CNIO Publication.
Brandt M, Grazioso TP, Fawal MA, Tummala KS, Torres-Ruiz R, Rodriguez-Perales S, Perna C , Djouder N (2018). mTORC1 inactivation promotes colitis-induced colorectal cancer. Cell Metab 27, 118-135. CNIO Publication.
Youssif C, Cubillos-Rojas M, Comalada M, Llonch E, Perna C, Djouder N, Nebreda AR (2018). Myeloid p38a signaling promotes intestinal IGF-1 production and inflammation-associated tumorigenesis. EMBO Mol Med 10, e8403. CNIO Publication. Open Access
Tummala KS, Brandt M, Teijeiro A, Graña O, Schwabe RF, Perna C, Djouder N (2017). Hepatocellular Carcinomas Originate Predominantly from Hepatocytes and Benign Lesions from Hepatic Progenitor Cells. Cell Reports 19, 584-600. CNIO Publication.
Garrido A, Djouder N (2017). NAD+ deficits in age-related diseases and cancer.. Trends in Cancer 3, 593-610. CNIO Publication.
Teijeiro A, Djouder N (2017). Nicotinamide riboside or IL-17A signaling blockers to prevent liver disorders. Oncoscience 4, 1-2. CNIO Publication.
Burén S, Gomes AL, Teijeiro A, Fawal MA, Yilmaz M, Tummala KS, Perez M, Rodriguez-Justo M, Campos-Olivas R, Megías D, Djouder N (2016). Regulation of OGT by URI in Response to Glucose Confers c-MYC-Dependent Survival Mechanisms.. Cancer Cell 30, 290-307. CNIO Publication.
Gomes AL, Teijeiro A, Burén S, Tummala KS, Yilmaz M, Waisman A, Theurillat JP, Perna C, Djouder N (2016). Metabolic Inflammation-Associated IL-17A Causes Non-alcoholic Steatohepatitis and Hepatocellular Carcinoma.. Cancer Cell 30, 161-175. CNIO Publication.
Djouder N (2016). Adaptive survival mechanism to glucose restrictions.. Oncoscience 3, 302-303. CNIO Publication.
Garrido A, Brandt M, Djouder N (2016). Transport to Rhebpress activity.. SMALL GTPASES 7, 12-15. CNIO Publication.