Nabil Djouder Group Leader
T +34 917328000 (Ext 3830)
ndjouder@cnio.es

Research conducted over the last decade has focused mainly on understanding the functions and the role of newly discovered mutated genes in the development of various diseases, including cancer. Exposure to environmental factors through the regulation and expression of virulent eukaryotic proteins is an often ignored permanent challenge for an organism. Therefore, our laboratory devotes effort towards understanding the molecular mechanisms linking environmental stresses to disease pathogenesis.

Based on the integration of experimental mouse models combined with the use of human data and nanotechnology, we aim to provide a comprehensive study for a rational approach towards the development of novel mechanism-based diagnostics and therapeutics to detect, prevent and treat diseases.

Publications

• Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer(2019)
  Malehmir M, Pfister D, Gallage S, Szydlowska M, Inverso D, Kotsiliti E, Leone V, Peiseler M, Surewaard BGJ, Rath D, Ali A, Wolf MJ, Drescher H, Healy ME, Dauch D, Kroy D, Krenkel O, Kohlhepp M, Engleitner T, Olkus A, Sijmonsma T, Volz J, Deppermann C, Stegner D, Helbling P, Nombela-Arrieta C, Rafiei A, Hinterleitner M, Rall M, Baku F, Borst O, Wilson CL, Leslie J, O'Connor T, Weston CJ, Adams DH, Sheriff L, Teijeiro A, Prinz M, Bogeska R, Anstee N, Bongers MN, Notohamiprodjo M, Geisler T, Withers DJ, Ware J, Mann DA, Augustin HG, Vegiopoulos A, Milsom MD, Rose AJ, Lalor PF, Llovet JM, Pinyol R, Tacke F, Rad R, Matter M, Djouder N, Kubes P, Knolle PA, Unger K, Zender L, Nieswandt B, Gawaz M, Weber A, Heikenwalder M
  Nat Med 25, 641-655.
• mTORC1 inactivation promotes colitis-induced colorectal cancer(2018)
  Brandt M, Grazioso TP, Fawal MA, Tummala KS, Torres-Ruiz R, Rodriguez-Perales S, Perna C , Djouder N
  Cell Metab 27, 118-135.
• Myeloid p38a signaling promotes intestinal IGF-1 production and inflammation-associated tumorigenesis(2018)
  Youssif C, Cubillos-Rojas M, Comalada M, Llonch E, Perna C, Djouder N, Nebreda AR
  EMBO Mol Med 10, e8403-.
• Hepatocellular Carcinomas Originate Predominantly from Hepatocytes and Benign Lesions from Hepatic Progenitor Cells.(2017)
  Tummala KS, Brandt M, Teijeiro A, Graña O, Schwabe RF, Perna C, Djouder N.
  Cell Reports 19, 584-600.
• NAD+ deficits in age-related diseases and cancer.(2017)
  Garrido A, Djouder N
  Trends in Cancer 3, 593-610.
• Nicotinamide riboside or IL-17A signaling blockers to prevent liver disorders.(2017)
  Teijeiro A, Djouder N
  Oncoscience 4, 1-2.
• Regulation of OGT by URI in Response to Glucose Confers c-MYC-Dependent Survival Mechanisms.(2016)
  Burén S, Gomes AL, Teijeiro A, Fawal MA, Yilmaz M, Tummala KS, Perez M, Rodriguez-Justo M, Campos-Olivas R, Megías D, Djouder N
  Cancer Cell 30, 290-307.
• Metabolic Inflammation-Associated IL-17A Causes Non-alcoholic Steatohepatitis and Hepatocellular Carcinoma.(2016)
  Gomes AL, Teijeiro A, Burén S, Tummala KS, Yilmaz M, Waisman A, Theurillat JP, Perna C, Djouder N
  Cancer Cell 30, 161-175.
• Adaptive survival mechanism to glucose restrictions.(2016)
  Djouder N
  Oncoscience 3, 302-303.
• Transport to Rhebpress activity.(2016)
  Garrido A, Brandt M, Djouder N
  SMALL GTPASES 7, 12-15.
• Alternative activation mechanisms of Protein Kinase B trigger distinct downstream signaling responses.(2015)
  Balzano D, Fawal MA, Velazquez JV, Santiveri CM, Yang J, Pastor J, Campos-Olivas R, Djouder N, Lietha D
  J Biol Chem 290, 24975-24985.
• MCRS1 binds and couples Rheb to amino acid-dependent mTORC1 activation.(2015)
  Fawal MA, Brandt M, Djouder N
  Dev Cell 33, 1-81.
• Boosting NAD+ for the Prevention and Treatment of Liver Cancer.(2015)
  Djouder N
  MOLECULAR & CELLULAR ONCOLOGY 2, e1001199-.
• [14C]-Tryptophan Metabolic Tracing in Liver Cancer Cells.(2015)
  Tummala KS, Djouder N
  Bioprotocol (in press).
• Oncogene-induced NAD+ depletion in tumorigenesis.(2015)
  Tummala KS, Djouder N.
  Oncoscience 2, 318-319.
• Inhibition of De Novo NAD+ Synthesis by Oncogenic URI Causes Liver Tumorigenesis through DNA Damage.(2014)
  Tummala KS, Gomes AL, Yilmaz , Graña O, Bakiri L, Ruppen I, Ximénez-Embún P, Sheshappanavar V, Rodriguez-Justo M, Pisano DG, Wagner EF, Djouder N
  Cancer Cell 26, 826-839.
• Analysis of URI Nuclear Interaction with RPB5 and Components of the R2TP/Prefoldin-Like Complex.(2013)
  Mita P, Savas JN, Ha S, Djouder N, Yates JR 3rd, Logan SK
  PLoS ONE 8, e63879-.