Growth Factors, Nutrients and Cancer Group

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Post-Doctoral Fellows

  • Albert Harguindey
  • Eunjeong Kim

Graduate Students

  • María Inmaculada Berbel
  • Sergio De la Rosa
  • Rosa Gallo
  • Irene Herranz
  • María del Mar Rigual
  • Paula Sánchez
  • Karla Santos

Our laboratory focuses on understanding mechanisms of diseases associated to the digestive system, including liver, intestine and pancreas. Our work aims to integrate mouse models mimicking human disease with state-of-the-art genomics, proteomics, bioinformatics, metabolic pathways and gut microbiome analyses, and therapeutic technologies combined with human data, to: find out what goes wrong in diseased and cancerous tissues; understand how organs can regenerate; and, if regeneration goes awry, to determine how it contributes to cancer.

We put a special emphasis on studying the mechanobiology of tissue development in a health and disease context, from the physical and mechanical perspective at the molecular, cellular, and tissue levels, with the eventual goal to understand how an injured liver progresses to a cancerous tissue, in order to find new therapeutic targets. Additionally, the application of mathematical models to quantitatively study and analyse mechanical forces and cellular plasticity is an important focus in collaboration with other research groups. Finally, the use of nanotechnology combined with in vivo disease models generated in our laboratory might provide additional opportunities to complement our work and impact the field of medicine in diagnosis and treatment.

Publications

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