Programa de Oncologia Molecular

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Óscar Fernández-Capetillo
Óscar Fernández-Capetillo Director
T +34 917328000 (Ext 3480)
ofernandez@cnio.es
Paloma Olave
Paloma Olave Secretary
Lucia Amez
Lucia Amez Secretary
Cristina Álvaro
Cristina Álvaro Secretary

We have made a great deal of progress but still have to stay the course. The only way of dealing with the majority of tumors in adults is to stop them from forming, and for that, you need to have a solid understanding of the formation process
Maria A. Blasco

Cells are able to carry out their functions thanks to a highly sophisticated biochemical mechanism in which molecules interact with other molecules, the new ones interact with others and those with still others, so that you have a fabric woven from an intricate network of relationships. When a tumour develops, part of the biochemical machinery of the cells affected is altered. Molecular Biology is the area in which cancer on that scale is the subject of study. Another way of putting it is that Molecular Oncology focuses on the genes implicated in tumour development and the synthesis of proteins that control the actions of those genes. Understanding how they work is an essential component in the search for more targeted drug treatments and new strategies for fighting cancer.

The Molecular Oncology Programme also investigates the nature of the different processes that lead to cancer in order to learn how best to counter them. Tumours can best be understood as supplementary organs, extrinsic to those that make up the organism as a whole. Accordingly, multiple aspects of tumour biology fall under the purview of this programme. Among them are the stem cells involved in the cancerous process, the ways in which tumour cells interact with other cellular types, the relationship between inflammation and cancer, metastasis, or the metabolic character of tumour cells.

The Molecular Oncology Programme is the most extensive basic science programme at the CNIO. It is structured in 9 research groups and 4 junior research groups that focus on aspects such as DNA and chromosome stability (Maria A. Blasco, Óscar Fernández-Capetillo, and Ana Losada); ocogenes and kinases in the cell cycle and mitosis (Mariano Barbacid and Marcos Malumbres); DNA replication (Juan Méndez); metabolism and cancer (Nabil Djouder and Alejo Efeyan); the molecular mechanisms involved in metastasis (Manuel Valiente and Héctor Peinado); as well as new therapeutic strategies targeting epithelial tumours of the bladder and pancreas (Franciso X. Real), melanoma (María S. Soengas), and cerebral tumours (Massimo Squatrito).

Among their more recent accomplishments is the discovery of new therapies to treat cerebral metastasis and pancreatic cancer.

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