We have a general interest in understanding how DNA topoisomerase activity is regulated to integrate different aspects of genome dynamics, how an imbalance in these processes can lead to the appearance of pathological DNA breaks, and how cells specifically respond to these lesions to maintain genome stability. In this sense, topoisomerase-induced DNA breaks are emerging as important drivers of oncogenic transformation. Moreover, since drugs that target topoisomerase activity are widely used chemotherapeutic agents, our discoveries have direct implications in cancer treatment.
Recently, we opened a new research line aimed at developing novel methods for sequence-specific nucleic-acid detection based on CRISPR-Cas technology, with the idea of producing sensitive and versatile genetic diagnostic kits and devices that can be implemented in a point-of-care setting.
Publications
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López de Alba E, Salguero I, Giménez-Llorente D, Fernández-Sanromán Á, Casajús-Pelegay E, Terrón-Bautista J, Barroso-González J, Bernal JA, Macintyre G, Fernández-Leiro R, Losada A, Cortés-Ledesma F (2024).A comprehensive genetic catalog of human double-strand break repair.. BioRxiv (in press). CNIO Publication. More Info
Olivieri M, Cho T, Álvarez-Quilón A, Li K, Schellenberg MJ, Zimmermann M, Hustedt N, Rossi SE, Adam S, Melo H, Heijink AM, Sastre-Moreno G, Moatti N, Szilard RK, McEwan A, Ling AK, Serrano-Benitez A, Ubhi T, Feng S, Pawling J, Delgado-Sainz I, Ferguson MW, Dennis JW, Brown GW, Cortés-Ledesma F, Williams RS, Martin A, Xu D, Durocher D (2020).A genetic map of the response to DNA damage in human cells. Cell 182, 481-496. CNIO Publication. Open Access
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