We have a broad interest in understanding how DNA topoisomerase activity is regulated to integrate different aspects of genome dynamics, how an imbalance in these processes can lead to the appearance of pathological DNA breaks, and how cells specifically respond to these lesions to maintain genome stability. In this sense, topoisomerase-induced DNA breaks are emerging as important drivers of oncogenic transformation. Moreover, since drugs that target topoisomerase activity are widely used chemotherapeutic agents, our discoveries have direct implications in cancer treatment.
We therefore have a strong focus on the different cellular processes that influence topoisomerase activity, as a potential source of endogenously-occurring and chemotherapeutically-induced DNA breaks, but also on the different mechanisms that participate in the repair of these lesions, and how the outcome of these repair events can compromise genome integrity and fuel oncogenic processes.
Terrón-Bautista J, Bejarano-Franco M, Del Mar Martínez-Sánchez M, López-Hernández L, Díaz-Maldonado H, Santiago-Gómez A, Kidane S, Jaguva Vasudevan AA, García-Domínguez M, Williams RS, Aguilera A, Millán-Zambrano G, Cortés-Ledesma F. (2025).TOP2B modulates DNA supercoiling and chromatin contacts during transcriptional induction. Sci Adv 11, eadu6524. CNIO Publication.
López de Alba E, Salguero I, Giménez-Llorente D, Fernández-Sanromán Á, Casajús-Pelegay E, Terrón-Bautista J, Barroso-González J, Bernal JA, Macintyre G, Fernández-Leiro R, Losada A, Cortés-Ledesma F (2024).A comprehensive genetic catalog of human double-strand break repair.. BioRxiv (in press). CNIO Publication. More Info
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