DNA Replication Group

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Staff Scientists

Post-Doctoral Fellows

  • Estrella Guarino
  • Sergio Muñoz

Graduate Students

  • Elena Blanco
  • Roberto Masdemont
  • Sergi Roig
  • Patricia Ubieto

DNA replication is an essential feature of life but it entails molecular risks ranging from the introduction of mutations to the generation of breaks and chromosomal re-arrangements that promote tumorigenesis. “Replicative stress”, defined as the temporary difficulty of replisome proteins to make a copy of the original DNA, is exacerbated by environmental agents that modify the DNA chemical structure, including UV light, ionising radiation, chemicals in tobacco, and other pollutants. The efficacy of cisplatin, mitomycin C, and other chemotherapy drugs actually relies on the extensive introduction of DNA lesions that cannot be replicated or repaired. In recent years we have focused on the cellular responses to DNA lesions induced by chemotherapy, such as intra-strand and inter-strand crosslinks. In 2021 we continued to investigate the fundamental mechanisms that govern DNA replication in normal and cancer cells, and completed 2 studies about the “re-priming” mechanism activated in response to many DNA lesions.

Publications

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