Grupo de Inmunidad del Cáncer

María Casanova Jefe de Grupo
T +34 917328000 (Ext )
mcasanova@cnio.es

Investigadores Científicos

Alba de Juan

Becarios Post-doctorales

Sarai Martínez

Becarios Pre-Doctorales

Eduardo Garvín
Jan Hochstadt
Mariola Munárriz

Técnicos de Laboratorio

Mónica Gómez

The Cancer Immunity lab studies myeloid cells in the different tumour microenvironments. By focusing on the remarkable heterogeneity of these cells in a tissue-based manner, we aim to uncover their functional roles in shaping T cell responses.

First, we focus on how myeloid training can impact long-term anti-tumour responses. Next, we study how resident macrophages in the lung and in the ovary shape tumour-associated fibroblasts and metabolic responses, respectively. Lastly, we analyse how circadian biology impacts the initiation, progression and unresponsiveness to current therapies in lung cancer.

Publicaciones

Grout JA, Sirven P, Leader AM, Maskey S, Hector E, Puisieux I, Steffan F, Cheng E, Tung N, Maurin M, Vaineau R, Karpf L, Plaud M, Begue AL, Ganesh K, Mesple J, Casanova-Acebes M, Tabachnikova A, Keerthivasan S, Lansky A, Le Berichel J, Walker L, Rahman AH, Gnjatic S, Girard N, Lefevre M, Damotte D, Adam J, Martin JC, Wolf A, Flores RM, Beasley MB, Pradhan R, Muller S, Marron TU, Turley SJ, Merad M, Kenigsberg E, Salmon H (2023). Grout JA, Sirven P, Leader AM, Maskey S, Hector E, Puisieux I, Steffan F, Cheng E, Tung N, Maurin M, Vaineau R, Karpf L, Plaud M, Begue AL, Ganesh K, Mesple J, Casanova-Acebes M, Tabachnikova A, Keerthivasan S, Lansky A, Le Berichel J, Walker L, Rahman AH, Gnjatic S, Girard N, Lefevre M, Damotte D, Adam J, Martin JC, Wolf A, Flores RM, Beasley MB, Pradhan R, Muller S, Marron TU, Turley SJ, Merad M, Kenigsberg E, Salmon H. Cancer Discovery 12, 2606-2625. Publicación CNIO.
Park MD, Reyes-Torres I, LeBerichel J, Hamon P, LaMarche NM, Hegde S, Belabed M, Troncoso L, Grout JA, Magen A, Humblin E, Nair A, Molgora M, Hou J, Newman JH, Farkas AM, Leader AM, Dawson T, D'Souza D, Hamel S, Sanchez-Paulete AR, Maier B, Bhardwaj N, Martin JC, Kamphorst AO, Kenigsberg E, Casanova-Acebes M, Horowitz A, Brown BD, De Andrade LF, Colonna M, Marron TU, Merad M (2023). TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer. Nat Immunol 24, 792-801. Publicación CNIO.
Casanova-Acebes, M., Dalla, E., Leader, A.M, LeBerichel J, Nikolic J, Morales BM , Brown M, Chang C, Troncoso L, Chen ST, Sastre-Perona A, Park M, Tabachnikova A, Dhainaut M, Hamon P, Maier B, Sawai CM, Agulló-Pascual E, Chober M, Brown BD, Reizis B, Marron T, Kenigsberg E, Moussion C, Benaroch, Aguirre-Ghiso JA, Merad M (2021). Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells. Nature 595, 578-584. Publicación en otras instituciones.
Hidalgo A , Casanova-Acebes M (2021). Dimensions of neutrophil life and fate. Semin Immunol (in press). Publicación CNIO.
Casanova-Acebes M, Menéndez-Gutiérrez MP, Porcuna J, Álvarez-Errico D, Lavin Y, García A, Kobayashi S, Le Berichel J, Núñez V, Were F, Jiménez-Carretero D, Sánchez-Cabo F, Merad M, Ricote M (2020). RXRs control serous macrophage neonatal expansion and identity and contribute to ovarian cancer progression.. Nat Commun 11, 1655. Publicación en otras instituciones.
Linde N, Casanova-Acebes M, Sosa MS, Mortha A, Rahman A, Farias E, Harper K, Tardio E, Reyes Torres I, Jones J, Condeelis J, Merad M, Aguirre-Ghiso JA (2018). Macrophages orchestrate breast cancer early dissemination and metastasis.. Nat Commun 9, 21. Publicación en otras instituciones.
Casanova-Acebes M, Nicolás-Ávila JA, Li JL, García-Silva S, Balachander A, Rubio-Ponce A, Weiss LA, Adrover JM, Burrows K, A-González N, Ballesteros I, Devi S, Quintana JA, Crainiciuc G, Leiva M, Gunzer M, Weber C, Nagasawa T, Soehnlein O, Merad M, Mortha A, Ng LG, Peinado H, Hidalgo A (2018). Neutrophils instruct homeostatic and pathological states in naive tissues. J Exp Med 215, 2778-2795. Publicación CNIO.