The Cancer Immunity lab studies myeloid cells in the different tumour microenvironments. By focusing on the remarkable heterogeneity of these cells in a tissue-based manner, we aim to uncover their functional roles in shaping T cell responses.
First, we focus on how myeloid training can impact long-term anti-tumour responses. Next, we study how resident macrophages in the lung and in the ovary shape tumour-associated fibroblasts and metabolic responses, respectively. Lastly, we analyse how circadian biology impacts the initiation, progression and unresponsiveness to current therapies in lung cancer.