Grupo de Microambiente y Metástasis

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Becarios Post-doctorales

  • Marta Hergueta
  • Laura Nogués

Becarios Pre-Doctorales

  • María Elena Castellano
  • Juan García-Agulló
  • María Teresa González
  • Alberto Hernández

Técnicos de Laboratorio

  • Enrique Bastón
  • Sara Sánchez-Redondo
  • Vanesa Santos

Our Group aims to understand the crosstalk between tumour cells and their microenvironment during metastatic progression. Microenvironmental cues are important at all steps of the metastatic process, for which the recruitment of a variety of stromal cells is crucial. Secreted factors play an essential role in this mechanism including soluble factors and extracellular vesicles. These mechanisms of cell-cell communication have become as a novel language of cancer that we aim to decode. We are interested in: 1) understanding how tumour cells crosstalk with stromal cells involved in lymph node and distal metastasis in melanoma, lymphoma, prostate cancer and malignant peripheral nerve sheath tumours; 2) the influence of obesity in melanoma and breast cancer metastasis; and 3) the use of secreted extracellular vesicles (EVs) as surrogate markers of tumour progression. Our studies are focused on deciphering novel biomarkers of metastatic progression and the molecular mechanisms involved, with the aim to define novel therapeutic targets to block metastatic spread.