Our Laboratory focuses on elucidating the crosstalk between tumours and their microenvironment throughout metastatic progression. Currently, we are examining the relationship between extracellular vesicles (EVs) and DNA damage responses (DDR). This project aims to uncover the potential role of EVs in controlling intrinsic/extrinsic DDR and their impact on tumour evolution and metastasis. Additionally, we are investigating the influence of obesity on pre-metastatic niche formation in breast cancer, with a specific emphasis on its adverse outcomes in triple-negative breast cancer patients. This study will help us to understand the relationship between obesity and the progression of breast cancer. Lastly, we are analysing the role of the nerve growth factor receptor (NGFR) in metastasis and therapy resistance in melanoma and head and neck cancer. We are interested in exploring the use NGFR inhibitors in combination with immunotherapy and chemotherapy to enhance therapeutic responses and reduce metastasis.
Publications
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Bastón E, García-Agulló J, Peinado H (2025).The influence of extracellular vesicles on tumor evolution and resistance to therapy. Physiol Rev (in press). CNIO Publication. Open Access
Casanova-Salas I, Aguilar D, Cordoba-Terreros S, Agundez L, Brandariz J, Herranz N, Mas A, Gonzalez M, Morales-Barrera R, Sierra A, Soriano-Navarro M, Cresta P, Mir G, Simonetti S, Rodrigues G, Arce-Gallego S, Delgado-Serrano L, Agustí I, Castellano-Sanz E, Mast R, de Albert M, Celma A, Santamaria A, Gonzalez L, Castro N, Suanes MDM, Hernández-Losa J, Nonell L, Peinado H, Carles J, Mateo J. (2024).Circulating tumor extracellular vesicles to monitor metastatic prostate cancer genomics and transcriptomic evolution. Cancer Cell 42, 1301-1312. CNIO Publication.
Hernández-Barranco A, Santos V, Mazariegos MS, Caleiras E, Nogués L, Mourcin F, Léonard S, Oblet C, Genebrier S, Rossille D, Benguría A, Sanz A, Vázquez E, Dopazo A, Efeyan A, Ortega-Molina A, Cogne M, Tarte K, Peinado H. (2024).NGFR regulates stromal cell activation in germinal centers. Cell Reports 43, 113705. CNIO Publication. Open Access
Couto-Rodriguez A, Villaseñor A, Pablo-Torres C, Obeso D, Rey-Stolle MF, Peinado H, Bueno JL, Reaño-Martos M, Iglesias Cadarso A, Gomez-Casado C, Barbas C, Barber D, Escribese MM, Izquierdo E. (2023).Platelet-Derived Extracellular Vesicles as Lipid Carriers in Severe Allergic Inflammation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24, 12714. CNIO Publication.
Hoshino A, Kim HS, Bojmar L, Gyan KE, Cioffi M, Hernandez J, Zambirinis CP, Rodrigues G, Molina H, Heissel S, Mark MT, Steiner L, Benito-Martin A, Lucotti S, Di Giannatale A, Offer K, Nakajima M, Williams C, Nogués L, Pelissier Vatter FA, Hashimoto A, Davies AE, Freitas D, Kenific CM, Ararso Y, Buehring W, Lauritzen P, Ogitani Y, Sugiura K, Takahashi N, Aleckovic M, Bailey KA, Jolissant JS, Wang H, Harris A, Schaeffer LM, García-Santos G, Posner Z, Balachandran VP, Khakoo Y, Raju GP, Scherz A, Sagi I, Scherz-Shouval R, Yarden Y, Oren M, Malladi M, Petriccione M, De Braganca KC, Donzelli M, Fischer C, Vitolano S, Wright GP, Ganshaw L, Marrano M, Ahmed A, DeStefano J, Danzer E, Roehrl MHA, Lacayo NJ, Vincent TC, Weiser MR, Brady MS, Meyers PA, Wexler LH, Ambati SR, Chou AJ, Slotkin EK, Modak S, Roberts SS, Basu EM, Diolaiti D, Krantz BA, Cardoso F, Simpson AL, Berger M, Rudin CM, Simeone DM, Jain M, Ghajar CM, Batra SK, Stanger BZ, Bui J, Brown KA, Rajasekhar VK, Healey JH, de Sousa M, Kramer K, Sheth S, Baisch J, Pascual V, Heaton TE, La Quaglia MP, Pisapia DJ, Schwartz R, Zhang H, Liu Y, Shukla A, Blavier L, DeClerck YA, LaBarge M, Bissell MJ, Caffrey TC, Grandgenett PM, Hollingsworth MA, Bromberg J, Costa-Silva B, Peinado H, Kang Y, Garcia BA, O'Reilly EM, Kelsen D, Trippett TM, Jones DR, Matei IR, Jarnagin WR, Lyden D (2020).Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. Cell 182, 1044-1061. CNIO Publication. Open Access
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Open Access