Microenvironment and Metastasis Junior Group

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Staff Scientists

Post-Doctoral Fellows

  • Marta Hergueta
  • Laura Nogués

Graduate Students

  • María Elena Castellano
  • María Teresa González
  • Alberto Hernández
  • Lucía Robado

Technicians

  • Sara Sánchez-Redondo
  • Vanesa Santos

Our laboratory aims to understand how the microenvironment impacts metastatic behaviour. Most of the efforts in the past focused on defining intrinsic factors involved in tumour progression and metastasis. However, our interpretation of tumour evolution and metastasis has shifted and currently it is widely accepted that extrinsic factors are actively involved in cancer progression. To tackle this question, our laboratory uses melanoma models to define the role of secreted exosomes in pre-metastatic niche formation and metastasis in the lymph node. In addition, we are exploring the influence of obesity on the metastatic behaviour of melanoma and breast cancer. Finally, we are using novel therapeutic approaches to prevent metastasis in melanoma, lymphoma and malignant peripheral nerve sheath tumour metastasis by targeting both intrinsic and extrinsic factors.

Publications

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