Cancer treatment is no longer only focused on tumour cell analysis. The Microenvironment and Metastasis Group studies the communication between tumour and stromal cells along tumour progression. Cancer treatment requires the analysis of the tumour microenvironment to define specific therapies targeting both the tumour and surrounding cells. Data support that combination of therapies against the tumour and its microenvironment are the future of cancer treatment. In our laboratory, we have focused on understanding the message of a novel ‘language’ between tumour cells and the environment; these are small extracellular vesicles called exosomes. Our data support that tumour-secreted exosomes contain specific signatures of molecules (e.g. proteins, DNA). Exosomes secreted from the tumour can reach metastatic organs and prepare pre-metastatic niche formation, aiding metastatic homing and further metastatic progression.
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Peinado H, Zhang H, Matei IR, Costa-Silva B, Hoshino A, Rodrigues G, Psaila B, Kaplan RN, Bromberg JF, Kang Y, Bissell MJ, Cox TR, Giaccia AJ, Erler JT, Hiratsuka S, Ghajar CM, Lyden D (2017).Pre-metastatic niches: organ-specific homes for metastases.. Nat Rev Cancer 17, 302-317.
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