Microenvironment and Metastasis Junior Group

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Staff Scientists

Post-Doctoral Fellows

  • Marta Hergueta
  • Laura Nogués

Graduate Students

  • Ana Isabel Amor
  • María Elena Castellano
  • María Teresa González
  • Alberto Hernández
  • Lucía Robado

Technicians

  • Marina Mazariegos
  • Sara Sánchez-Redondo

Cancer treatment is no longer only focused on tumour cell analysis. The Microenvironment and Metastasis Group studies the communication between tumour and stromal cells along tumour progression. Cancer treatment requires the analysis of the tumour microenvironment to define specific therapies targeting both the tumour and surrounding cells. Data support that combination of therapies against the tumour and its microenvironment are the future of cancer treatment. In our laboratory, we have focused on understanding the message of a novel ‘language’ between tumour cells and the environment; these are small extracellular vesicles called exosomes. Our data support that tumour-secreted exosomes contain specific signatures of molecules (e.g. proteins, DNA). Exosomes secreted from the tumour can reach metastatic organs and prepare pre-metastatic niche formation, aiding metastatic homing and further metastatic progression.

Publications

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