Grupo de Metabolismo y Señalización Celular

Alejo Efeyan Jefe de Grupo
T +34 917328000 (Ext 3540)
aefeyan@cnio.es

Investigadores Científicos

Bárbara Martínez

Becarios Post-doctorales

Yurena Vivas

Becarios Pre-Doctorales

Lucía de Prado
Elena Fernández
Ana Belén Plata
Elena Sánchez

Técnicos de Laboratorio

María Cuerda
Alba Sanz

In the Metabolism & Cell Signalling Lab we study the links between nutrients, cancer and ageing. All our cells integrate signals emanating from the abundance of intracellular nutrients and from the nutritional state of the entire organism. Integration of these signals is key for adjusting metabolic functions, as well as for energy storage and expenditure, and importantly, the components of these signalling cascades are generally corrupted in cancer and are drivers of the metabolic complications of chronic nutrient overload. Conversely, dietary restriction regimes are extremely efficacious interventions against tumorigenesis and to delay the process of ageing, albeit we still ignore the fundamental molecular underpinnings of such protective effects. We combine mouse genetics and cell biological tools to gain insight into the genetic and environmental corruptions of nutrient signalling cascades, aiming to conceive therapeutic interventions in the context of cancer, obesity, and the process of ageing.

Publicaciones

Smirnov D, Eremenko E, Stein D, Kaluski S, Jasinska W, Cosentino C, Martinez-Pastor B, Brotman Y, Mostoslavsky R, Khrameeva E, Toiber D. (2023). SIRT6 is a key regulator of mitochondrial function in the brain. Cell Death Dis 14, 35. Publicación CNIO.
Deleyto-Seldas N, Efeyan A. (2023). AMPK knocks at the gate of GATOR. Nat Metabolism (in press). Publicación CNIO.
Barradas M, Plaza A, Colmenarejo G, Lázaro I, Costa-Machado LF, Martín-Hernández R, Micó V, López-Aceituno JL, Herranz J, Pantoja C, Tejero H, Diaz-Ruiz A, Al-Shahrour F, Daimiel L, Loria-Kohen V, Ramirez de Molina A, Efeyan A, Serrano M, Pozo OJ, Sala-Vila A, Fernandez-Marcos PJ. (2022). Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity. Nat Commun 13, 5677. Publicación CNIO. Open Access
Di Lorenzo G, Iavarone F, Maddaluno M, Plata-Gómez AB, Aureli S, Quezada Meza CP, Cinque L, Palma A, Reggio A, Cirillo C, Sacco F, Stolz A, Napolitano G, Marin O, Pinna LA, Ruzzene M, Limongelli V, Efeyan A, Grumati P, Settembre C. (2022). Phosphorylation of FAM134C by CK2 controls starvation-induced ER-phagy.. Sci Adv 8, eabo1215. Publicación CNIO. Open Access
Fernández LP, Deleyto-Seldas N, Colmenarejo G, Sanz A, Wagner S, Plata-Gómez AB, Gómez-Patiño M, Molina S, Espinosa-Salinas I, Aguilar-Aguilar E, Ortega S, Graña-Castro O, Loria-Kohen V, Fernández-Marcos PJ, Efeyan A, Ramírez de Molina A. (2022). Folliculin-interacting protein FNIP2 impacts on overweight and obesity through a polymorphism in a conserved 3′ untranslated region. Genome Biol 23, 230. Publicación CNIO.
Ong YT, Andrade J, Armbruster M, Shi C, Castro M, Costa ASH, Sugino T, Eelen G, Zimmermann B, Wilhelm K, Lim J, Watanabe S, Guenther S, Schneider A, Zanconato F, Kaulich M, Pan D, Braun T, Gerhardt H, Efeyan A, Carmeliet P, Piccolo S, Grosso AR, Potente M (2022). A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth.. Nat Metabolism 4, 672-682. Publicación CNIO.
Vivas-García Y, Efeyan A (2022). The metabolic plasticity of B cells.. Front Mol Biosci 9, 991188. Publicación CNIO. Open Access
de la Calle Arregui C, Plata-Gómez AB, Deleyto-Seldas N, García F, Ortega-Molina A, Abril-Garrido J, Rodriguez E, Nemazanyy I, Tribouillard L, de Martino A, Caleiras E, Campos-Olivas R, Mulero F, Laplante M, Muñoz J, Pende M, Sabio G, Sabatini DM, Efeyan A (2021). Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling. Nat Commun 12, 3660. Publicación CNIO. Open Access
Pae J, Ersching J, Castro TBR, Schips M, Mesin L, Allon SJ, Ordovas-Montanes J, Mlynarczyk C, Melnick A, Efeyan A, Shalek AK, Meyer-Hermann M, Victora GD (2021). Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells. J Exp Med 218, e20201699. Publicación CNIO.
Martinez-Pastor B, Silveira GG, Clarke TL, Chung D, Gu Y, Cosentino C, Davidow LS, Mata G, Hassanieh S, Salsman J, Ciccia A, Bae N, Bedford MT, Megías D, Rubin LL, Efeyan A, Dellaire G, Mostoslavsky R (2021). Assessing kinetics and recruitment of DNA repair factors using high content screens. Cell Reports 37, 110176. Publicación CNIO.
Ortega-Molina A, Lebrero-Fernández C, Sanz A, Deleyto-Seldas N, Plata-Gómez AB, Menéndez C, Graña-Castro O, Caleiras E, Efeyan A (2021). Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs.. Cell Reports 36, 109372. Publicación CNIO.
Deleyto-Seldas N, Efeyan A. (2021). The mTOR-Autophagy Axis and the Control of Metabolism. Front Cell Dev Biol 9, 655731. Publicación CNIO.
Spicer G, Gutierrez-Erlandsson S, Matesanz R, Bernard H, Adam AP, Efeyan A, Thompson S (2021). Harnessing DNA for nanothermometry. J BIOPHOTONICS 14, e202000341. Publicación CNIO.
Ortega-Molina A, Efeyan A (2021). From mouse genetics to targeting the Rag GTPase pathway. Molecular Cellular Oncology 8, 1979370. Publicación CNIO.
Plata-Gómez AB, Crespo M, de la Calle Arregui C, de Prado-Rivas L, Sabio G, Efeyan A (2021). Protocol for the assessment of mTOR activity in mouse primary hepatocytes. Star Protocols 2, 100918. Publicación CNIO.
Ramón Y Cajal S, Sancho P, Soucek L, Peinado H, Abad M, Valiente M, Efeyan A, Pardo J, Quesada V, Jimeno J, Duque PM, Antón A, Varela I, Schuhmacher AJ (2020). A spotlight on cancer researchers in Spain: new paradigms and disruptive ideas. Clin Transl Oncol 22, 798-801. Publicación CNIO.
Spicer G, Gutierrez-Erlandsson S, Matesanz R, Bernard H, Adam AP, Efeyan A, Thompson S (2020). Harnessing DNA for nanothermometry. J BIOPHOTONICS (in press). Publicación CNIO.
Spicer G, Efeyan A, Adam AP, Thompson SA (2019). Universal guidelines for the conversion of proteins and dyes into functional nanothermometers.. J BIOPHOTONICS 12, e201900044. Publicación CNIO.
Ramón Y Cajal S, Sancho P, Soucek L, Peinado H, Abad M, Valiente M, Efeyan A, Pardo J, Quesada V, Jimeno J, Duque PM, Antón A, Varela I, Schuhmacher AJ (2019). A spotlight on cancer researchers in Spain: new paradigms and disruptive ideas. Clin Transl Oncol (in press). Publicación CNIO.
Ortega-Molina A, Deleyto-Seldas N, Carreras J, Sanz A, Lebrero-Fernández C, Menéndez C, Vandenberg A, Fernández-Ruiz B, Marín-Arraiza L, de la Calle Arregui C, Plata-Gómez A, Caleiras E , de Martino A , Martínez-Martín N, Troulé K, Piñeiro-Yáñez E, Nakamura N, Araf S, Victora GD, Okosun J, Fitzgibbon J & Efeyan A (2019). Oncogenic Rag GTPase signaling enhances B cell activation and drives folicular lymphoma sensitive to pharmacological inhibition of mTOR.. Nat Metabolism 1, 775-789. Publicación CNIO.