Grupo de Metabolismo y Señalización Celular

Inicio | Investigación e innovación | Programas Científicos | Programa de Oncología Molecular | Grupo de Metabolismo y Señalización Celular

“Este contenido se encuentra unicamente en inglés”

Alejo Efeyan
Alejo Efeyan Jefe de Grupo
T +34 917328000 (Ext 3540)
aefeyan@cnio.es

Investigadores

  • Ana Ortega

Becarios Pre-Doctorales

  • Celia De La Calle
  • Nerea Deleyto
  • Ana Belén Plata

Técnicos de Laboratorio

  • Gabino Hernández
  • Scherezade Jiménez
  • Ana Sagrera
  • Alba Sanz

In the Metabolism and Cell Signalling Lab we study the interplay of nutrients, metabolism and cancer. Every cell in the organism receives signals emanating from the abundance of intracellular nutrients and from the nutritional state of the organism as a whole. Integration of cellular and systemic nutrient abundance cues is key for adequate cellular and organismal functions. Importantly, the components if these signalling cascades are functionally and genetically corrupted in disease states, such as cancer. Together with genetic mutations, environmental perturbations, such as those occurring in obesity, affect the cellular signalling cascades that control responses to nutrients and hormones. In the lab, we combine mouse genetics and cell biological tools to gain insight into the genetic and environmental corruptions of nutrient signalling cascades, aiming to conceive therapeutic interventions in the context of cancer, obesity and the process of ageing.

Publicaciones

  • mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.(2017)
    Zabala-Letona A, Arruabarrena-Aristorena A, Martín-Martín N, Fernandez-Ruiz S, Sutherland JD, Clasquin M, Tomas-Cortazar J, Jimenez J, Torres I, Quang P, Ximenez-Embun P, Bago R, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Torrano V, Cabrera D, van Liempd SM, Cendon Y, Castro E, Murray S, Revandkar A, Alimonti A, Zhang Y, Barnett A, Lein G, Pirman D, Cortazar AR, Arreal L, Prudkin L, Astobiza I, Valcarcel-Jimenez L, Zuñiga-García P, Fernandez-Dominguez I, Piva M, Caro-Maldonado A, Sánchez-Mosquera P, Castillo-Martín M, Serra V, Beraza N, Gentilella A, Thomas G, Azkargorta M, Elortza F, Farràs R, Olmos D, Efeyan A, Anguita J, Muñoz J, Falcón-Pérez JM, Barrio R, Macarulla T, Mato JM, Martinez-Chantar ML, Cordon-Cardo C, Aransay AM, Marks K, Baselga J, Tabernero J, Nuciforo P, Manning BD, Marjon K, Carracedo A
    Nature 547, 109-113.
  • Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma.(2016)
    Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF, Richter J, Bernhart SH, Efeyan A, Iqbal S, Matthews J, Clear A, Guerra-Assunção JA, Bödör C, Quentmeier H, Mansbridge C, Johnson P, Davies A, Strefford JC, Packham G, Barrans S, Jack A, Du MQ, Calaminici M, Lister TA, Auer R, Montoto S, Gribben JG, Siebert R, Chelala C, Zoncu R, Sabatini DM, Fitzgibbon J
    Nat Genet 48, 183-188.
  • Nutrient-sensing mechanisms and pathways.(2015)
    Efeyan A, Comb WC, Sabatini DM.
    Nature 517, 302-310.
  • RagA, but not RagB, is essential for embryonic development and adult life.(2014)
    Efeyan A, Schweitzer LD, Bilate AM, Chang S, Kirak O, Lamming DW, Sabatini DM
    Dev Cell 29, 321-329.
  • Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.(2013)
    Efeyan A, Zoncu R, Chang S, Gumper I, Snitkin H, Wolfson RL, Kirak O, Sabatini DD, Sabatini DM.
    Nature 493, 679-683.
  • Nutrients and growth factors in mTORC1 activation.(2013)
    Efeyan A, Sabatini DM.
    Biochem Soc Trans 41, 902-905.

Subir