- Ana Ortega
- Celia De La Calle
- Nerea Deleyto
- Ana Belén Plata
Técnicos de Laboratorio
- Scherezade Jiménez
- Cristina Lebrero
- Ana Sagrera
- Alba Sanz
In the Metabolism and Cell Signalling Lab we study the interplay of nutrients, metabolism and cancer. Every cell in the organism integrates signals emanating from the abundance of intracellular nutrients and from the nutritional state of the organism as a whole. Integration of cellular and systemic nutrient abundance cues is key for adequate cellular and organismal functions, and importantly, the components of these signalling cascades are generally corrupted in disease states, such as cancer. Together with genetic mutations, environmental perturbations (such as those occurring in obesity) corrupt the cellular signalling cascades that control the responses to nutrients and hormones. In the lab, we combine mouse genetics and cell biological tools to gain insight into the genetic and environmental corruptions of nutrient signalling cascades, aiming to conceive therapeutic interventions in the context of cancer, obesity and the process of ageing.
- (2019). Oncogenic Rag GTPase signaling enhances B cell activation and drives folicular lymphoma sensitive to pharmacological inhibition of mTOR.. Nat Metabolism (in press).
- (2017). mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.. Nature 547, 109-113.
- (2016). Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma.. Nat Genet 48, 183-188.
- (2015). Nutrient-sensing mechanisms and pathways.. Nature 517, 302-310.
- (2014). RagA, but not RagB, is essential for embryonic development and adult life.. Dev Cell 29, 321-329.
- (2013). Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.. Nature 493, 679-683.
- (2013). Nutrients and growth factors in mTORC1 activation.. Biochem Soc Trans 41, 902-905.