- Nuria Gago
- David Olmeda
- Susana Frago
- Xavier Catena
- Marta Contreras
- Cristina Tejedo
Técnicos de Laboratorio
- Tonantzin Guadalupe Calvo
- Estela Cañón
Melanomas are a prime example of how basic and translational research has been translated into improved prognosis for affected patients. Nevertheless, clinical responses are still incomplete. The long-term goals of our Group are to identify new progression biomarkers and therapeutic agents. Focusing on stress response programmes involving apoptosis, autophagy and endosome mobilisation, we have discovered lineage-specific oncogenes that define the melanoma ‘fingerprint’. Transcriptomic and proteomic analyses of the melanoma secretome have enabled us to define how tumour cells remodel the (lymph)angiogenic vasculature and avoid immune recognition. Moreover, we have generated a unique set of animal models for non-invasive imaging of melanoma progression in vivo. These systems have led to the validation of nanoparticle-based treatments that are currently being tested in clinical trials. Our ultimate objective is to improve the management of patients with otherwise refractory metastatic melanomas.
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- (2019). KLF9-dependent ROS regulate melanoma progression in stage-specific manner. Oncogene (in press).
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- (2018). CD38 promotes pristane-induced chronic inflammation and increases susceptibility to experimental lupus by an apoptosis-driven and TRPM2-dependent mechanism. Sci Rep 8, 3357.
- (2017). Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine.. Nature 546, 676-680.
- (2017). Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1.. Nat Commun 8, 2249.
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- (2016). TRANSAUTOPHAGY: European network for multidisciplinary research and translation of autophagy knowledge.. Autophagy 12, 614-617.
- (2016). The nuclear corepressor 1 and the thyroid hormone receptor ß suppress breast tumor lymphangiogenesis.. Oncotarget 7, 78971-78984.
- (2016). The state of melanoma: challenges and opportunities.. Pigment Cell Melanoma Res 29, 404-416.
- (2016). Vesicular trafficking mechanisms in endothelial cells as modulators of the tumor vasculature and targets of antiangiogenic therapies.. FEBS J 283, 25-38.
- (2016). Evaluation of the antiproliferative, proapoptotic, and antiangiogenic effects of a double-stranded RNA mimic complexed with polycations in an experimental mouse model of leiomyoma.. Fertil Steril 105, 529-538.
- (2016). Understanding Tumor-Antigen Presentation in the New Era of Cancer Immunotherapy.. Curr Pharm Design 22, 6234-6250.
- (2015). RAB7 counteracts PI3K-driven macropinocytosis activated at early stages of melanoma development.. Oncotarget 6, 11848-11862.
- (2015). Hyperactivated endolysosomal trafficking in melanoma.. Oncotarget 6, 2583-2584.
- (2015). Let’s make it happen: for gender equality in science!. Pigment Cell Melanoma Res 28, 641-642.
- (2015). Evaluation of the potential therapeutic effects of a double-stranded RNA mimic complexed with polycations in an experimental mouse model of endometriosis.. Fertil Steril 104, 1310-1318.
- (2014). RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway.. Cancer Cell 26, 61-76.
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