Grupo de Carcinogénesis Epitelial

Inicio | Investigación e innovación | Programas Científicos | Programa de Oncología Molecular | Grupo de Carcinogénesis Epitelial

Francisco Real
Francisco Real Jefe de Grupo
T +34 917328000 (Ext 3660)
freal@cnio.es

Investigadores

  • Miriam Marqués

Becarios Post-doctorales

  • Elena del Pilar Andrada
  • Irene Felipe
  • Eleonora Lapi
  • Sumit Paliwal
  • Gabriel Piedrafita

Becarios Pre-Doctorales

  • Sonia Corral
  • Ana Margarita Maldonado
  • Irene Millán
  • Catarina Pereira
  • Mónica Pérez

Técnicos de Laboratorio

  • Miguel Deblas
  • Natalia Del Pozo
  • Jaime Martínez de Villarreal

We focus on the molecular pathophysiology of pancreatic ductal adenocarcinoma (PDAC) and urothelial carcinoma (UC), with a disease-oriented approach. We use patient samples, cultured cells, and genetically modified mice, giving a similar weight to the 3 model systems. Observations made at either of these levels are then extended through additional work. To translate the findings, we bring this knowledge to a ‘population’ level leveraging on information and samples from large patient cohorts.

In PDAC, a main hypothesis is that cell differentiation is a potent tumour suppressor mechanism acting early in carcinogenesis. We use the excellent genetic mouse models available because these processes cannot be readily studied in humans. In mice, PDAC can originate in pancreatic progenitors and in adult acinar and ductal cells. Understanding the contribution of early molecular events is crucial to design better strategies for early tumour detection and prevention in subjects at risk.

In UC, we focus on identifying new genes, using them for improved tumour taxonomy, characterising the mechanisms of action, and applying this knowledge for improved prediction of outcome and therapy.

Publicaciones

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