Grupo de Transformación y Metástasis

Eva González Suárez Jefe de Grupo
T +34 (+34) 917 328 000 (Ext 3550)
egonzalez@cnio.es

Investigadores Científicos

María Jiménez

Becarios Pre-Doctorales

Alexandra Barranco
Alejandro Collado
María Aránzazu Gómez
Jaime Redondo
Alejandro Sánchez

Técnicos de Laboratorio

Víctor López

Tumours exploit and manipulate for their benefit the same mechanisms that regulate homeostasis in healthy tissue. In the Transformation and Metastasis Group, we aim to understand normal mammary gland development and the key events that lead to tumour initiation, progression, and metastasis in order to identify novel therapeutic targets to combat breast cancer. We use complementary tools, including primary cell cultures and organoids, lineage tracing mouse models, and clinical samples with the goal of translating basic knowledge into clinically relevant findings.

Publicaciones

Ciscar M, Trinidad EM, Perez-Chacon G, Alsaleem M, Jimenez M, Jimenez-Santos MJ, Perez-Montoyo H, Sanz-Moreno A, Vethencourt A, Toss M, Petit A, Soler-Monso MT, Lopez V, Gomez-Miragaya J, Gomez-Aleza C, Dobrolecki LE, Lewis MT, Bruna A, Mouron S, Quintela-Fandino M, Al-Shahrour F, Martinez-Aranda A, Sierra A, Green AR, Rakha E, Gonzalez-Suarez E. (2023). RANK is a poor prognosis marker and a therapeutic target in ER-negative postmenopausal breast cancer. EMBO Mol Med 15, e16715. Publicación CNIO.
Cordero A, Santamaría PG, González-Suárez E. (2023). Rank ectopic expression in the presence of Neu and MMTV oncogenes alters mammary epithelial cell populations and their tumorigenic potential. J Mammary Gland Biol 28, 2. Publicación CNIO.
Woo XY, Giordano J, Srivastava A, Zhao ZM, Lloyd MW, de Bruijn R, Suh YS, Patidar R, Chen L, Scherer S, Bailey MH, Yang CH, Cortes-Sanchez E, Xi Y, Wang J, Wickramasinghe J, Kossenkov AV, Rebecca VW, Sun H, Mashl RJ, Davies SR, Jeon R, Frech C, Randjelovic J, Rosains J, Galimi F, Bertotti A, Lafferty A, O'Farrell AC, Modave E, Lambrechts D, Ter Brugge P, Serra V, Marangoni E, El Botty R, Kim H, Kim JI, Yang HK, Lee C, Dean DA 2nd, Davis-Dusenbery B, Evrard YA, Doroshow JH, Welm AL, Welm BE, Lewis MT, Fang B, Roth JA, Meric-Bernstam F, Herlyn M, Davies MA, Ding L, Li S, Govindan R, Isella C, Moscow JA, Trusolino L, Byrne AT, Jonkers J, Bult CJ, Medico E, Chuang JH; PDXNET Consortium; EurOPDX Consortium. (2021). Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts. Nat Genet 53, 86-99. Publicación CNIO.
Benítez S, Cordero A, Santamaría PG, Redondo-Pedraza J, Rocha AS, Collado-Solé A, Jimenez M, Sanz-Moreno A, Yoldi G, Santos JC, De Benedictis I, Gómez-Aleza C, Da Silva-Álvarez S, Troulé K, Gómez-López G, Alcazar N, Palmero I, Collado M, Serrano M, Gonzalez-Suarez E (2021). RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness.. Dev Cell 56, 1727-1741. Publicación CNIO.
Bernat-Peguera A, Navarro-Ventura J, Lorenzo-Sanz L, da Silva-Diz V, Bosio M, Palomero L, Penin RM, Pérez Sidelnikova D, Bermejo JO, Taberna M, Vilariño N, Piulats JM, Mesia R, Viñals JM, González-Suárez E, Capella-Gutierrez S, Villanueva A, Viñals F, Muñoz P. (2021). FGFR Inhibition Overcomes Resistance to EGFR-targeted Therapy in Epithelial-like Cutaneous Carcinoma. Clin Cancer Res 27, 1491-1504. Publicación CNIO.
Gómez-Aleza C, González-Suárez E (2021). Inhibition of RANK signaling as a potential immunotherapy in breast cancer. Oncoimmunology 10, 1923156. Publicación CNIO.
Sanz-Moreno A, Palomeras S, Pedersen K, Morancho B, Pascual T, Galván P, Benítez S, Gomez-Miragaya J, Ciscar M, Jimenez M, Pernas S, Petit A, Soler-Monsó MT, Viñas G, Alsaleem M, Rakha EA, Green AR, Santamaria PG, Mulder C, Lemeer S, Arribas J, Prat A, Puig T, Gonzalez-Suarez E. (2021). RANK signaling increases after anti-HER2 therapy contributing to the emergence of resistance in HER2-positive breast cance. Breast Cancer Res 23, 42. Publicación CNIO.
Gómez-Aleza C, Nguyen B, Yoldi G, Ciscar M, Barranco A, Hernández-Jiménez E, Maetens M, Salgado R, Zafeiroglou M, Pellegrini P, Venet D, Garaud S, Trinidad EM, Benítez S, Vuylsteke P, Polastro L, Wildiers H, Simon P, Lindeman G, Larsimont D, Van den Eynden G, Velghe C, Rothé F, Willard-Gallo K, Michiels S, Muñoz P, Walzer T, Planelles L, Penninger J, Azim HA Jr, Loi S, Piccart M, Sotiriou C, González-Suárez E (2020). Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells.. Nat Commun 11, 6335. Publicación CNIO. Open Access
Gómez-Miragaya J, Díaz-Navarro A, Tonda R, Beltran S, Palomero L, Palafox M, Dobrolecki LE, Huang C, Vasaikar S, Zhang B, Wulf GM, Collado-Sole A, Trinidad EM, Muñoz P, Paré L, Prat A, Bruna A, Caldas C, Arribas J, Soler-Monso MT, Petit A, Balmaña J, Cruz C, Serra V, Pujana MA, Lewis MT, Puente XS, González-Suárez E (2019). Chromosome 12p Amplification in Triple-Negative/BRCA1-Mutated Breast Cancer Associates with Emergence of Docetaxel Resistance and Carboplatin Sensitivity.. Cancer Res 79, 4258-4270. Publicación en otras instituciones.
von Moos R, Costa L, Gonzalez-Suarez E, Terpos E, Niepel D, Body JJ. (2019). Management of bone health in solid tumours: From bisphosphonates to a monoclonal antibody.. Cancer Treat Rev 76, 57-67. Publicación en otras instituciones.
Bernat-Peguera A, Simón-Extremera P, da Silva-Diz V, López de Munain M, Díaz-Gil L, Penin RM, González-Suárez E, Pérez Sidelnikova D, Bermejo O, Viñals JM, Viñals F, Muñoz P. (2019). PDGFR-induced autocrine SDF-1 signaling in cancer cells promotes metastasis in advanced skin carcinoma.. Oncogene 38, 5021-5037. Publicación en otras instituciones.
Piqué L, Martinez de Paz A, Piñeyro D, Martínez-Cardús A, Castro de Moura M, Llinàs-Arias P, Setien F, Gomez-Miragaya J, Gonzalez-Suarez E, Sigurdsson S, Jonasson JG, Villanueva A, Vidal A, Davalos V, Esteller M (2019). Epigenetic inactivation of the splicing RNA-binding protein CELF2 in human breast cancer.. Oncogene 38, 7106-7112. Publicación en otras instituciones.
Gómez-Miragaya J, Morán S, Calleja-Cervantes ME, Collado-Solé A, Paré L, Gómez A, Serra V, Dobrolecki LE, Lewis MT, Diaz-Lagares A, Eroles P, Prat A, Esteller M, González-Suárez E. (2019). The altered transcriptome and DNA methylation profiles of docetaxel resistance in breast cancer PDX models.. Mol Cancer Res 17, 2063-2076. Publicación en otras instituciones.
Cánovas B, Igea A, Sartori AA, Gomis RR, Paull TT, Isoda M, Pérez-Montoyo H, Serra V, González-Suárez E, Stracker TH, Nebreda AR (2018). Targeting p38a Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells.. Cancer Cell 33, 1094-1110. Publicación en otras instituciones.
Koledova Z, Howard BA, Englund J, Bach K, Bentires-Alj M, Gonzalez-Suarez E (2018). European Network of Breast Development and Cancer turned 10 years: a growing family of mammary gland researchers.. Breast Cancer Res 20, 102. Publicación en otras instituciones.
Ruiz de Garibay G, Herranz C, Llorente A, Boni J, Serra-Musach J, Mateo F, Aguilar H, Gómez-Baldó L, Petit A, Vidal A, Climent F, Hernández-Losa J, Cordero Á, González-Suárez E, Sánchez-Mut JV, Esteller M, Llatjós R, Varela M, López JI, García N, Extremera AI, Gumà A, Ortega R, Plà MJ, Fernández A, Pernas S, Falo C, Morilla I, Campos M, Gil M, Román A, Molina-Molina M, Ussetti P, Laporta R, Valenzuela C, Ancochea J, Xaubet A, Casanova Á, Pujana MA. (2018). Correction: Lymphangioleiomyomatosis Biomarkers Linked to Lung Metastatic Potential and Cell Stemness.. PLoS One 13, e0207586. Publicación en otras instituciones.