Mouse Genome Editing Core Unit

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Technicians

  • Beatriz Escobar
  • Carmen Gómez
  • Jaime Muñoz
  • Patricia Prieto
  • Pierfrancesco Vargiu

The term “cancer” encompasses a whole spectrum of extremely complex diseases. Genetic and epigenetic modifications in tumour cells lead to the acquisition of a “malignant” phenotype that enables them to escape normal physiological control. We can accurately reproduce many of these modifications in the mouse, creating animal models to study the disease. Tumour cells also interact, at different levels, with other cells in the body such as those of the tumour stroma, immune, cardiovascular or lymphatic systems, which, in turn, modulate tumour growth, invasion and expansion. The study of such complexity requires in vivo models that reproduce all the features of cancer in a “whole body” context, including the specific genetic alterations that lead to tumour development in each particular tumour. The precise, targeted and controlled modification of the mouse genome, using the most advanced genome editing tools, sustains the generation of genetic mouse models of cancer that are crucial for understanding the molecular basis of tumour development and the preclinical validation of new and more efficient cancer therapies.

Publications

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