Mouse Genome Editing Core Unit

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  • Estefania Ayala
  • Carmen Gómez
  • Jaime Muñoz
  • Patricia Prieto
  • Pierfrancesco Vargiu

Genetically modified mouse models are an essential part of any discipline of biomedical research, including cancer. Our Unit has created about 500 mouse models to support cancer research, using state-of-the-art mouse genetics and gene editing technologies.

The term “cancer” encompasses a whole spectrum of extremely complex diseases in which tumour cells interact, at different levels, with various physiological components, such as the immune system, blood vessels or stromal tissue, which in turn modulate tumour growth, invasion, and expansion. The study of such complexity requires in vivo models that reproduce all the features of cancer in a “whole body” context, including the specific genetic alterations that lead to tumour development in each particular tumour type. The precise, targeted, and controlled modification of the mouse genome, using the most advanced genome editing tools, sustains the generation of genetic mouse models of cancer that are crucial for understanding the molecular basis of tumour development and the preclinical validation of new and more efficient cancer therapies.

The Mouse Genome Editing Unit has more than 20 years of experience in the design, generation, and validation of genetically modified mouse models. In addition, it has created a collection of currently over 1,000 cryopreserved mouse strains from which the entire scientific community may benefit in many different research disciplines.