Genetically engineered mice are essential tools in cancer research because they allow scientists to study the disease in a controlled and biologically relevant context. By introducing or deleting specific genes, researchers can replicate the genetic alterations found in human tumours and observe how cancers initiate, progress, and metastasise over time. These models help uncover the molecular mechanisms that drive tumour development and identify critical pathways involved in cancer progression. Importantly, genetically modified mice are widely used to evaluate the safety and effectiveness of new anticancer therapies before they reach clinical trials, reducing risks for patients. Their physiological similarity to humans, combined with precise genetic control, makes them indispensable for translating basic discoveries into effective cancer treatments. The Unit provides state-of-the-art technology for the genetic modification of the mouse genome and for the cryopreservation of genetically modified strains.
Técnicos de Laboratorio
- Beatriz Escobar
- Carmen Gómez
- Melani Margullón
- Jaime Muñoz
- Patricia Prieto
- María Torres
- Pierfrancesco Vargiu
Publicaciones recientes
- (2025). A Common CTRB misfolding variant associated with pancreatic cancer risk causes ER stress and inflammation in mice. Gut 74, 1452-1466. Publicación CNIO.
- (2025). Vascular HIF2 Signaling Prevents Cardiomegaly, Alveolar Congestion, and Capillary Remodeling During Chronic Hypoxia. Arterioscl Throm Vas 45, e78-e98. Publicación CNIO.
- (2025). T Cell-Specific Inactivation of the PI3K p110α Catalytic Subunit: Effect in T Cell Differentiation and Antigen-Specific Responses. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 26, 595. Publicación CNIO.
- (2024). PP2A-B55 phosphatase counteracts Ki-67-dependent chromosome individualization during mitosis. Cell Reports 43, 114494. Publicación CNIO.
- (2024). Endogenous retroviruses shape pluripotency specification in mouse embryos. Sci Adv 10, eadk9394. Publicación CNIO.
- (2024). miR-203 controls developmental timing and early fate restriction during preimplantation embryogenesis.. BioRxiv (in press). Publicación CNIO.
More Info - (2023). Decoding protein methylation function with thermal stability analysis.. Nat Commun 14, 3016. Publicación CNIO. Open Access
- (2023). Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype. Nat Metabolism 5, 2111-2130. Publicación CNIO. Open Access
- (2022). The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A. Nat Cell Biol 24, 1528-1540. Publicación CNIO. Open Access
- (2022). Folliculin-interacting protein FNIP2 impacts on overweight and obesity through a polymorphism in a conserved 3′ untranslated region. Genome Biol 23, 230. Publicación CNIO. Open Access
- (2021). Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis. J Clin Invest 131, e140695. Publicación CNIO.
- (2021). Live imaging of neolymphangiogenesis identifies acute antimetastatic roles of dsRNA mimics. EMBO Mol Med 13, e12924. Publicación CNIO. Open Access
- (2021). KRAS4A induces metastatic lung adenocarcinomas in vivo in the absence of the KRAS4B isoform. Proc Natl Acad Sci USA 118, e2023112118. Publicación CNIO. Open Access
- (2021). Lymphatic-specific intracellular modulation of receptor tyrosine kinase signaling improves lymphatic growth and function. Sci Signal 14, eabc0836. Publicación CNIO.
- (2021). Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism. Nat Cancer 2, 1387-1405. Publicación CNIO.
- (2021). Deficient adaptation to centrosome duplication defects in neural progenitors causes microcephaly and subcortical heterotopias. JCI Insight 6, 146364. Publicación CNIO.