Cancer encompasses a diversity of complex diseases that arise from genetic and epigenetic alterations in cells, leading to the development of malignant traits that enable these cells to evade normal physiological control. Genetic factors related to the function of different processes in the body such as metabolism, circulation, immunity and ageing, determine, in many cases, susceptibility to cancer development and therapeutic outcome. In addition, lifestyle factors like diet and smoking also affect cancer incidence. To address this intricate complexity, reliable genetically modified animal models offer a holistic «whole-body» context for studying cancer. The laboratory mouse is the best animal model to study the genetic basis of cancer, both because of its similarity to humans and for its versatility for genetic manipulation. Precise and targeted manipulation of the mouse genome, using state-of-the-art genome editing tools, enables the creation of genetic models that are pivotal for understanding the molecular basis of tumourigenesis and for the preclinical evaluation of innovative and more effective cancer therapies.
Técnicos de Laboratorio
- Beatriz Escobar
- Carmen Gómez
- Melani Margullón
- Jaime Muñoz
- Patricia Prieto
- María Torres
- Pierfrancesco Vargiu
Publicaciones recientes
- (2025). A Common CTRB misfolding variant associated with pancreatic cancer risk causes ER stress and inflammation in mice. Gut (in press). Publicación CNIO.
- (2025). Vascular HIF2 Signaling Prevents Cardiomegaly, Alveolar Congestion, and Capillary Remodeling During Chronic Hypoxia. Arterioscl Throm Vas 45, e78-e98. Publicación en otras instituciones.
- (2025). T Cell-Specific Inactivation of the PI3K p110α Catalytic Subunit: Effect in T Cell Differentiation and Antigen-Specific Responses. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 26, 595. Publicación CNIO.
- (2024). PP2A-B55 phosphatase counteracts Ki-67-dependent chromosome individualization during mitosis. Cell Reports 43, 114494. Publicación CNIO.
- (2024). Endogenous retroviruses shape pluripotency specification in mouse embryos. Sci Adv 10, eadk9394. Publicación CNIO.
- (2024). miR-203 controls developmental timing and early fate restriction during preimplantation embryogenesis.. BioRxiv (in press). Publicación CNIO.
More Info - (2023). Decoding protein methylation function with thermal stability analysis.. Nat Commun 14, 3016. Publicación CNIO. Open Access
- (2023). Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype. Nat Metabolism 5, 2111-2130. Publicación CNIO. Open Access
- (2022). The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A. Nat Cell Biol 24, 1528-1540. Publicación CNIO. Open Access
- (2022). Folliculin-interacting protein FNIP2 impacts on overweight and obesity through a polymorphism in a conserved 3′ untranslated region. Genome Biol 23, 230. Publicación CNIO. Open Access
- (2021). Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis. J Clin Invest 131, e140695. Publicación CNIO.
- (2021). Live imaging of neolymphangiogenesis identifies acute antimetastatic roles of dsRNA mimics. EMBO Mol Med 13, e12924. Publicación CNIO. Open Access
- (2021). KRAS4A induces metastatic lung adenocarcinomas in vivo in the absence of the KRAS4B isoform. Proc Natl Acad Sci USA 118, e2023112118. Publicación CNIO. Open Access
- (2021). Lymphatic-specific intracellular modulation of receptor tyrosine kinase signaling improves lymphatic growth and function. Sci Signal 14, eabc0836. Publicación CNIO.
- (2021). Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism. Nat Cancer 2, 1387-1405. Publicación CNIO.
- (2021). Deficient adaptation to centrosome duplication defects in neural progenitors causes microcephaly and subcortical heterotopias. JCI Insight 6, 146364. Publicación CNIO.