Cancer encompasses an extensive range of highly intricate diseases. Alterations in the genetic and epigenetic makeup of tumour cells result in the acquisition of “malignant” characteristics, allowing them to elude normal physiological regulation. Techniques involving genome editing and transgenesis are employed to faithfully replicate these changes in mice, creating indispensable animal models essential for comprehending and improving cancer treatment. Tumour cells engage with various bodily systems, including the immune, cardiovascular, and lymphatic systems, influencing tumour growth, invasion, and expansion. Behavioural elements such as diet or smoking also influence cancer development. To unravel this intricate complexity, dependable in vivo models are imperative, replicating cancer features in a comprehensive “whole body” setting. The precise, targeted, and controlled manipulation of the mouse genome, utilising cutting-edge genome editing tools, facilitates the development of genetic mouse models crucial for deciphering the molecular mechanisms of tumour formation and for preclinically validating advanced and more effective cancer therapies.
Publications
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Sayago C, Sánchez-Wandelmer J, García F, Hurtado B, Lafarga V, Prieto P, Zarzuela E, Ximénez-Embún P, Ortega S, Megías D, Fernández-Capetillo O, Malumbres M, Munoz J. (2023).Decoding protein methylation function with thermal stability analysis.. Nat Commun 14, 3016. CNIO Publication.
Maus M, López-Polo V, Mateo L, Lafarga M, Aguilera M, De Lama E, Meyer K, Sola A, Lopez-Martinez C, López-Alonso I, Guasch-Piqueras M, Hernandez-Gonzalez F, Chaib S, Rovira M, Sanchez M, Faner R, Agusti A, Diéguez-Hurtado R, Ortega S, Manonelles A, Engelhardt S, Monteiro F, Stephan-Otto Attolini C, Prats N, Albaiceta G, Cruzado JM, Serrano M. (2023).Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype. Nat Metabolism 5, 2111-2130. CNIO Publication. Open Access
Lynch CJ, Bernad R, Martínez-Val A, Shahbazi MN, Nóbrega-Pereira S, Calvo I, Blanco-Aparicio C, Tarantino C, Garreta E, Richart-Ginés L, Alcazar N, Graña-Castro O, Gómez-Lopez G, Aksoy I, Muñoz-Martín M, Martinez S, Ortega S, Prieto S, Simboeck E, Camasses A, Stephan-Otto Attolini C, Fernandez AF, Sierra MI, Fraga MF, Pastor J, Fisher D, Montserrat N, Savatier P, Muñoz J, Zernicka-Goetz M, Serrano M (2020).Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases. Nat Cell Biol 22, 1223-1238. CNIO Publication.
Blasco MT, Navas C, Martín-Serrano G, Graña-Castro O, Lechuga CG, Martín-Díaz L, Djurec M, Li Jing, Morales-Cacho L, Esteban-Burgos L, Perales-Patón J, Bousquet-Mur E, Castellano E, Jacob Harrys KC, Cabras L, Mustenau M, Drosten M, Ortega S, Mulero F, Sainz B, Dusetti N, Iovanna J, Sánchez-Bueno F, Hidalgo M, Khiabanian H, Hidalgo M, Rabadán R, Al-Shahrour F, Guerra C, Barbacid M (2019).Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF. Cancer Cell 35, 573-587. CNIO Publication.
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Open Access