Metabolism and Cell Signalling Group

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Research Scientists

  • Bárbara Martínez

Post-Doctoral Fellows

  • Yurena Vivas

Graduate Students

  • Lucía de Prado
  • Lucas Fellmann
  • Elena Fernández
  • Elena Sánchez


  • María Cuerda
  • Jon Lasa
  • Alba Sanz

In the Metabolism & Cell Signalling Lab we study the links between nutrients, cancer and ageing. All our cells integrate signals emanating from the abundance of intracellular nutrients and from the nutritional state of the entire organism. Integration of these signals is key for adjusting metabolic functions, as well as for energy storage and expenditure, and importantly, the components of these signalling cascades are generally corrupted in cancer and are drivers of the metabolic complications of chronic nutrient overload. Conversely, dietary restriction regimes are extremely efficacious interventions against tumorigenesis and to delay the process of ageing, albeit we still ignore the fundamental molecular underpinnings of such protective effects. We combine mouse genetics and cell biological tools to gain insight into the genetic and environmental corruptions of nutrient signalling cascades, aiming to conceive therapeutic interventions in the context of cancer, obesity, and the process of ageing.