In the Metabolism & Cell Signalling Lab we study the links between nutrients, cancer and ageing. All our cells integrate signals emanating from the abundance of intracellular nutrients and from the nutritional state of the entire organism. Integration of these signals is key for adjusting metabolic functions, as well as for energy storage and expenditure. Importantly, the components of these signalling cascades are generally corrupted in cancer and are drivers of the metabolic complications of chronic nutrient overload. Conversely, dietary restriction regimes are extremely efficacious interventions against tumorigenesis and to delay the process of ageing, albeit we still ignore the fundamental molecular underpinnings of such protective effects. We are combining mouse genetics and cell biological tools to gain insight into the genetic and environmental corruptions of nutrient signalling cascades, aiming to conceive therapeutic interventions in the context of cancer, obesity, and the process of ageing.
Publications
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Samson N, Bosoi CR, Roy C, Turcotte L, Tribouillard L, Mouchiroud M, Berthiaume L, Trottier J, Silva HCG, Guerbette T, Plata-Gómez AB, Besse-Patin A, Montoni A, Ilacqua N, Lamothe J, Citron YR, Gélinas Y, Gobeil S, Zoncu R, Caron A, Morissette M, Pellegrini L, Rochette PJ, Estall JL, Efeyan A, Shum M, Audet-Walsh É, Barbier O, Marette A, Laplante M. (2024).HSDL2 links nutritional cues to bile acid and cholesterol homeostasis. Sci Adv 10, eadk9681. CNIO Publication.
Kobialka P, Llena J, Deleyto-Seldas N, Munar-Gelabert M, Dengra JA, Villacampa P, Albinyà-Pedrós A, Muixi L, Andrade J, van Splunder H, Angulo-Urarte A, Potente M, Grego-Bessa J, Castillo SD, Vanhaesebroeck B, Efeyan A, Graupera M. (2023).PI3K-C2β limits mTORC1 signaling and angiogenic growth.. Sci Signal 16, eadg1913. Publication in other institutions.
Barradas M, Plaza A, Colmenarejo G, Lázaro I, Costa-Machado LF, Martín-Hernández R, Micó V, López-Aceituno JL, Herranz J, Pantoja C, Tejero H, Diaz-Ruiz A, Al-Shahrour F, Daimiel L, Loria-Kohen V, Ramirez de Molina A, Efeyan A, Serrano M, Pozo OJ, Sala-Vila A, Fernandez-Marcos PJ. (2022).Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity. Nat Commun 13, 5677. CNIO Publication. Open Access
Di Lorenzo G, Iavarone F, Maddaluno M, Plata-Gómez AB, Aureli S, Quezada Meza CP, Cinque L, Palma A, Reggio A, Cirillo C, Sacco F, Stolz A, Napolitano G, Marin O, Pinna LA, Ruzzene M, Limongelli V, Efeyan A, Grumati P, Settembre C. (2022).Phosphorylation of FAM134C by CK2 controls starvation-induced ER-phagy.. Sci Adv 8, eabo1215. CNIO Publication. Open Access
Spicer G, Gutierrez-Erlandsson S, Matesanz R, Bernard H, Adam AP, Efeyan A, Thompson S (2021).Harnessing DNA for nanothermometry. J BIOPHOTONICS 14, e202000341. CNIO Publication.
Spicer G, Gutierrez-Erlandsson S, Matesanz R, Bernard H, Adam AP, Efeyan A, Thompson S (2020).Harnessing DNA for nanothermometry. J BIOPHOTONICS (in press). CNIO Publication.
Open Access