Metabolism and Cell Signalling Group

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Staff Scientists

  • Bárbara Martínez

Graduate Students

  • Lucía de Prado
  • Nerea Deleyto
  • Ana Belén Plata
  • Elena Sánchez

Technicians

  • Ana Sagrera
  • Alba Sanz

In the Metabolism and Cell Signalling Lab we study the links between nutrients, cancer, and ageing. All cells integrate signals emanating from the abundance of intracellular nutrients and from the nutritional state of the entire organism. Integration of these signals is key for adjusting metabolic functions, energy storage and expenditure; and, importantly, the components of these signalling cascades are generally corrupted in cancer and are drivers of the metabolic complications of chronic nutrient overload. Conversely, dietary restriction regimes are extremely efficacious interventions against tumorigenesis and to delay the process of ageing, albeit we still ignore the fundamental molecular underpinnings of such protective effects. In the lab, we combine mouse genetics and cell biological tools to gain insight into the genetic and environmental corruptions of nutrient signalling cascades, aiming to conceive therapeutic interventions in the context of cancer, obesity and the process of ageing.

Publications

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