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Technicians
- Nines Sanguino Acosta
- Gonzalo Soria
Myeloid cells are the major and most diverse component of solid tumours. In our laboratory, we are interested in identifying novel therapeutic targets to block the pathogenicity of tumour-associated myeloid cells, while preserving their homeostatic functions. In particular, we study the biology of macrophages, neutrophils, and their precursors to understand whether their unique plasticity can be reprogrammed to cure cancer.
Our laboratory tackles these challenges by analysing these cells in the tissue in which they reside, i.e., the tumour microenvironment (TME). As immune cells dynamically adapt and establish heterotypic interaction with other cellular components in the TME, we concentrate our efforts on capturing these interactions. By focusing on breast and lung cancer, and through close collaborations between our laboratory and the clinic, our goal is to discover novel therapeutic venues for cancer patients.
Publications
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- Casanova-Acebes, M., Dalla, E., Leader, A.M, LeBerichel J, Nikolic J, Morales BM , Brown M, Chang C, Troncoso L, Chen ST, Sastre-Perona A, Park M, Tabachnikova A, Dhainaut M, Hamon P, Maier B, Sawai CM, Agulló-Pascual E, Chober M, Brown BD, Reizis B, Marron T, Kenigsberg E, Moussion C, Benaroch, Aguirre-Ghiso JA, Merad M (2021). Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells. Nature 595, 578-584. Publication in other institutions.
- Hidalgo A , Casanova-Acebes M (2021). Dimensions of neutrophil life and fate. Semin Immunol (in press). CNIO Publication.
- Casanova-Acebes M, Menéndez-Gutiérrez MP, Porcuna J, Álvarez-Errico D, Lavin Y, García A, Kobayashi S, Le Berichel J, Núñez V, Were F, Jiménez-Carretero D, Sánchez-Cabo F, Merad M, Ricote M (2020). RXRs control serous macrophage neonatal expansion and identity and contribute to ovarian cancer progression.. Nat Commun 11, 1655. Publication in other institutions.
- Linde N, Casanova-Acebes M, Sosa MS, Mortha A, Rahman A, Farias E, Harper K, Tardio E, Reyes Torres I, Jones J, Condeelis J, Merad M, Aguirre-Ghiso JA (2018). Macrophages orchestrate breast cancer early dissemination and metastasis.. Nat Commun 9, 21. Publication in other institutions.
- Casanova-Acebes M, Nicolás-Ávila JA, Li JL, García-Silva S, Balachander A, Rubio-Ponce A, Weiss LA, Adrover JM, Burrows K, A-González N, Ballesteros I, Devi S, Quintana JA, Crainiciuc G, Leiva M, Gunzer M, Weber C, Nagasawa T, Soehnlein O, Merad M, Mortha A, Ng LG, Peinado H, Hidalgo A (2018). Neutrophils instruct homeostatic and pathological states in naive tissues. J Exp Med 215, 2778-2795. CNIO Publication.
