Experimental Oncology Group

Mariano Barbacid Group Leader
T +34 912246933 (Ext 4000)
mbarbacid@cnio.es

Staff Scientists

Matthias Drosten
Raquel García
Carmen Guerra
Monica Musteanu

Post-Doctoral Fellows

Sara García
Carolina Navas
Guillem Paniagua

Graduate Students

Laura De Esteban
Fernando Fernández
Jing Li
Vasiliki Liaki
Lucía Morales
Marina Salmón
Manuel Sanclemente
Xiaoxu Zhu

Technicians

Irene de Diego
Mª Carmen González
Patricia Teresa Guerra
Silvia Jiménez
Marta San Román
Raquel Villar

KRAS oncogenes have been identified in at least one fifth of all human cancers. In spite of recent successes with checkpoint inhibitors, most KRAS mutant tumours, including lung adenocarcinomas, are still treated with cytotoxic compounds approved over 2 decades ago. Moreover, attempts to block KRAS oncogenic activity with selective inhibitors of the MEK kinase, a downstream effector, have turned out to be major failures. Two MEK inhibitors, Trametinib and Selumetinib, have failed to show significant anti-tumour activity in large phase III clinical trials due to unacceptable toxicities. In our laboratory, we have continued our quest to validate therapeutic targets using a new generation of genetically engineered mouse tumour models that allow us to evaluate their anti-tumour properties as well as their potential toxic effects in tumour- bearing mice. These studies have allowed the identification of c-RAF as a target capable of inducing significant tumour regressions in advanced KRAS/TRP53 mutant lung tumours without inducing major toxicities. These observations suggest that forthcoming c-RAF inhibitors may provide significant therapeutic benefits in the clinic.

Publications

Yao Z, Gao Y, Su W, Yaeger R, Tao J, Na N, Zhang Y, Zhang C, Rymar A, Tao A, Timaul NM, Mcgriskin R, Outmezguine NA, Zhao H, Chang Q, Qeriqi B, Barbacid M, de Stanchina E, Hyman DM, Bollag G, Rosen N (2019). RAF inhibitor PLX8394 selectively disrupts BRAF dimers and RAS-independent BRAF-mutant-driven signaling.. Nat Med 25, 284-291.
Quilichini E, Fabre M, Dirami T, Stedman A, De Vas M, Ozguc O, Pasek RC, Cereghini S, Morillon L, Guerra C, Couvelard A, Gannon M, Haumaitre C (2019). Pancreatic ductal deletion of Hnf1b disrupts exocrine homeostasis, leads to pancreatitis and facilitates tumorigenesis.. Cell Mol Gastroenterol Hepatol (in press). Open Access
Teresa Blasco MT, Navas C, Martín-Serrano G, Graña-Castro O, Lechuga CG, Martín-Díaz L, Djurec M, Li Jing, Morales-Cacho L, Esteban-Burgos L, Perales-Patón J, Bousquet-Mur E, Castellano E, Jacob Harrys KC, Cabras L, Mustenau M, Drosten M, Ortega S, Mulero F, Sainz B, Dusetti N, Iovanna J, Sánchez-Bueno F, Hidalgo M, Khiabanian H, Hidalgo M, Rabadán R, Al-Shahrour F, Guerra C, Barbacid M (2019). Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF. Cancer Cell 35, 573-587.
Cussó L, Musteanu M, Mulero F, Barbacid M, Desco M (2019). Effects of a Ketogenic Diet on [18F]FDG-PET Imaging in a Mouse Model of Lung Cancer. Mol Imaging Biol 21, 279-285.
Moll HP, Mohrherr J, Blaas L, Musteanu M, Stiedl P, Grabner B, Zboray K, König M, Stoiber D, Rülicke T, Strehl S, Eferl R, Casanova E (2019). A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions. Cancers 11, E1226. Open Access
Y. Gao, M. Chang, D. McKay, N. Na, B. Zhou, R. Yaeger, N. Torres, K. Muniz, M. Drosten, M. Barbacid, G. Caponigro, D. Stuart, H. Möbitz, D. Solit, O. Abdel-Wahab, B. Taylor, Z. Yao, and N. Rosen (2018). Allele-specific mechanisms of activation of MEK1 mutants determine their properties. Cancer Discovery 8, 648-651.
H.P. Moll, K. Pranz, M. Musteanu3, B. Grabner2, N. Hruschka2, J. Mohrherr2, P. Aigner, P. Stiedl, L. Brcic, V. Laszlo, D. Schramek, R. Moriggl, R. Eferl, J. Moldvay, K. Dezso, P. P. Lopez-Casas3, D. Stoiber, M. Hidalgo, J. Penninger, M. Sibilia, B. Gy?rffy, M. Barbacid, B. Dome, H. Popper, E. Casanova (2018). Afatinib restrains K-RAS driven lung tumorigenesis. Sci Transl Med 10, 446.
Orozco CA, Martinez-Bosch N, Guerrero PE, Vinaixa J, Iglesias M, Moreno M, Djurec M, Poirier F, Gabius HJ, Fernandez-Zapico M, Hwang RF, Guerra C, Rabinovich G and Navarro P (2018). Targeting galectin-1 inhibits pancreatic cancer progression by interrupting tumor-stroma cross-talk. Proc Natl Acad Sci USA 115, E3769-E3778.
Mayor-Ruiz C, Olbrich T, Drosten M, Lecona E, Vega-Sendino M, Ortega S, Dominguez O, Barbacid M, Ruiz S, Fernandez-Capetillo O (2018). ERF deletion rescues RAS deficiency in mouse embryonic stem cells. Genes Dev 32, 568-576.
Sanclemente M, Francoz S, Esteban-Burgos L, Bousquet-Mur E, Djurec M, Lopez-Casas PP, Hidalgo M, Guerra C, Drosten M, Musteanu M, Barbacid M (2018). c-RAF Ablation Induces Regression of Advanced Kras/Trp53 Mutant Lung Adenocarcinomas by a Mechanism Independent of MAPK Signaling. Cancer Cell 33, 217-228.
Djurec M, Graña O, Lee A, Troulé K, Espinet E, Cabras L, Navas C, Blasco MT, Martín-Díaz L, Burdiel M, Li J, Liu Z, Vallespinós M, Sanchez-Bueno F, Sprick MR, Trumpp A, Sainz B Jr., Al-Shahrour F, Rabadan R, Guerra C, Barbacid M (2018). Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors. Proc Natl Acad Sci USA 115, E1147-E1156.
Sonntag R, Giebeler N, Nevzorova YA, Bangen JM, Fahrenkamp D, Lambertz D, Haas U, Hu W, Gassler N, Cubero FJ, Müller-Newen G, Abdallah AT, Weiskirchen R, Ticconi F, Costa IG, Barbacid M, Trautwein C, Liedtke C (2018). Cyclin E1 and cyclin-dependent kinase 2 are critical for initiation, but not for progression of hepatocellular carcinoma. Proc Natl Acad Sci USA 115, 9282-9287.
Drosten M, Guerra C, Barbacid M (2018). Genetically Engineered Mouse Models of K-Ras-Driven Lung and Pancreatic Tumors: Validation of Therapeutic Targets. Cold Spring Harb Perspect Med 8, a031542.
Cussó L, Musteanu M, Mulero F, Barbacid M, Desco M (2018). Effects of a Ketogenic Diet on [18F]FDG-PET Imaging in a Mouse Model of Lung Cancer. Mol Imaging Biol 21, 279-285.
Simón-Carrasco L, Jiménez G, Barbacid M, Drosten M (2018). The Capicua tumor suppressor: a gatekeeper of Ras signaling in development and cancer. Cell Cycle 17, 702-711.
Nieto P, Ambrogio C, Esteban-Burgos L, Gómez-López G, Blasco MT, Yao Z, Marais R, Rosen N, Chiarle R, Pisano DG, Barbacid M and Santamaría D (2017). A Braf kinase-inactive mutant induces lung adenocarcinoma.. Nature 548, 239-243.
Yao Z, Yaeger R, Tao A, Torres NM, Chang MT, Drosten M, Zhao H, Rodrik-Outmezguine VS, Cecchi F, Hembrough T, Michels J, Baumert H, Miles L, Campbell NM, de Stanchina E, Solit DB, Barbacid M, Taylor BS and Rosen N (2017). Tumors with class 3 BRAF mutants are sensitive to the inhibition of activated RAS.. Nature 548, 234-238.
Papale A, d'Isa R, Menna E, Cerovic M, Solari N, Hardingham N, Cambiaghi M, Cursi M, Barbacid M, Leocani L, Fasano S, Matteoli M, Brambilla R (2017). Severe Intellectual Disability and Enhanced Gamma-Aminobutyric Acidergic Synaptogenesis in a Novel Model of Rare RASopathies.. Biol Psychiat 81, 179-192.
Simón-Carrasco L, Graña O, Salmón M, Jacob HKC, Gutierrez A, Jiménez G, Drosten M, Barbacid M (2017). Inactivation of Capicua in adult mice causes T cell lymphoblastic lymphoma.. Genes Dev 31, 1456-1468.
Drosten M, Simón-Carrasco L, Hernández-Porras I, Lechuga CG, Blasco MT, Jacob HK, Fabbiano S, Potenza N, Bustelo XR, Guerra C, Barbacid M (2017). H-Ras and K-Ras oncoproteins induce different tumor spectra when driven by the same regulatory sequences.. Cancer Res 77, 707-718.
Forés M, Simón-Carrasco L, Ajuria L, Samper N, González-Crespo S, Drosten M, Barbacid M, Jiménez G (2017). A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer. PLoS Genet 13, e1006622.
Ambrogio C, Barbacid M, Santamaría D (2017). In vivo oncogenic conflicto triggered by co-existing KRAS and EGFR activating mutations in lung adenocarcinoma.. Oncogene 36, 2309-2318.
Chirivella L, Kirstein M, Ferrón SR, Domingo-Muelas A, Durupt FC, Acosta-Umanzor C, Cano-Jaimez M, Pérez-Sánchez F, Barbacid M, Ortega S, Burks D, Fariñas I (2017). Cdk4 regulates adult neural stem cell proliferation and differentiation in response to insulin-IRS2 signals.. Stem Cells 35, 2403-2416.
Schreiber J, Grimbergen LA, Overwater I, Vaart TV, Stedehouder J, Schuhmacher AJ, Guerra C, Kushner SA, Jaarsma D, Elgersma Y (2017). Mechanisms underlying cognitive deficits in a mouse model for Costello Syndrome are distinct from other RASopathy mouse models. Sci Rep 7, 1256.
Drosten M, Guerra C and Barbacid M (2017). Genetically engineered mouse models of K-Ras driven lung and pancreatic tumors: Validation of therapeutic targets. In Additional Perspectives on Ras and Cancer in the 21st Century (ed. L. VanAelst, J. Downward and F. McCormick).. Cold Spring Harbor Laboratory Press (in press).
Hernández-Porras I, Guerra C (2017). Modeling Rasopathies with genetically modified mouse models.. Methods Mol Biol 1487, 379-408.
Højgaard L, Löwenberg B, Selby P, Lawler M, Banks I, Law K, Albreht T, Armand JP, Barbacid M, Barzach M, Bergh J, Cameron D, Conte P, de Braud F, de Gramont A, De Lorenzo F, Diehl V, Diler S, Erdem S, Geissler J, Gore-Booth J, Henning G, Horgan D, Jassem J, Johnson P, Kaasa S, Kapitein P, Karjalainen S, Kelly J, Kienesberger A, La Vecchia C, Lacombe D, Lindahl T, Luzzatto L, Malby R, Mastris K, Meunier F, Murphy M, Naredi P, Nurse P, Oliver K, Pearce J, Pelouchov J, Piccart M, Pinedo B, Spurrier-Bernard G, Sullivan R, Tabernero J, Van de Velde C, van Herk B, Vedsted P, Waldmann A, Weller D, Wilking N, Wilson R, Yared W, Zielinski C, Zur Hausen H, Le Chevalier T, Johnston P. (2017). The European Cancer Patient’s Bill of Rights, update and implementation 2016.. ESMO OPEN 1, e000127.
Lechuga CG, Simón-Carrasco L, Jacob HKC, Drosten M (2017). Genetic validation of cell proliferation via Ras-independent activation of the Raf/Mek/Erk pathway.. Methods Mol Biol 1487, 269-276.
Schuhmacher AJ, Hernández-Porras I, García-Medina R, Guerra C (2017). Lessons learnt from genetic studies in mice into Noonan syndrome.. Expert Review of Endocrinology and Metabolism 12, 367-378.
Ambrogio C, Gómez-López G, Falcone M, Vidal A, Nadal E, Crosetto N, Blasco RB, Fernández-Marcos PJ, Sánchez-Céspedes M, Ren X, Wang Z, Ding K, Hidalgo M, Serrano M, Villanueva A, Santamaría D, Barbacid M (2016). Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma.. Nat Med 22, 270-277.
Martinelli P, Madriles F, Cañamero M, Pau EC, Pozo ND, Guerra C, Real FX. (2016). The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice.. Gut 65, 476-486.
Hernández-Porras I, Schuhmacher AJ, Garcia-Medina R, Jiménez B, Cañamero M, de Martino A, Guerra C (2016). K-Ras(V14I) -induced Noonan syndrome predisposes to tumour development in mice.. J Pathol 239, 206-217.
Ambrogio C, Barbacid M, Santamaría D (2016). In vivo oncogenic conflict triggered by co-existing KRAS and EGFR activating mutations in lung adenocarcinoma.. Oncogene (in press).
Augereau C, Collet L, Vargiu P, Guerra C, Ortega S, Lemaigre FP, Jacquemin P (2016). Chronic pancreatitis and lipomatosis are associated with defective function of ciliary genes in pancreatic ductal cells.. Hum Mol Genet 25, 5017-5026.
Drosten M, Barbacid M (2016). Modeling K-Ras-driven lung adenocarcinoma in mice: preclinical validation of therapeutic targets.. J Mol Med-Jmm 94, 121-135.
Lopez S, Voisset E, Tisserand JC, Mosca C, Prebet T, Santamaria D, Dubreuil P, De Sepulveda P (2016). An essential pathway links FLT3-ITD, HCK and CDK6 in acute myeloid leukemia.. Oncotarget 7, 51163-51173.
Ambrogio C, Nadal E, Villanueva A, Gómez-López G, Cash TP, Barbacid M, Santamaría D (2016). KRAS-driven lung adenocarcinoma: combined DDR1/Notch inhibition as an effective therapy.. ESMO OPEN 1, e000076.
García-Beccaria M, Martínez P, Méndez-Pertuz M, Martínez S, Blanco-Aparicio C, Cañamero M, Mulero F, Ambrogio C, Flores JM, Megias D, Barbacid M, Pastor J, Blasco MA (2015). Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage.. EMBO Mol Med 7, 930-949.
Lopez-Contreras AJ, Specks J, Barlow JH, Ambrogio C, Desler C, Vikingsson S, Rodrigo-Perez S, Green H, Rasmussen LJ, Murga M, Nussenzweig A, Fernandez-Capetillo O (2015). Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice.. Genes Dev 29, 690-695.
Trakala M, Rodríguez-Acebes S, Maroto M, Symonds CE, Santamaría D, Ortega S, Barbacid M, Méndez J, Malumbres M. (2015). Functional reprogramming of polyploidization in megakaryocytes.. Dev Cell 32, 155-167.
Hidalgo M, Plaza C, Musteanu M, Illei P, Brachmann CB, Heise C, Pierce DW, Lopez-Casas PP, Menendez C, Tabernero J, Romano A, Wei X, Lopez-Rios F, Von Hoff DD (2015). SPARC Expression Did Not Predict Efficacy of nab-Paclitaxel Plus Gemcitabine or Gemcitabine Alone for Metastatic Pancreatic Cancer in an Exploratory Analysis of the Phase III MPACT Trial.. Clin Cancer Res 21, 4811-4818.
Ceccon M, Merlo ME, Mologni L, Poggio T, Varesio LM, Menotti M., Bombelli S, Rigolio R, Manazza AD, DiGiacomo F, Ambrogio C, Giudici G, Casati C, Mastini C, Compagno M, Turner SD, Gambacorti-Passerini C, Chiarle R, Voena C (2015). Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency. Oncogene (in press).
Jeannot P, Callot C, Romain Baer R, Duquesnes N, Guerra C, Guillermet-Guibert J, Bachs O, Besson A (2015). Loss of p27Kip1 promotes metaplasia in the pancreas via the regulation of Sox9 expression.. Oncotarget 6, 35880-35882.
Pathria P, Gotthardt D, Prchal-Murphy M, Putz EM, Holcmann M, Schlederer M, Grabner B, Crncec I, Svinka J, Musteanu M, Hoffmann T, Filipits M, Berger W, Poli V, Kenner L, Bilban M, Casanova E, Müller M, Strobl B, Bayer E, Mohr T, Sexl V, Eferl R (2015). Myeloid STAT3 promotes formation of colitis-associated colorectal cancer in mice.. Oncoimmunology 4, e998529.
Viera A, Alsheimer M, Gómez R, Berenguer I, Ortega S, Symonds CE, Santamaría D, Benavente R, Suja JA (2015). CDK2 regulates nuclear envelope protein dynamics and telomere attachment in mouse meiotic prophase.. J Cell Sci 128, 88-99.
Agudo-Ibáñez L, Herrero A, Barbacid M, Crespo P (2015). H-ras distribution and signaling in plasma membrane microdomains are regulated by acylation and deacylation events.. Mol Cell Biol 35, 1898-1914.
Voena C, Menotti M, Mastini C, Di Giacomo F, Longo DL, Castella B, Merlo ME, Ambrogio C, Wang Q, Minero VG, Poggio T, Martinengo C, D'Amico L,Panizza E, Mologni L, Cavallo F, Altruda F, Butaney M,Capelletti M, Inghirami G, Jänne PA, Chiarle R (2015). Efficacy of a Cancer Vaccine against ALK-Rearranged Lung Tumors.. Cancer Immunol Res 3, 1333-1343.
Xie T, Musteanu M, Lopez-Casas PP, Shields DJ, Olson P, Rejto PA, Hidalgo M (2015). Whole Exome Sequencing of Rapid Autopsy Tumors and Xenograft Models Reveals Possible Driver Mutations Underlying Tumor Progression.. PLoS ONE 10, e0142631.
Ambrogio C, Cámara JA, Nieto P, Santamaría D, Mulero F (2015). Analysis of Murine Lung Tumors by Micro PET-CT Imaging.. Bioprotocol 5, E1692.
Drosten M, Barbacid M (2015). Ras and p53: an unsuspected liaison.. Molecular Cellular Oncology (in press).
Hernández-Porras I, Jiménez-Catalán B, Schuhmacher AJ, Guerra C (2015). The impact of the genetic background in the Noonan syndrome phenotype induced by K-Ras(V14I).. RARE DISEASES 3, e1045169.
Hermann PC, Sancho P, Cañamero M, Martinelli P, Madriles F, Michl P, Gress T, de Pascual R, Gandia L, Guerra C, Barbacid M, Wagner M, Vieira CR, Aicher A, Real FX, Sainz B Jr, Heeschen C (2014). Nicotine Promotes Initiation and Progression of KRAS-Induced Pancreatic Cancer via Gata6-Dependent Dedifferentiation of Acinar Cells in Mice.. Gastroenterology 147, 1119-1133.
Hu W, Nevzorova YA, Haas U, Moro N, Sicinski P, Geng Y, Barbacid M, Trautwein C, Liedtke C (2014). Concurrent deletion of cyclin E1 and cyclin-dependent kinase 2 in hepatocytes inhibits DNA replication and liver regeneration in mice.. Hepatology 59, 651-660.
Drosten M, Sum EY, Lechuga CG, Simón-Carrasco L, Jacob HK, García-Medina R, Huang S, Beijersbergen RL, Bernards R, Barbacid M (2014). Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway.. Proc Natl Acad Sci USA 111, 15155-15160.
Hernández-Porras I, Fabbiano S, Schuhmacher AJ, Aicher A, Cañamero M, Cámara JA, Cussó L, Desco M, Heeschen C, Mulero F, Bustelo XR, Guerra C, Barbacid M (2014). K-RasV14I recapitulates Noonan syndrome in mice.. Proc Natl Acad Sci USA 111, 16395-16400.
Mainardi S, Mijimolle N, Francoz S, Vicente-Dueñas C, Sánchez-García I, Barbacid M (2014). Identification of cancer initiating cells in K-Ras driven lung adenocarcinoma.. Proc Natl Acad Sci USA 111, 255-260.
Ambrogio C, Carmona FJ, Vidal A, Falcone M, Nieto P, Romero OA, Puertas S, Vizoso M, Nadal E, Poggio T, Sanchez-Cespedes M, Esteller M, Mulero F, Voena C, Chiarle R, Barbacid M, Santamaria D, Villanueva A (2014). Modeling Lung Cancer Evolution and Pre-Clinical Response By Orthotopic Mouse Allografts.. Cancer Res 74, 5978-5988.
Martínez-Bosch N, Fernández-Barrena MG, Moreno M, Ortiz-Zapater E, Munné-Collado J, Iglesias M, André S, Gabius HJ, Hwang RF, Poirier F, Navas C, Guerra C, Fernández-Zapico ME, Navarro P (2014). Galectin-1 Drives Pancreatic Carcinogenesis through Stroma Remodeling and Hedgehog Signaling Activation.. Cancer Res 74, 3512-3524.
Drosten M, Lechuga CG, Barbacid M (2014). Ras signaling is essential for skin development.. Oncogene 33, 2587-2865.
Martínez-Bosch N, Iglesias M, Munné-Collado J, Martínez-Cáceres C, Moreno M, Guerra C, Yélamos J, Navarro P (2014). Parp-1 genetic ablation in Ela-myc mice unveils novel roles for Parp-1 in pancreatic cancer.. J Pathol 234, 214-217.
Drosten M, Lechuga CG, Barbacid M (2014). Ras in epidermal proliferation.. Oncotarget 5, 5194-5195.
Lawler M, Le Chevalier T, Murphy MJ Jr, Banks I, Conte P, De Lorenzo F, Meunier F, Pinedo HM, Selby P, Armand JP, Barbacid M, Barzach M, Bergh J, Bode G, Cameron DA, de Braud F, de Gramont A, Diehl V, Diler S, Erdem S, Fitzpatrick JM, Geissler J, Hollywood D, Højgaard L, Horgan D, Jassem J, Johnson PW, Kapitein P, Kelly J, Kloezen S, La Vecchia C, Löwenberg B, Oliver K, Sullivan R, Tabernero J, Van de Velde CJ, Wilking N, Wilson R, Zielinski C, Zur Hausen H, Johnston PG (2014). A catalyst for change: the European cancer patient’s Bill of rights.. Oncologist 19, 217-224.
Alvarez R, Musteanu M, Garcia-Garcia E, Lopez-Casas PP, Megias D, Guerra C, Muñoz M, Quijano Y, Cubillo A, Rodriguez-Pascual J, Plaza C, de Vicente E, Prados S, Tabernero S, Barbacid M, Lopez-Rios F, Hidalgo M (2014). Reply: ‘Comments on Stromal disrupting effects of nab-paclitaxel in pancreatic cancer’. Br J Cancer 111, 1677-1678.
Cerqueira A, Martín A, Symonds CE, Odajima J, Dubus P, Barbacid M, Santamaría D (2014). Genetic characterization of the role of the Cip/Kip family of proteins as Cdk inhibitors and assembly factors.. Mol Cell Biol 34, 1452-1459.
Marino F, Orecchia V, Regis G, Musteanu M, Tassone B, Jon C, Forni M, Calautti E, Chiarle R, Eferl R, Poli V (2014). STAT3ß controls inflammatory responses and early tumor onset in skin and colon experimental cancer models.. Am J Cancer Res 4, 484-494.
Ambrogio C, Stern P, Scuoppo C, Kranz H, Barbacid M, Santamaría D (2014). Lentiviral-based approach for the validation of cancer therapeutic targets in vivo.. Biotechniques 57, 179.
Berns A, Barbacid M (2013). Mouse models of cancer.. Mol Oncol 7, 232-247.
Guerra C, Barbacid M (2013). Genetically engineered mouse models of pancreatic adenocarcinoma.. Mol Oncol 7, 232-247.
Alvarez R, Musteanu M, Garcia-Garcia E, Lopez-Casas PP, Megias D, Guerra C, Muñoz M, Quijano Y, Cubillo A, Rodriguez-Pascual J, Plaza C, de Vicente E, Prados S, Tabernero S, Barbacid M, Lopez-Rios F, Hidalgo M (2013). Stromal disrupting effects of nab-paclitaxel in pancreatic cancer.. Br J Cancer 109, 926-933.
Azrak SS, Ginel-Picardo A, Drosten M, Barbacid M, Santos E (2013). Reversible, interrelated mRNA and miRNA expression patterns in the transcriptome of Rasless fibroblasts: functional and mechanistic implications.. Bmc Genomics 14, 731.
González-Sánchez E, Martín-Caballero J, Flores JM, Hernández-Losa J; Ma Ángeles Montero, Cortés J, Mares R, Barbacid M, Recio JA (2013). Lkb1 Loss Promotes Tumor Progression of BRAFV600E-Induced Lung Adenomas.. PLoS ONE 8, e66933.
Drosten M, Lechuga CG, Barbacid M (2013). Genetic analysis of Ras genes in epidermal development and tumorigenesis.. Small GTPases 4, 4.