Familial Cancer Clinical Unit

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María Currás
María Currás Head of Clinical Unit
T +34 917328000 (Ext )
mcurras@cnio.es

Post-Doctoral Fellows

  • Bruna Calsina

Technicians

  • Verónica García
  • Eduardo Gil
  • Miguel Ángel Grillo
  • Fátima Mercadillo
  • Pilar Redondo

The activity of the Familial Cancer Clinical Unit (FCCU) is divided into 2 main areas:

  1. Genetic diagnosis in patients with suspected hereditary cancer using next-generation sequencing. 52% of our activity is dedicated to genetic diagnosis in the Familial Cancer Clinic of the University Hospital of Fuenlabrada (FCC-UHF), and 48% to providing this service to other hospitals in Madrid and the rest of Spain. Fifty-nine percent of the genetic diagnoses were carried out in index cases, while 41% were predictive studies in relatives to determine if they are carriers of a variant. We completed 203 urgent case studies to guide surgery and/or treatment, with results reported in less than 6-8 weeks. We also performed up to 50 extensions of previous studies (gene updates/tumour) and 67 variant reclassification reports (genetic information updates). 
  2. Research work. We participated in the identification of genetic factors and the interpretation of genetic variants of unknown significance (VUS) in the PTEN Hamartoma Tumour Syndrome (PHTS). We are involved in the IMPaCT-GENóMICA and IMPACT-VUSCan projects, having been one of the main participants in the Spanish Hereditary Cancer Variants Database (SpadaHC).

Publications

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