Home | Research & Innovation | Scientific Programmes | Biotechnology Programme | Proteomics Core Unit
Technicians
- Fernando García
- Laura Cynthia Woods
- Eduardo Zarzuela
Proteomics is acquiring a critical role in the comprehensive understanding of human biology. The rapid development of mass spectrometry-based proteomics instrumentation and data analysis pipelines has enabled the scientific community to delve deeper into the proteome than ever before. In the last decade, the output of proteomics studies has evolved from long lists of proteins to the generation of full statistically robust analyses, allowing proteomics to become truly functional. For example, cancer proteomics has unravelled key data on the mechanisms underlying tumour growth and metastasis, contributing to the identification of clinical biomarkers and novel therapeutic targets. The CNIO Proteomics Core Unit develops and applies state-of-the-art proteomics, bioinformatics and related technologies for the direct interrogation of proteome expression, modification, and function in cell-based models of human cancer. In collaboration with CNIO investigators, the Unit aims to provide valuable guidance for experimental strategies, which are critical for cancer research success.
Publications
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- Xia Q, Casas-Martinez JC, Zarzuela E, Muñoz J, Miranda-Vizuete A, Goljanek-Whysall K, McDonagh B. (2023). Peroxiredoxin 2 is required for the redox mediated adaptation to exercise. Redox Biol 60, 102631. CNIO Publication.
- Ibars E, Codina-Fabra J, Bellí G, Casas C, Tarrés M, Solé-Soler R, Lorite NP, Ximénez-Embún P, Muñoz J, Colomina N, Torres-Rosell J. (2023). Ubiquitin proteomics identifies RNA polymerase I as a target of the Smc5/6 complex. Cell Reports 42, 112463. CNIO Publication.
Open Access - Peinado-Izaguerri J, Zarzuela E, McLaughlin M, Small AC, Riva F, McKeegan DEF, Bain M, Muñoz J, Bhide M, Preston T. (2023). A novel dynamic proteomics approach for the measurement of broiler chicken protein fractional synthesis rate. Rapid Commun Mass Spectrom 37, e9497. CNIO Publication. Open Access
- Morales-Sanfrutos J, Munoz J (2022). Unravelling the complexity of the extracellular vesicle landscape with advanced proteomics. Expert Rev Proteomic 19, 89-101. CNIO Publication.
- Cerezo-Wallis D, Contreras-Alcalde M, Troulé K, Catena X, Mucientes C, Calvo TG, Cañón E, Tejedo C, Pennacchi PC, Hogan S, Kölblinger P, Tejero H, Chen AX, Ibarz N, Graña-Castro O, Martinez L, Muñoz J, Ortiz-Romero P, Rodriguez-Peralto JL, Gómez-López G, Al-Shahrour F, Rabadán R, Levesque MP, Olmeda D, Soengas MS. (2020). Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state. Nat Med 26, 1865-1877. CNIO Publication.
- Lynch CJ, Bernad R, Martínez-Val A, Shahbazi MN, Nóbrega-Pereira S, Calvo I, Blanco-Aparicio C, Tarantino C, Garreta E, Richart-Ginés L, Alcazar N, Graña-Castro O, Gómez-Lopez G, Aksoy I, Muñoz-Martín M, Martinez S, Ortega S, Prieto S, Simboeck E, Camasses A, Stephan-Otto Attolini C, Fernandez AF, Sierra MI, Fraga MF, Pastor J, Fisher D, Montserrat N, Savatier P, Muñoz J, Zernicka-Goetz M, Serrano M (2020). Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases. Nat Cell Biol 22, 1223-1238. CNIO Publication.
- Baliñas-Gavira C, Rodríguez MI, Andrades A, Cuadros M, Álvarez-Pérez JC, Álvarez-Prado ÁF, de Yébenes VG, Sánchez-Hernández S, Fernández-Vigo E, Muñoz J, Martín F, Ramiro AR, Martínez-Climent JA, Medina PP (2020). Frequent mutations in the amino-terminal domain of BCL7A impair its tumor suppressor role in DLBCL.. Leukemia 34, 2722-2735. CNIO Publication.
- Cash TP, Alcalá S, Rico-Ferreira MDR, Hernández-Encinas E, García J, Albarrán MI, Valle S, Muñoz J, Martínez-González S, Blanco-Aparicio C, Pastor J, Serrano M, Sainz B Jr (2020). Induction of Lysosome Membrane Permeabilization as a Therapeutic Strategy to Target Pancreatic Cancer Stem Cells. Cancers 12, 1790. CNIO Publication. Open Access
- Eslava-Alcon S, Extremera-García MJ, Sanchez-Gomar I, Beltrán-Camacho L, Rosal-Vela A, Muñoz J, Ibarz N, Alonso-Piñero JA, Rojas-Torres M, Jiménez-Palomares M, González-Rovira A, Conejero R, Doiz E, Rodriguez-Piñero M, Moreno-Luna R, Durán-Ruiz MC (2020). Atherosclerotic pre-conditioning affects the paracrine role of circulating angiogenic cells ex-vivo.. Int J Mol Sci 21, 5256. CNIO Publication.
- Ma W, Gil HJ, Escobedo N, Benito-Martín A, Ximénez-Embún P, Muñoz J, Peinado H, Rockson SG, Oliver G (2020). Platelet factor 4 is a biomarker for lymphatic-promoted disorders.. JCI Insight 5, e135109. CNIO Publication.
