- Francisco Javier Sánchez
- Cristina Sayago
- Fernando García
- Jana Sánchez
- Álvaro Soriano
- Maria Pilar Ximénez de Embún
- Eduardo Zarzuela
Proteins are the molecular effectors of cells and catalyse almost all biological processes. The levels of protein abundance, together with their modification states and interactions, adapt dynamically to external or internal ( genetic ) stimuli and thus define the cell’s functional state and determine its phenotype. Mass spectrometry-based proteomics is the most powerful tool to study the proteome, providing fundamental basic biology information. In addition, recent improvements in sensitivity and throughput now enable the analysis of larger cohorts of samples including biopsies, thereby making proteomics a part of the clinical research toolbox. All these efforts are providing new insights into the molecular mechanisms underlying cancer development as well as the identification of novel biomarkers.
- (2019). Evolution of Yin and Yang isoforms of a chromatin remodeling subunit precedes the creation of two genes.. Elife (in press). CNIO Publication.
- (2019). Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3.. Cell Reports 27, 3956-3971. CNIO Publication. Open Access
- (2019). p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.. Cancer Cell 35, 46-63. CNIO Publication.
- (2019). Proteotyping pluripotency with mass spectrometry. Expert Rev Proteomic (in press). CNIO Publication.
- (2018). In vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer. Nat Commun 9, 3501. CNIO Publication. Open Access
- (2018). In-Depth Proteomic Characterization of Classical and Non-Classical Monocyte Subsets. Proteomes 6, E8. CNIO Publication. Open Access
- (2018). Thrombocytopenia-associated mutations in Ser/Thr kinase MASTL deregulate actin cytoskeleton dynamics in platelets. J Clin Invest 128, 5351-5367. CNIO Publication. Open Access
- (2018). The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity. Cell Reports 22, 396-410. CNIO Publication. Open Access
- (2018). STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis. Nat Med 24, 1024-1035. CNIO Publication.
- (2017). Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine.. Nature 546, 676-680. CNIO Publication.
- (2017). mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.. Nature 547, 109-113. CNIO Publication.
- (2017). The molecular pathogenesis of the NUP98-HOXA9 fusion protein in acute myeloid leukemia.. Leukemia 31, 2000-2005. CNIO Publication.
- (2017). Urea Artifacts Interfere with Immuno-Purification of Lysine Acetylation.. J Proteome Res 16, 1061-1068. CNIO Publication.
- (2017). A multicentric study to evaluate the use of relative retention times in targeted proteomics.. J Proteomics 152, 138-149. CNIO Publication.
- (2016). USP7 is a SUMO deubiquitinase essential for DNA replication.. Nat Struct Mol Biol 23, 270-277. CNIO Publication.
- (2016). Targeting Tumor Mitochondrial Metabolism Overcomes Resistance to Antiangiogenics. Cell Reports 15, 2705-2718. CNIO Publication. Open Access
- (2016). On the Statistical Significance of Compressed Ratios in Isobaric Labeling: A Cross-Platform Comparison.. J Proteome Res 15, 3029-3038. CNIO Publication.
- (2015). CD24 tracks divergent pluripotent states in mouse and human cells.. Nat Communications 6, 7329. CNIO Publication.
- (2015). Rb and FZR1/Cdh1 determine CDK4/6-cyclin D requirement in C. elegans and human cancer cells. Nat Communications 6, 5906. CNIO Publication.
- (2015). Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2.. Genes Dev 29, 144-156. CNIO Publication.
- (2015). DAZL regulates Tet1 translation in murine embryonic stem cells.. EMBO Rep 16, 791-802. CNIO Publication.
- (2015). DAZL Limits Pluripotency, Differentiation, and Apoptosis in Developing Primordial Germ Cells.. Stem Cell Reports 3, 892-904. CNIO Publication.
- (2015). Fluctuations in histone H4 isoforms during cellular reprogramming monitored by middle-down proteomics.. Proteomics (in press). CNIO Publication.
- (2014). Genome-wide characterization of the routes to pluripotency.. Nature 516, 198-206. Publication in other institutions.
- (2014). Inhibition of De Novo NAD+ Synthesis by Oncogenic URI Causes Liver Tumorigenesis through DNA Damage.. Cancer Cell 26, 826-839. CNIO Publication.
- (2014). Proteome adaptation in cell reprogramming proceeds via distinct transcriptional networks.. Nat Communications 5, 5613. Publication in other institutions.
- (2014). Small RNA changes en route to distinct cellular states of induced pluripotency.. Nat Communications 5, 5522. Publication in other institutions.
- (2014). From the Human Genome to the Human Proteome.. Angewandte Chemie 53, 10864-10866. CNIO Publication.
- (2014). A synthetic lethal interaction between APC/C and topoisomerase poisons uncovered by proteomic screens.. Cell Reports 6, 670-683. CNIO Publication.
- (2014). CUL4A contributes to the biology of basal-like breast tumors through modulation of cell growth and antitumor immune response.. Oncotarget 5, 2330-2343. CNIO Publication.