Home | Research & Innovation | Scientific Programmes | Biotechnology Programme | Proteomics Core Unit
Technicians
- Fernando García
- Ileana Beatriz González
- Laura Cynthia Woods
- Eduardo Zarzuela
Proteomics has become a cornerstone of modern biological research, offering dynamic insights that extend beyond genomics. Advances in mass spectrometry, bioinformatics, and data analysis have transformed proteomics into a powerful tool for deciphering disease mechanisms, identifying biomarkers, and discovering therapeutic targets. By systematically navigating the proteome’s vast complexity, researchers can uncover hidden layers of protein expression, modifications, and interactions, providing a comprehensive view of cellular processes and their regulation.
The CNIO Proteomics Core Unit is at the forefront of this transformation, leveraging cutting-edge technologies to tackle fundamental questions in cancer biology. The recent acquisition of the Orbitrap Astral mass spectrometer marks a major milestone, delivering unprecedented sensitivity, depth, and throughput for large-scale, high-resolution proteomic studies. Through close collaboration with CNIO investigators, we integrate quantitative proteomics, functional analyses, and advanced bioinformatics to drive high-impact discoveries that advance cancer research and precision medicine.
Recent publications
- Aguilar-Garrido P, Velasco-Estévez M, Navarro-Aguadero MÁ, Otero-Sobrino A, Ibañez-Navarro M, Marugal MÁ, Hernández-Sánchez M, Malaney P, Rodriguez A, Benitez O, Zhang X, Aitken MJ, Ortiz-Ruiz A, Megias D, Pérez-Martínez M, Mata G, Gomez J, Lafarga M, Dominguez O, Graña-Castro O, Caleiras E, Ximenez-Embun P, Isasa M, de Andrés PJ, Rodriguez-Perales S, Torres-Ruiz R, Revilla E, García-Martín RM, Azorín D, Zubicaray J, Sevilla J, Sirozh O, Lafarga V, Martinez-Lopez J, Post SM, Gallardo M. (2025). The tumor suppressor HNRNPK induces p53-dependent nucleolar stress to drive ribosomopathies. J Clin Invest 135, e183697. CNIO Publication.
- Xia Q, Casas-Martinez JC, Zarzuela E, Muñoz J, Miranda-Vizuete A, Goljanek-Whysall K, McDonagh B. (2023). Peroxiredoxin 2 is required for the redox mediated adaptation to exercise. Redox Biol 60, 102631. CNIO Publication.
- Ibars E, Codina-Fabra J, Bellí G, Casas C, Tarrés M, Solé-Soler R, Lorite NP, Ximénez-Embún P, Muñoz J, Colomina N, Torres-Rosell J. (2023). Ubiquitin proteomics identifies RNA polymerase I as a target of the Smc5/6 complex. Cell Reports 42, 112463. CNIO Publication.
Open Access - Peinado-Izaguerri J, Zarzuela E, McLaughlin M, Small AC, Riva F, McKeegan DEF, Bain M, Muñoz J, Bhide M, Preston T. (2023). A novel dynamic proteomics approach for the measurement of broiler chicken protein fractional synthesis rate. Rapid Commun Mass Spectrom 37, e9497. CNIO Publication. Open Access
- Morales-Sanfrutos J, Munoz J (2022). Unravelling the complexity of the extracellular vesicle landscape with advanced proteomics. Expert Rev Proteomic 19, 89-101. CNIO Publication.
