“Este contenido se encuentra unicamente en inglés”
- Ana Martínez
- Cristina Sayago
Técnicos de Laboratorio
- Elvira Fernández-Vigo
- Fernando García
- Nuria Ibarz
- Álvaro Soriano
- Maria Pilar Ximénez de Embún
- Eduardo Zarzuela
Proteins are the molecular effectors of cells and catalyse almost all biological processes. The levels of protein abundance, together with their modification states and interactions, adapt dynamically to external or internal (genetic) stimuli and thus define the cell’s functional state and determine its phenotype. Mass spectrometrybased proteomics is the most powerful tool to study the proteome, providing fundamental information of basic biology. In addition, recent improvements in sensitivity and throughput now allow the analysis of larger cohorts of samples including biopsies, thus fully integrating proteomics into the clinical research toolbox. All these efforts have led to the provision of new insights into the molecular mechanisms underlying cancer development as well as the identification of novel biomarkers.
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Proteomes 6, E8-.
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Nat Commun 9, 3501-.
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Nature 546, 676-680.
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Nature 547, 109-113.
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J Proteome Res 16, 1061-1068.
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J Proteomics 152, 138-149.
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Nat Struct Mol Biol 23, 270-277.
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Cell Reports 15, 2705-2718.
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Nat Communications 5, 5613-.
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