Inicio | Investigación e innovación | Programas Científicos | Programa de Biotecnología | Unidad de Proteómica
Técnicos de Laboratorio
- Fernando García
- Laura Cynthia Woods
- Eduardo Zarzuela
Proteomics is acquiring a critical role in the comprehensive understanding of human biology. The rapid development of mass spectrometry-based proteomics instrumentation and data analysis pipelines has enabled the scientific community to delve deeper into the proteome than ever before. In the last decade, the output of proteomics studies has evolved from long lists of proteins to the generation of full statistically robust analyses, allowing proteomics to become truly functional. For example, cancer proteomics has unravelled key data on the mechanisms underlying tumour growth and metastasis, contributing to the identification of clinical biomarkers and novel therapeutic targets. The CNIO Proteomics Core Unit develops and applies state-of-the-art proteomics, bioinformatics and related technologies for the direct interrogation of proteome expression, modification, and function in cell-based models of human cancer. In collaboration with CNIO investigators, the Unit aims to provide valuable guidance for experimental strategies, which are critical for cancer research success.
Publicaciones
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- Xia Q, Casas-Martinez JC, Zarzuela E, Muñoz J, Miranda-Vizuete A, Goljanek-Whysall K, McDonagh B. (2023). Peroxiredoxin 2 is required for the redox mediated adaptation to exercise. Redox Biol 60, 102631. Publicación CNIO.
- Ibars E, Codina-Fabra J, Bellí G, Casas C, Tarrés M, Solé-Soler R, Lorite NP, Ximénez-Embún P, Muñoz J, Colomina N, Torres-Rosell J. (2023). Ubiquitin proteomics identifies RNA polymerase I as a target of the Smc5/6 complex. Cell Reports 42, 112463. Publicación CNIO.
Open Access - Peinado-Izaguerri J, Zarzuela E, McLaughlin M, Small AC, Riva F, McKeegan DEF, Bain M, Muñoz J, Bhide M, Preston T. (2023). A novel dynamic proteomics approach for the measurement of broiler chicken protein fractional synthesis rate. Rapid Commun Mass Spectrom 37, e9497. Publicación CNIO. Open Access
- Morales-Sanfrutos J, Munoz J (2022). Unravelling the complexity of the extracellular vesicle landscape with advanced proteomics. Expert Rev Proteomic 19, 89-101. Publicación CNIO.
- Cerezo-Wallis D, Contreras-Alcalde M, Troulé K, Catena X, Mucientes C, Calvo TG, Cañón E, Tejedo C, Pennacchi PC, Hogan S, Kölblinger P, Tejero H, Chen AX, Ibarz N, Graña-Castro O, Martinez L, Muñoz J, Ortiz-Romero P, Rodriguez-Peralto JL, Gómez-López G, Al-Shahrour F, Rabadán R, Levesque MP, Olmeda D, Soengas MS. (2020). Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state. Nat Med 26, 1865-1877. Publicación CNIO.
- Lynch CJ, Bernad R, Martínez-Val A, Shahbazi MN, Nóbrega-Pereira S, Calvo I, Blanco-Aparicio C, Tarantino C, Garreta E, Richart-Ginés L, Alcazar N, Graña-Castro O, Gómez-Lopez G, Aksoy I, Muñoz-Martín M, Martinez S, Ortega S, Prieto S, Simboeck E, Camasses A, Stephan-Otto Attolini C, Fernandez AF, Sierra MI, Fraga MF, Pastor J, Fisher D, Montserrat N, Savatier P, Muñoz J, Zernicka-Goetz M, Serrano M (2020). Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases. Nat Cell Biol 22, 1223-1238. Publicación CNIO.
- Baliñas-Gavira C, Rodríguez MI, Andrades A, Cuadros M, Álvarez-Pérez JC, Álvarez-Prado ÁF, de Yébenes VG, Sánchez-Hernández S, Fernández-Vigo E, Muñoz J, Martín F, Ramiro AR, Martínez-Climent JA, Medina PP (2020). Frequent mutations in the amino-terminal domain of BCL7A impair its tumor suppressor role in DLBCL.. Leukemia 34, 2722-2735. Publicación CNIO.
- Cash TP, Alcalá S, Rico-Ferreira MDR, Hernández-Encinas E, García J, Albarrán MI, Valle S, Muñoz J, Martínez-González S, Blanco-Aparicio C, Pastor J, Serrano M, Sainz B Jr (2020). Induction of Lysosome Membrane Permeabilization as a Therapeutic Strategy to Target Pancreatic Cancer Stem Cells. Cancers 12, 1790. Publicación CNIO. Open Access
- Eslava-Alcon S, Extremera-García MJ, Sanchez-Gomar I, Beltrán-Camacho L, Rosal-Vela A, Muñoz J, Ibarz N, Alonso-Piñero JA, Rojas-Torres M, Jiménez-Palomares M, González-Rovira A, Conejero R, Doiz E, Rodriguez-Piñero M, Moreno-Luna R, Durán-Ruiz MC (2020). Atherosclerotic pre-conditioning affects the paracrine role of circulating angiogenic cells ex-vivo.. Int J Mol Sci 21, 5256. Publicación CNIO.
- Ma W, Gil HJ, Escobedo N, Benito-Martín A, Ximénez-Embún P, Muñoz J, Peinado H, Rockson SG, Oliver G (2020). Platelet factor 4 is a biomarker for lymphatic-promoted disorders.. JCI Insight 5, e135109. Publicación CNIO.
- Karras P, Riveiro-Falkenbach E, Cañón E, Tejedo C, Calvo TG, Martínez-Herranz R, Alonso-Curbelo D, Cifdaloz M, Perez-Guijarro E, Gómez-López G, Ximenez-Embun P, Muñoz J, Megias D, Olmeda D, Moscat J, Ortiz-Romero PL, Rodríguez-Peralto JL, Soengas MS. (2019). p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.. Cancer Cell 35, 46-63. Publicación CNIO.
- Karras P, Riveiro-Falkenbach E, Cañón E, Tejedo C, Calvo TG, Martínez-Herranz R, Alonso-Curbelo D, Cifdaloz M, Perez-Guijarro E, Gómez-López G, Ximenez-Embun P, Muñoz J, Megias D, Olmeda D, Moscat J, Ortiz-Romero PL, Rodríguez-Peralto JL, Soengas MS (2019). p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors. Cancer Cell 35, 46-63. Publicación CNIO.
- García-Silva S, Benito-Martín A, Sánchez-Redondo S, Hernández-Barranco A, Ximénez-Embún P, Nogués L, Mazariegos MS, Brinkmann K, Amor López A, Meyer L, Rodríguez C, García-Martín C, Boskovic J, Letón R, Montero C, Robledo M, Santambrogio L, Sue Brady M, Szumera-Cieckiewicz A, Kalinowska I, Skog J, Noerholm M, Muñoz J, Ortiz-Romero PL, Ruano Y, Rodríguez-Peralto JL, Rutkowski P, Peinado H (2019). Use of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and BRAF V600E mutation. J Exp Med 216, 1061-1070. Publicación CNIO.
- Ucero AC, Bakiri L, Roediger B, Suzuki M, Jimenez M, Mandal P, Braghetta P, Bonaldo P, Paz-Ares L, Fustero-Torre C, Ximenez-Embun P, Hernandez AI, Megias D, Wagner EF (2019). Fra-2-expressing macrophages promote lung fibrosis in mice. J Clin Invest 129, 3293-3309. Publicación CNIO.
- Borghesan M, Fafián-Labora J, Eleftheriadou O, Carpintero-Fernández P, Paez-Ribes M, Vizcay-Barrena G, Swisa A, Kolodkin-Gal D, Ximénez-Embún P, Lowe R, Martín-Martín B, Peinado H, Muñoz J, Fleck RA, Dor Y, Ben-Porath I, Vossenkamper A, Muñoz-Espin D, O'Loghlen A (2019). Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3.. Cell Reports 27, 3956-3971. Publicación CNIO. Open Access
- Xu W, Long L, Zhao Y, Stevens L, Felipe I, Munoz J, Ellis RE, McGrath PT (2019). Evolution of Yin and Yang isoforms of a chromatin remodeling subunit precedes the creation of two genes.. Elife 8, e48119. Publicación CNIO. Open Access
- Montero-Conde C, Graña-Castro O, Martín-Serrano G, Martínez-Montes ÁM, Zarzuela E, Muñoz J, Torres-Perez R, Pita G, Cordero-Barreal A, Leandro-García LJ, Letón R, de Silanes IL, Guadalix S, Pérez-Barrios A, Hawkins F, Guerrero-Álvarez A, Álvarez-Escolá C, Regojo-Zapata R, Calsina B, Remacha L, Roldán-Romero JM, Santos M, Lanillos J, Jordá M, Riesco-Eizaguirre G, Zafon C, González-Neira A, Blasco MA, Al-Shahrour F, Rodríguez-Antona C, Cascón A, Robledo M. (2019). Hsa-miR-139-5p is a prognostic thyroid cancer marker involved in HNRNPF-mediated alternative splicing.. Int J Cancer 146, 521-530. Publicación CNIO. Open Access
- Sayago C, Martinez-Val A, Munoz J (2019). Proteotyping pluripotency with mass spectrometry. Expert Rev Proteomic 16, 391-400. Publicación CNIO.
