Unidad de Proteómica

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Javier Muñoz

Técnicos de Laboratorio

  • Fernando García
  • Julia Isabel Morales
  • Jana Sánchez
  • Cristina Sayago
  • Maria Pilar Ximénez de Embún
  • Eduardo Zarzuela

Proteins act as the molecular effectors of cells and catalyse virtually all biological processes. In this regard, proteomics aims to characterise the complete repertoire of proteins to better understand how cells function at the molecular level. Global analysis of proteins is challenging, owing to their high complexity (>12,000 genes transcriptionally active in mammalian cells) and high dynamic range (9 orders of magnitude between high- and low-expressed proteins).

Furthermore, proteins are post-translationally modified (e.g. phosphorylation) and interact with each other to form complexes ; both processes are highly divergent in time and space. To tackle these analytical challenges, proteomics uses a combination of sample preparation, mass spectrometry (MS) and bioinformatics. The CNIO Proteomics Core Unit provides MS-based proteomics methodologies to research groups in order to better understand, at the proteome level, the underlying molecular basis of cancer.

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