The Crystallography and Protein Engineering Unit is a core facility that provides on-demand services at different levels, from the cloning, expression and purification of proteins to the determination of their 3D structures, with the purpose to fulfil the demands of our users and to understand the function of their protein targets. Thus, we produce proteins for different types of biochemical/biophysical/in vitro/in vivo assays, antibody generation, and structural determination at low resolution by small-angle X-ray scattering (SAXS) or at atomic resolution by X-ray crystallography. The latter includes protein co-crystallisation in the presence of inhibitors or small fragments, a method that we routinely combine with the quantification of protein thermal stability (thermofluor assay) to aid the drug discovery process.
Publications
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Open Access