Kinases, Protein Phosphorylation and Cancer Group

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Ivan Plaza Menacho
Ivan Plaza Menacho Group Leader
T +34 (+34) 917 328 000 (Ext 3030)

Post-Doctoral Fellows

  • Pablo Soriano

Graduate Students

  • Hipólito Nicolás Cuesta

Rational and precise targeting of oncogene driven signalling is a crucial and yet outstanding challenge in cancer research today. Understanding the structural and molecular bases of oncogene activation and signalling is key for the design and development of better therapeutics. Our research focuses on the structural and molecular understanding of protein kinase function: how protein kinases are activated and regulated by post-translational modifications and allosteric inputs, and how they assemble into macromolecular protein complexes to transmit signals inside the cell. We put a special emphasis on how these mechanisms are corrupted in cancer and disease due to oncogenic mutations and other oncogenic insults. Crucially, such atomic and molecular information can be translated into the design and development of more potent and specific protein kinase inhibitors, eventually leading to more effective drugs for the treatment of cancer patients.