Grupo de Quinasas, Fosforilación de Proteínas y Cáncer

Inicio | Investigación e innovación | Programas Científicos | Programa de Biología Estructural | Grupo de Quinasas, Fosforilación de Proteínas y Cáncer

Becarios Post-doctorales

  • Julia María Contreras
  • Rubén Julio Martínez

Becarios Pre-Doctorales

  • Hipólito Nicolás Cuesta
  • Ana Martín
  • Moustafa Ahmed Mohamed Shehata

Rational and precise targeting of oncogene-driven signalling is a crucial and, yet today, outstanding challenge in cancer research. Understanding the structural and molecular bases of oncogene activation and signalling is key for the design and development of better therapeutics. Our research focuses on the structural and molecular understanding of protein kinase function: (i) how protein kinases are activated and regulated by posttranslational modifications and allosteric inputs, and (ii) how they assemble into macromolecular protein complexes to transmit signals inside the cell. We put a special emphasis on how these mechanisms are corrupted in cancer and disease due to oncogenic mutations and other oncogenic insults. Crucially, such atomic and molecular information can be translated into the design and development of more potent and specific protein kinase inhibitors, eventually leading to more effective drugs for the treatment of cancer patients.