Home | Research & Innovation | Scientific Programmes | Structural Biology Programme | Biomolecular Design and Structural Nanomedicine Group

Research Scientists

  • Pablo San Segundo

Post-Doctoral Fellows

  • Laura Pérez-Chirinos

Our lab specializes in protein design, structural biology, and synthetic biology, leveraging AI-driven approaches to engineer protein cages, nanomachines, and other biomolecules with precise functions. By combining these innovations with detailed studies of viral structures, we explore new ways to manipulate biological systems.

Our goal is to translate these advances into nanomedicine, developing cutting-edge tools and therapeutic platforms that address critical challenges in cancer and human health.

Publications

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  • Gladkov N, Scott EA, Meador K, Lee EJ, Laganowsky AD, Yeates TO, Castells-Graells R. (2024). Design of a symmetry-broken tetrahedral protein cage by a method of internal steric occlusion. Protein Sci 33, e4973. Publication in other institutions.
  • Meador K, Castells-Graells R, Aguirre R, Sawaya MR, Arbing MA, Sherman T, Senarathne C, Yeates TO. (2024). A suite of designed protein cages using machine learning and protein fragment-based protocols. Structure 32, 751-765. Publication in other institutions.
  • Castells-Graells R, Hesketh EL, Matsui T, Johnson JE, Ranson NA, Lawson DM, Lomonossoff GP (2024). Unravelling the Maturation Pathway of a Eukaryotic Virus through Cryo-EM.. BioRxiv (in press). Publication in other institutions.
  • Castells-Graells R, Meador K, Arbing MA, Sawaya MR, Gee M, Cascio D, Gleave E, Debreczeni JÉ, Breed J, Leopold K, Patel A, Jahagirdar D, Lyons B, Subramaniam S, Phillips C, Yeates TO. (2023). Cryo-EM structure determination of small therapeutic protein targets at 3 Å-resolution using a rigid imaging scaffold. Proc Natl Acad Sci USA 120, e2305494120. Publication in other institutions.

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