Grupo de Diseño Biomolecular y Nanomedicina Estructural

Inicio | Investigación e innovación | Programas Científicos | Programa de Biología Estructural | Grupo de Diseño Biomolecular y Nanomedicina Estructural

Roger Castells
Roger Castells Jefe de Grupo
T +34 (+34) 917 328 000 (Ext )
rcastellsg@cnio.es

Investigadores Científicos

  • Pablo San Segundo

Becarios Pre-Doctorales

  • Miguel Sánchez

In the Biomolecular Design and Structural Nanomedicine Group, our research sits at the interface of protein design, structural biology, artificial intelligence (AI), and synthetic biology. We leverage AI-driven approaches to design novel protein cages, nanomachines, and therapeutic biomolecules with precise functions, and combine these with cryo-electron microscopy (cryo-EM) and studies of viral architectures to explore new ways of manipulating biological systems. Our goal is to understand fundamental processes in cancer and translate these advances into nanomedicine, developing cutting-edge tools and therapeutic platforms to address critical challenges in human health. Our research includes AI-driven biomolecular design of novel proteins for targeted therapeutic and diagnostic applications; cryo-EM methods development, including the creation of imaging scaffolds for the structure determination of small proteins; and structural nanomedicine, harnessing virus-like particles and designed protein cages for precision drug delivery and cancer therapy.

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