Home | Research & Innovation | Scientific Programmes | Tumour Biology Programme | Cancer Immunity Group
Post-Doctoral Fellows
- Marta Amorós
- Rafael Fenutria
- Ana Mantrana
- Sarai Martínez
Graduate Students
- Eduardo Garvín
- Jan Hochstadt
- Mariola Munárriz
- Maria Nogales Pons
Technicians
- Teresa Aceña
- David Cáceres
- Mónica Gómez
Our laboratory investigates how myeloid cells shape the microenvironment of solid tumours (lung, ovarian and breast cancer metastasis). We use unbiased approaches, such as single-cell RNA sequencing (scRNAseq), to identify novel biomarkers within this cell compartment that can be harnessed into the clinic to dampen immunosuppression. Our work also uncovers new physiological cues on the regulation of circadian immunity in lung cancer, clonal haematopoiesis in tumour-associated macrophage activity, as well as macrophage-fibroblast crosstalk in lung tumours.
This year, our Group made significant strides in advancing cancer research by contributing to the understanding of lung tumour biology, particularly with the identification of universal fibroblasts as key regulators of T-cell infiltration in non-small-cell lung cancer (NSCLC). This breakthrough discovery will pave the way to explore novel treatment approaches, all of which aim to improve early detection, treatment outcomes, and the overall response to immune checkpoint blockade.
Recent publications
- Garvin-Jiménez E, Casanova-Acebes M (2025). It takes two to TAM-go. Gut (in press). CNIO Publication.
- Navarrete-Sirvent C, Mantrana A, Rivas-Crespo A, Díaz-Chacón A, Herrera-Casanova NM, Sánchez-Montero MT, Toledano-Fonseca M, García-Ortiz MV, Ortiz-Morales MJ, Pulido G, Cano MT, Gómez-España A, González-Fernández R, Bourhis LL, Guil-Luna S, Rodríguez-Ariza A, Aranda E. (2025). Imbalanced NK cell subpopulations and TIGIT expression limit cetuximab efficacy in colorectal cancer: A promising target for treatment enhancement. Clin Transl Med 15, e70351. CNIO Publication.
- Hochstadt J, Martínez Pacheco S, Casanova-Acebes M. (2025). Embracing diversity: macrophage complexity in cancer. Trends in Cancer 11, 351-364. CNIO Publication.
- Ortega-Molina A, Lebrero-Fernández C, Sanz A, Calvo-Rubio M, Deleyto-Seldas N, de Prado-Rivas L, Plata-Gómez AB, Fernández-Florido E, González-García P, Vivas-García Y, Sánchez García E, Graña-Castro O, Price NL, Aroca-Crevillén A, Caleiras E, Monleón D, Borrás C, Casanova-Acebes M, de Cabo R, Efeyan A. (2024). A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation and shortened lifespan. Nature Aging 4, 1102-1120. CNIO Publication.
Open Access - Park MD, Reyes-Torres I, LeBerichel J, Hamon P, LaMarche NM, Hegde S, Belabed M, Troncoso L, Grout JA, Magen A, Humblin E, Nair A, Molgora M, Hou J, Newman JH, Farkas AM, Leader AM, Dawson T, D'Souza D, Hamel S, Sanchez-Paulete AR, Maier B, Bhardwaj N, Martin JC, Kamphorst AO, Kenigsberg E, Casanova-Acebes M, Horowitz A, Brown BD, De Andrade LF, Colonna M, Marron TU, Merad M (2023). TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer. Nat Immunol 24, 792-801. CNIO Publication. Open Access
- Grout JA, Sirven P, Leader AM, Maskey S, Hector E, Puisieux I, Steffan F, Cheng E, Tung N, Maurin M, Vaineau R, Karpf L, Plaud M, Begue AL, Ganesh K, Mesple J, Casanova-Acebes M, Tabachnikova A, Keerthivasan S, Lansky A, Le Berichel J, Walker L, Rahman AH, Gnjatic S, Girard N, Lefevre M, Damotte D, Adam J, Martin JC, Wolf A, Flores RM, Beasley MB, Pradhan R, Muller S, Marron TU, Turley SJ, Merad M, Kenigsberg E, Salmon H (2022). Spatial Positioning and Matrix Programs of Cancer-Associated Fibroblasts Promote T-cell Exclusion in Human Lung Tumors. Cancer Discovery 12, 2606-2625. CNIO Publication. Open Access
- Casanova-Acebes, M., Dalla, E., Leader, A.M, LeBerichel J, Nikolic J, Morales BM , Brown M, Chang C, Troncoso L, Chen ST, Sastre-Perona A, Park M, Tabachnikova A, Dhainaut M, Hamon P, Maier B, Sawai CM, Agulló-Pascual E, Chober M, Brown BD, Reizis B, Marron T, Kenigsberg E, Moussion C, Benaroch, Aguirre-Ghiso JA, Merad M (2021). Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells. Nature 595, 578-584. Publication in other institutions.
- Hidalgo A , Casanova-Acebes M (2021). Dimensions of neutrophil life and fate. Semin Immunol (in press). CNIO Publication.
