Myeloid cells are abundant in solid tumours. While their heterogeneity has been widely described, efficient ways of manipulating these cells are scarce. My laboratory focuses on the identification and therapeutic targeting of myeloid checkpoint programmes in cancer. By studying the microenvironment in which lung, ovarian, and breast cancer emerge, we examine how macrophages crosstalk with the stroma and how they modulate their malignant conversion into cancer-associated fibroblasts. As metastasis is the major cause of death in breast cancer, we explore the mechanisms by which neutrophils exacerbate metastasis malignancy. Lastly, understanding how tissue physiology is perturbed in cancer is key to investigating novel ways to modulate anti-tumour immunity: we do this by exploring the circadian biology of immune responses, interrogating how our diet modifies the lipid metabolism of macrophages, and mining the dysfunctional properties of bone marrow-derived haematopoiesis.
Publicaciones
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Park MD, Reyes-Torres I, LeBerichel J, Hamon P, LaMarche NM, Hegde S, Belabed M, Troncoso L, Grout JA, Magen A, Humblin E, Nair A, Molgora M, Hou J, Newman JH, Farkas AM, Leader AM, Dawson T, D'Souza D, Hamel S, Sanchez-Paulete AR, Maier B, Bhardwaj N, Martin JC, Kamphorst AO, Kenigsberg E, Casanova-Acebes M, Horowitz A, Brown BD, De Andrade LF, Colonna M, Marron TU, Merad M (2023).TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer. Nat Immunol 24, 792-801. Publicación CNIO. Open Access
Grout JA, Sirven P, Leader AM, Maskey S, Hector E, Puisieux I, Steffan F, Cheng E, Tung N, Maurin M, Vaineau R, Karpf L, Plaud M, Begue AL, Ganesh K, Mesple J, Casanova-Acebes M, Tabachnikova A, Keerthivasan S, Lansky A, Le Berichel J, Walker L, Rahman AH, Gnjatic S, Girard N, Lefevre M, Damotte D, Adam J, Martin JC, Wolf A, Flores RM, Beasley MB, Pradhan R, Muller S, Marron TU, Turley SJ, Merad M, Kenigsberg E, Salmon H (2022).Spatial Positioning and Matrix Programs of Cancer-Associated Fibroblasts Promote T-cell Exclusion in Human Lung Tumors. Cancer Discovery 12, 2606-2625. Publicación CNIO. Open Access
Casanova-Acebes, M., Dalla, E., Leader, A.M, LeBerichel J, Nikolic J, Morales BM , Brown M, Chang C, Troncoso L, Chen ST, Sastre-Perona A, Park M, Tabachnikova A, Dhainaut M, Hamon P, Maier B, Sawai CM, Agulló-Pascual E, Chober M, Brown BD, Reizis B, Marron T, Kenigsberg E, Moussion C, Benaroch, Aguirre-Ghiso JA, Merad M (2021).Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells. Nature 595, 578-584. Publicación en otras instituciones.
Open Access