The Genomics Unit is a core facility offering centralised research services and expert support across the broad field of genomics. These services span a wide range of applications, from basic to cutting-edge genomic technologies, helping researchers uncover biological complexity, therapeutic targets, and prognostic biomarkers. By leveraging the ability to analyse entire genomes and their activity, these technologies reveal the full spectrum of structural and functional features, including mutation landscapes, protein binding sites, chromatin architecture, and molecular programmes, either in bulk within a tumour or at single-cell resolution. Next-generation sequencing (NGS) is a staple technology across these approaches. In addition, the Unit operates a genotyping service for genetically modified mice widely used by research groups across the CNIO research community, ensuring comprehensive support for projects involving animal models.