- Purificación Arribas
- José Luis Espadas
- Guadalupe Luengo
- Jorge Monsech
- Ángeles Rubio
The aim of the Genomics Unit is to provide technological services in the fields of genomics and genetics. Technologies with the capacity to interrogate genomes and their activities in a single assay are available. Methodologies able to dissect active molecular hierarchies and pathways (transcriptomic RNA profiling) or structural variations (mutation landscapes, chromatin structure) for the study of cancer or other biological processes. Our services cover a broad range of applications. Next-generation sequencing (NGS) is a staple among them. It is being used for chromatin structure studies, chromosomal protein location analysis, and for transcriptome determinations even at the single-cell level. More traditional methodologies like Sanger capillary DNA sequencing are also provided. As a side activity, the Unit supports a genetically engineered mouse genotyping service.
- (2020). Immuno-priming durvalumab with bevacizumab in HER2-negative advanced breast cancer: a pilot clinical trial. Breast Cancer Res 22, 124. CNIO Publication. Open Access
- (2020). Comparative Study of Organoids from Patient-Derived Normal and Tumor Colon and Rectal Tissue. Cancers 12, 2302. CNIO Publication. Open Access
- (2019). Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity. Nat Commun 10, 4407. CNIO Publication. Open Access
- (2018). Exome Sequencing of Plasma DNA Portrays the Mutation Landscape of Colorectal Cancer and Discovers Mutated VEGFR2 Receptors as Modulators of Antiangiogenic Therapies. Clin Cancer Res 24, 3550-3559. CNIO Publication.
- (2018). ERF deletion rescues RAS deficiency in mouse embryonic stem cells. Genes Dev 32, 568-576. CNIO Publication. Open Access
- (2017). TrapSeq: An RNA Sequencing-Based Pipeline for the Identification of Gene-Trap Insertions in Mammalian Cells.. J Mol Biol 429, 2780-2789. CNIO Publication.