Genomics Core Unit

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Technicians

  • Purificación Arribas
  • Guadalupe Luengo
  • Jorge Monsech
  • Ángeles Rubio

The Genomics Unit provides centralised research services as well as expert consultation in the fields of genomics and genetics. Contributing to uncover biological mechanisms, therapeutic targets, or prognostic biomarkers, these services encompass a broad range of applications, from traditional to cutting-edge technologies. These technologies, with their capacity to interrogate whole genomes and their activities, can reveal the entire package of structural features (mutation landscapes, chromosomal protein location, or chromatin structure) and molecular programmes (transcriptomic RNA profiles), even at the single-cell level. So-called next-generation sequencing (NGS) is a staple among them. More traditional methodologies, like Sanger capillary DNA sequencing, are also provided. As a side activity, we manage a genetically engineered mouse genotyping service.

Publications

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  • Costales-Carrera A, Fernández-Barral A, Bustamante-Madrid P, Domínguez O, Guerra-Pastrián L, Cantero R, Del Peso L, Burgos A, Barbáchano A, Muñoz A (2020). Comparative Study of Organoids from Patient-Derived Normal and Tumor Colon and Rectal Tissue. Cancers 12, 2302. CNIO Publication. Open Access Open Access
  • Quintela-Fandino M, Holgado E, Manso L, Morales S, Bermejo B, Colomer R, Apala JV, Blanco R, Muñoz M, Caleiras E, Iranzo V, Martinez M, Dominguez O, Hornedo J, Gonzalez-Cortijo L, Cortes J, Gasol Cudos A, Malon D, Lopez-Alonso A, Moreno-Ortíz MC, Mouron S, Mañes S (2020). Immuno-priming durvalumab with bevacizumab in HER2-negative advanced breast cancer: a pilot clinical trial. Breast Cancer Res 22, 124. CNIO Publication. Open Access Open Access
  • Fernández-Barral A, Costales-Carrera A, Buira SP, Jung P, Ferrer-Mayorga G, Larriba MJ, Bustamante-Madrid P, Domínguez O, Real FX, Guerra-Pastrián L, Lafarga M, García-Olmo D, Cantero R, Del Peso L, Batlle E, Rojo F, Muñoz A, Barbáchano A. (2020). Vitamin D differentially regulates colon stem cells in patient-derived normal and tumor organoids.. FEBS J 287, 53-72. CNIO Publication. Open Access Open Access
  • Santos CP, Lapi E, Martínez de Villarreal J, Álvaro-Espinosa L, Fernández-Barral A, Barbáchano A, Domínguez O, Laughney AM, Megías D, Muñoz A, Real FX (2019). Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity. Nat Commun 10, 4407. CNIO Publication. Open Access Open Access

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