Inicio | Investigación e innovación | Programas Científicos | Programa de Biotecnología | Unidad de Genómica
Técnicos de Laboratorio
- Purificación Arribas
- Guadalupe Luengo
- Jorge Monsech
- Ángeles Rubio
The Genomics Unit provides centralised research services and expert consultation in the expansive fields of genomics and genetics. These services encompass a broad range of applications, from traditional to the latest genomic technologies, and contribute to uncovering biological complexity, therapeutic targets, and prognostic biomarkers. Leveraging their capacity to scrutinise entire genomes and their activities, these technologies can reveal the whole spectrum of structural and functional features. These include mutation landscapes, protein binding to chromosomal locations, understanding chromatin structure, and deciphering molecular programmes such as transcriptomic RNA profiles, either in bulk within a tumour or at the single-cell level. Next-generation sequencing (NGS) is a staple among these technologies, while more traditional methodologies like Sanger capillary DNA sequencing are also provided. Additionally, the Unit manages a genotyping service for genetic models.
Publicaciones
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- Costales-Carrera A, Fernández-Barral A, Bustamante-Madrid P, Domínguez O, Guerra-Pastrián L, Cantero R, Del Peso L, Burgos A, Barbáchano A, Muñoz A (2020). Comparative Study of Organoids from Patient-Derived Normal and Tumor Colon and Rectal Tissue. Cancers 12, 2302. Publicación CNIO.
Open Access - Quintela-Fandino M, Holgado E, Manso L, Morales S, Bermejo B, Colomer R, Apala JV, Blanco R, Muñoz M, Caleiras E, Iranzo V, Martinez M, Dominguez O, Hornedo J, Gonzalez-Cortijo L, Cortes J, Gasol Cudos A, Malon D, Lopez-Alonso A, Moreno-Ortíz MC, Mouron S, Mañes S (2020). Immuno-priming durvalumab with bevacizumab in HER2-negative advanced breast cancer: a pilot clinical trial. Breast Cancer Res 22, 124. Publicación CNIO. Open Access
- Fernández-Barral A, Costales-Carrera A, Buira SP, Jung P, Ferrer-Mayorga G, Larriba MJ, Bustamante-Madrid P, Domínguez O, Real FX, Guerra-Pastrián L, Lafarga M, García-Olmo D, Cantero R, Del Peso L, Batlle E, Rojo F, Muñoz A, Barbáchano A. (2020). Vitamin D differentially regulates colon stem cells in patient-derived normal and tumor organoids.. FEBS J 287, 53-72. Publicación CNIO. Open Access
- Santos CP, Lapi E, Martínez de Villarreal J, Álvaro-Espinosa L, Fernández-Barral A, Barbáchano A, Domínguez O, Laughney AM, Megías D, Muñoz A, Real FX (2019). Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity. Nat Commun 10, 4407. Publicación CNIO. Open Access
