Our Group investigates how somatic mutations reshape cancer systems at the protein network level. We define large-scale protein–protein functional associations, including previously underappreciated negative interactions, to quantify mutation-driven network perturbations across more than 1,000 tumours. We integrate subclonal architecture with network propagation to develop AI-based models for treatment response prediction across therapies and cancer types. In parallel, we are establishing deep learning frameworks to predict protein–protein interactions from motif and sequence features, enabling scalable reconstruction of cancer-specific interactomes. Together, our work builds a systems-level platform linking mutation, network dynamics, and therapeutic outcome for precision oncology.
Post-Doctoral Fellows
- Seokjin Ham
- A-Reum Nam
Graduate Students
- Jaejun Lee
- Adrián Maqueda
- Manuel Moradiellos
Technicians
- Diego Sánchez
Recent publications
- (2026). A network-based deep learning model integrating subclonal architecture for therapy response prediction in cancer. Cell Rep Methods (in press). CNIO Publication.
- (2025). p53 protein degradation redefines the initiation mechanisms and drives transitional mutations in colorectal cancer. Nat Commun 16, 3934. CNIO Publication.
- (2025). Mapping cancer gene dynamics through state-specific interactions. Cell Reports 44, 115872. CNIO Publication.
- (2025). Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity. FEBS Open Bio 15, 1771-1788. CNIO Publication.
- (2023). Systematic analysis of disease-linked rare germline variants reveals new classes of cancer predisposing genes.. Genome Med 15, 107. CNIO Publication.
- (2023). Genetic assessment of pathogenic germline alterations in lysosomal genes among Asian patients with pancreatic ductal adenocarcinoma. J Transl Med 21, 730. CNIO Publication.
- (2021). Lipid-Oriented Live-Cell Distinction of B and T Lymphocytes. J Am Chem Soc 143, 5836-5844. CNIO Publication.
- (2021). Lipid-Oriented Live-Cell Distinction of B and T Lymphocytes. J Am Chem Soc 143, 5836-5844. CNIO Publication.
- (2021). Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers.. Nat Commun 12, 7051. CNIO Publication.
Open Access - (2021). A comprehensive analysis of prefoldins and their implication in cancer.. iScience 24, 103273. CNIO Publication. Open Access