Computational Cancer Genomics Group

Solip Park Group Leader
T +34 (+34) 917 328 000 (Ext )
solippark@cnio.es

Post-Doctoral Fellows

Seokjin Ham
A-Reum Nam

Graduate Students

Jaejun Lee
Adrián Maqueda
Manuel Moradiellos

Through big data analysis on cancer patients, we aim to address a fundamental question:
do identical genes or mutations exhibit the same effects in different cellular contexts
? The optimal fitness level of a cancer gene can vary based on the context, and to deepen our understanding, we apply quantitative methods to explore it. First, we investigate how the fitness landscape shifts between primary and metastatic cancers by analysing the combination of alterations. Next, we seek to unravel how the position of mutations affects protein interaction partners and how these perturbations impact phenotypic outcomes. For this, we build a model that leverages state-of-the-art AI-based structural predictions and multi-omics data. Through this interdisciplinary approach, our goal is to gain insights into the diverse modes of action that genes may assume, ultimately contributing to the development of patient-specific treatments and preventive strategies.

Recent publications

Herranz-Montoya I, Angulo-Aguado M, Perna C, Zagorac S, García-Jimeno L, Park S, Djouder N. (2025). p53 protein degradation redefines the initiation mechanisms and drives transitional mutations in colorectal cancer. Nat Commun 16, 3934. CNIO Publication.
Cabezudo S, Cuervo N, García-Martín C, López-Perrote A, Reglero C, Maqueda-Real A, González-Corpas A, Serna M, Megías D, Efeyan A, Park S, Llorca O. (2025). Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity. FEBS Open Bio (in press). CNIO Publication.
Song S, Koh Y, Kim S, Lee SM, Kim HU, Ko JM, Lee SH, Yoon SS, Park S (2023). Systematic analysis of disease-linked rare germline variants reveals new classes of cancer predisposing genes.. Genome Med 15, 107. CNIO Publication.
Koh Y, Kim H, Joo SY, Song S, Choi YH, Kim HR, Moon B, Byun J, Hong J, Shin DY, Park S, Lee KH, Lee KT, Lee JK, Park D, Lee SH, Jang JY, Lee H, Kim JA, Yoon SS, Park JK. (2023). Genetic assessment of pathogenic germline alterations in lysosomal genes among Asian patients with pancreatic ductal adenocarcinoma. J Transl Med 21, 730. CNIO Publication.
Kwon HY, Kumar Das R, Jung GT, Lee HG, Lee SH, Berry SN, Tan JKS, Park S, Yang JS, Park S, Baek K, Park KM, Lee JW, Choi YK, Kim KH, Kim S, Kim KP, Kang NY, Kim K, Chang YT (2021). Lipid-Oriented Live-Cell Distinction of B and T Lymphocytes. J Am Chem Soc 143, 5836-5844. CNIO Publication.
Kwon HY, Kumar Das R, Jung GT, Lee HG, Lee SH, Berry SN, Tan JKS, Park S, Yang JS, Park S, Baek K, Park KM, Lee JW, Choi YK, Kim KH, Kim S, Kim KP, Kang NY, Kim K, Chang YT (2021). Lipid-Oriented Live-Cell Distinction of B and T Lymphocytes. J Am Chem Soc 143, 5836-5844. CNIO Publication.
Park S, Supek F, Lehner B (2021). Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers.. Nat Commun 12, 7051. CNIO Publication. Open Access
Herranz-Montoya I, Park S, Djouder N (2021). A comprehensive analysis of prefoldins and their implication in cancer.. iScience 24, 103273. CNIO Publication. Open Access