H12O-CNIO Lung Cancer Clinical Research Unit

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Luis Gonzaga Paz-Ares
Luis Gonzaga Paz-Ares Head of Clinical Research Unit
T +34 (+34) 917 328 000 (Ext )

Staff Scientists

  • María Teresa Agullo
  • Irene Ferrer
  • Rocio García
  • Eva María Garrido
  • Santiago Ponce
  • María del Carmen Riesco

Clinical Investigator

  • María Teresa Muñoz
  • José Luis Solórzano

Post-Doctoral Fellows

  • Juan Manuel Coya
  • Beatriz Soldevilla

Graduate Students

  • Carlos Carretero
  • Santiago García
  • Ángela María Marrugal
  • Ángel Núñez
  • Laura Ojeda
  • Javier Ramos
  • Beatriz Rubio
  • Patricia Yagüe


  • María Cristina Cirauqui
  • Patricia Cozar
  • Mirella Gallego
  • Laura García
  • Beatriz Gil
  • Alicia Luengo
  • Aranzazu Rosado
  • Lorena Ruiz
  • Rocío Suárez

Lung cancer continues to be the most frequent cause of cancer- related deaths worldwide. Our Unit focuses on the study of lung cancer, from fundamental research proposals to other more clinically oriented ones that are closer to solving the problems of lung cancer patients. The two main research areas of our Unit involve : the identification of new molecular biomarkers that can be used in the clinic for diagnostic, prognostic and predictive purposes; and the development of novel treatment strategies that include targeted therapies and immunotherapeutics. For example, we have contributed to elucidating the molecular determinants of EGFR or FGFR oncogenicity and have discovered biomarkers that may guide the efficacy of inhibitors of those receptors in lung cancer. On the other hand, we have developed a patient-derived xenograft (PDX) platform of non-small-cell lung cancers to test new therapeutic strategies. Finally, our Unit has extensive experience in taking new drugs to the clinic ( phase I trials ), as well as in conducting practice-changing phase II/III trials in the fields of precision oncology and immuno-oncology.