Sección de Química Médica

Inicio | Investigación e innovación | Programas Científicos | Programa de Terapias Experimentales | Sección de Química Médica


  • Ana B. García
  • Cristina Ana Gómez
  • Esther González
  • Sonsoles Rodríguez
  • Carmen Varela

Becarios Pre-Doctorales

  • Javier Sánchez

Técnicos de Laboratorio

  • Lucía De Andrés

The Medicinal Chemistry Section is part of the multidisciplinary Experimental Therapeutics Programme (ETP) that is focused on early drug discovery activities. Our aim is to generate advanced chemical compounds that could be further developed into drugs to treat cancer. The Section deals with the design, synthesis, and optimisation of compounds that are characterised in the Biology Section of ETP to evaluate their potency in biological targets, in vitro and in vivo drug-like properties and, finally, to demonstrate their efficacy and mechanism of action in animal models (in vivo proof-of-concept). As a complementary strategy to the classic inhibitors, we also contemplate the degradation of particular targets using different chemical approaches such as the use of proteolysis targeting chimeras (PROTACs). Additionally, we have entered the chemical biology field in order to discover and identify novel drugs and targets from phenotypic screenings. In this regard, we contribute by synthesising high quality chemical tools needed for interrogating the observed phenotype.