Grupo de Complejos Macromoleculares en la Respuesta a Daños en el DNA

Inicio | Investigación e innovación | Programas Científicos | Programa de Biología Estructural | Grupo de Complejos Macromoleculares en la Respuesta a Daños en el DNA

Investigadores

  • Javier Coloma
  • Ana I. Hernández
  • María Ibarra
  • Andrés López
  • Ángel Rivera
  • Marina Serna

Becarios Post-doctorales

  • Sofía Cabezudo
  • María Martínez

Becarios Pre-Doctorales

  • Natalia Cuervo
  • Nayim González

Técnicos de Laboratorio

  • Ana González

Our Group uses cryo-electron microscopy (cryoEM) to determine the 3D structure of large macromolecular complexes of relevance in cancer at high resolution. Structural information, in combination with molecular and cell biology and biochemistry, is then used to propose how these molecules work and increase our understanding of the molecular basis of cancer. Most of our efforts are currently focused on 2 major areas of research: the study of chaperones essential for the activation of several macromolecular complexes relevant in cancer such as those formed by the mTOR kinase, and the study of complexes implicated in the repair of DNA double-strand breaks. In addition, and in collaboration with other groups, we are studying the structure and mechanisms of several amino acid transporters.

Publicaciones

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