Macromolecular Complexes in DNA Damage Response Group

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Research Scientists

  • Javier Coloma
  • Ana I. Hernández
  • Andrés López
  • Ángel Rivera
  • Marina Serna

Post-Doctoral Fellows

  • Ana González
  • María Ibarra
  • María Martínez

Graduate Students

  • Carmen García
  • Nayim González

Our Group uses cryo-electron microscopy (cryoEM) to determine the 3D structure of large macromolecular complexes of relevance in cancer. Structural information, in combination with molecular and cell biology and biochemistry, is then used to propose how these molecules work and increase our understanding of the molecular basis of cancer. Most of our efforts are currently focused on 2 major areas of research: i) the study of chaperones essential for the activation of several macromolecular complexes relevant in cancer such as mTORC1; and ii) the study of complexes implicated in the repair of DNA damage and in genomic instability. In collaboration with other groups, we are also studying the structure and mechanisms of several amino acid transporters, as well as the mechanisms that regulate microtubule nucleation for the assembly of the mitotic spindle.