Macromolecular Complexes in DNA Damage Response Group

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Staff Scientists

  • Javier Coloma
  • Ana I. Hernández
  • María Ibarra
  • Andrés López
  • Ángel Rivera
  • Marina Serna

Post-Doctoral Fellows

  • Sofía Cabezudo
  • María Martínez
  • Alba Ruiz

Graduate Students

  • Natalia Cuervo
  • Nayim González

Technicians

  • Paloma Escudero
  • Ana González

Our current work dedicates special attention to study RUVBL1 and RUVBL2, 2 highly conserved AAA+ ATPases that are essential for several cellular processes relevant in cancer, including Fanconi anaemia, chromatin remodelling, nonsense-mediated mRNA decay (NMD), and the assembly and activation of large macromolecular complexes such as the those formed by mTOR and ATR kinases. Interestingly, RUVBL1-RUVBL2 inhibitors show anti-oncogenic potential, and cancer cells with high mTOR activity are dependent on the functions of RUVBL1-RUVBL2 for survival. How RUVBL1 and RUVBL2 perform their functions is only partially understood. Our work provides novel structural and mechanistic understanding of how these ATPases work, which will be useful for exploring new ways to target these proteins. For this, we combine biochemistry, and molecular and cell biology with cryo-electron microscopy methods that allow us to visualise individual macromolecular complexes and to resolve their structure at high resolution.

Publications

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