Macromolecular Complexes in DNA Damage Response Group

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Staff Scientists

  • Javier Coloma
  • Ana I. Hernández
  • María Ibarra
  • Andrés López
  • Ángel Rivera
  • Marina Serna

Post-Doctoral Fellows

  • Sofía Cabezudo
  • María Martínez

Graduate Students

  • Natalia Cuervo
  • Carmen García
  • Nayim González

Technicians

  • Ana González

Our Group uses cryo-electron microscopy (cryoEM) to determine the 3D structure of large macromolecular complexes of relevance in cancer at high resolution. Structural information, in combination with molecular and cell biology and biochemistry, is then used to propose how these molecules work and increase our understanding of the molecular basis of cancer. Most of our efforts are currently focused on 2 major areas of research: the study of chaperones essential for the activation of several macromolecular complexes relevant in cancer such as those formed by the mTOR kinase, and the study of complexes implicated in the repair of DNA double-strand breaks. In addition, and in collaboration with other groups, we are studying the structure and mechanisms of several amino acid transporters.

Publications

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