Macromolecular Complexes in DNA Damage Response Group

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Staff Scientists

  • Javier Coloma
  • Ana I. Hernández
  • María Ibarra
  • Andrés López
  • Ángel Rivera
  • Marina Serna

Post-Doctoral Fellows

  • Sofía Cabezudo
  • María Martínez
  • Alba Ruiz

Graduate Students

  • Natalia Cuervo
  • Nayim González


  • Paloma Escudero
  • Ana González

Our key mission is to provide in-depth structural and molecular understanding of how macromolecular complexes implicated in cancer work. This information is essential to comprehend why and how some proteins are involved in the development of cancer. This fundamental knowledge is the basis to start the search for potential strategies to interfere with the function of these macromolecules, either as therapeutic potential or research tool. To accomplish this, we make use of several biochemical and molecular biology tools in combination with cryo-electron microscopy (cryo-EM). Cryo-EM is used to visualise large macromolecular complexes, and to observe how they function. Two main objectives drive our current research: (i) the study of macromolecular complexes that function in the cellular response to DNA damage; and (ii) an HSP90 co-chaperone system implicated in the assembly, activation and regulation of several complexes that are essential for cancer progression. In addition, we also address other relevant questions for other human diseases, in collaboration with other groups.