Óscar Llorca Group Leader
T +34 (+34) 917 328 000 (Ext 3000)
ollorca@cnio.es

Publications

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• Calugaru K, Yu EY, Huang S, González-Rodríguez N, Coloma J, Lue NF. (2025). The yeast CST and Polα/primase complexes act in concert to ensure proper telomere maintenance and protection. Nucleic Acids Res 53, gkaf245. CNIO Publication.
• Palacios-Abella A, López-Perrote A, Boskovic J, Fonseca S, Úrbez C, Rubio V, Llorca O, Alabadí D. (2025). The structure of the R2T complex reveals a different architecture from the related HSP90 cochaperone R2TP. Structure 33, 740-752. CNIO Publication.
• Brito C, Serna M, Guerra P, Llorca O, Surrey T. (2024). Transition of human γ-tubulin ring complex into a closed conformation during microtubule nucleation. Science 383, 870-876. CNIO Publication.
• Rullo-Tubau J, Martinez-Molledo M, Bartoccioni P, Puch-Giner I, Arias Á, Saen-Oon S, Stephan-Otto Attolini C, Artuch R, Díaz L, Guallar V, Errasti-Murugarren E, Palacín M, Llorca O. (2024). Structure and mechanisms of transport of human Asc1/CD98hc amino acid transporter. Nat Commun 15, 2986. CNIO Publication. Open Access
• Serna M, Zimmermann F, Vineethakumari Ch, Gonzalez-Rodriguez N, Llorca O, Lüders J (2024). CDK5RAP2 activates microtubule nucleator gTuRCby facilitating template formation and actin release. Dev Cell 59, 3175-3188. CNIO Publication.
• García- Martín C, López-Perrote A, Boskovic J , Llorca O (2024). Mechanism of allosteric inhibition of RUVBL1-RUVBL2 ATPase by the small molecule CB-6644. Cell Rep Phys Sci 5, 101982. CNIO Publication.
• López-Perrote A, Serna M, Llorca O. (2024). Maturation and Assembly of mTOR Complexes by the HSP90-R2TP-TTT Chaperone System: Molecular Insights and Mechanisms. Subcell Biochem 104, 459-483. CNIO Publication.
• Coloma J, Gonzalez-Rodriguez N, Balaguer FA, Gmurczyk k, Aicart-Ramos C, Nuero OM, Luque-Ortega JR, Calugaru K, Lue NF, Moreno-Herrero F, Llorca O (2023). Molecular architecture and oligomerization of Candida glabrata Cdc13 underpin its telomeric DNA-binding and unfolding activity. Nucleic Acids Res 51, 668-686. CNIO Publication. Open Access
• Bragança Sara De, Aicart-Ramos Clara, Arribas-Bosacoma Raquel, Fortes P, Llorca O, Moreno-Herrero F (2023). APLF and long non-coding RNA NIHCOLE promote stable DNA synapsis in non-homologous end joining. Cell Reports 42, 111917. CNIO Publication. Open Access
• Serna M, González-Corpas A, Cabezudo S, López-Perrote A, Degliesposti G, Zarzuela E, Skehel JM, Muñoz J, Llorca O (2022). CryoEM of RUVBL1-RUVBL2-ZNHIT2, a complex that interacts with pre-mRNA-processing-splicing factor 8. Nucleic Acids Res 50, 1128-1146. CNIO Publication. Open Access
• Rivera-Calzada A, Arribas-Bosacoma R, Ruiz-Ramos A, Escudero-Bravo P, Boskovic J, Fernandez-Leiro R, Oliver AW, Pearl LH, Llorca O. (2022). Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus.. Nat Commun 13, 7062. CNIO Publication. Open Access
• Rullo-Tubau J, Bartoccioni P, Llorca O, Errasti-Murugarren E, Palacín M. (2022). HATs meet structural biology. Curr Opin Struc Biol 74, 102389. CNIO Publication.
• Rivera Calzada A, Famelis Nikolaos, Llorca O, Geibel S (2021). Type VII secretion systems: structure, functions and transport models. Nat Rev Microbiol 19, 567-584. CNIO Publication.
• Unfried JP, Marín-Baquero M, Rivera-Calzada Á, Razquin N, Martín-Cuevas EM, de Bragança S, Aicart-Ramos C, McCoy C, Prats-Mari L, Arribas-Bosacoma R, Lee L, Caruso S, Zucman-Rossi J, Sangro B, Williams G, Moreno-Herrero F, Llorca O, Lees-Miller SP, Fortes P (2021). Long noncoding RNA NIHCOLE promotes ligation efficiency of DNA double-strand breaks in hepatocellular carcinoma.. Cancer Res 81, 4910-4925. CNIO Publication.
• Rodriguez CF, Escudero-Bravo P, Díaz L, Bartoccioni P, García-Martín C, Gilabert JG, Boskovic J, Guallar V, Errasti-Murugarren E, Llorca O, Palacín M (2021). Structural basis for substrate specificity of heteromeric transporters of neutral amino acids.. Proc Natl Acad Sci USA 118, e2113573118. CNIO Publication.
• Pal M, Muñoz-Hernandez H, Bjorklund D, Zhou L, Degliesposti G, Skehel JM, Hesketh EL, Thompson RF, Pearl LH, Llorca O, Prodromou C (2021). Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone. Cell Reports 36, 109317. CNIO Publication. Open Access
• Fresno C, García-Arriaza J, Martínez-Cano S, Heras-Murillo I, Jarit-Cabanillas A, Amores-Iniesta J, Brandi P, Dunphy G, Suay-Corredera S, Pricolo MR, Vicente N, López-Perrote A, Cabezudo S, González-Corpas A, LLorca O, Alegre-Cebollada J, Garaigorta U, Gastamiza P, Esteban M, Sancho D (2021). The Bacterial Mucosal Immunotherapy MV130 Protects Against SARS-CoV-2 Infection and Improves COVID-19 Vaccines Immunogenicity. Front Inmmunol 12, 748103. CNIO Publication. Open Access
• Dauden MI, López-Perrote A, Llorca O (2021). RUVBL1-RUVBL2 AAA-ATPase: a versatile scaffold for multiple complexes and functions. Curr Opin Struc Biol 19, 78-85. CNIO Publication.
• Zimmermann F, Serna M, Ezquerra A, Fernandez-Leiro R, Llorca O, Luders J (2020). Assembly of the asymmetric human ?-tubulin ring complex by RUVBL1-RUVBL2 AAA ATPase. Sci Adv 6, eabe0894. CNIO Publication. Open Access
• Acebrón I, Righetto RD, Schoenherr C, Buhr S, Redondo P, Culley J, Rodríguez CF, Daday C, Biyani N, Llorca O, Byron A, Chami M, Gräter F, Boskovic J, Margaret C Frame, Stahlberg H, Lietha D (2020). Structural basis of Focal Adhesion Kinase activation on lipid membranes.. EMBO J 39, e104743. CNIO Publication. Open Access
• López-Perrote A , NHug N, González-Corpas A, Rodríguez CF , Serna M, García-Martín C , Boskovic J, Fernandez-Leiro R, Caceres JF , Llorca O (2020). Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM. Elife 9, e63042. CNIO Publication. Open Access
• Dauden M, López-Perrote A, Llorca O (2020). RUVBL1–RUVBL2 AAA-ATPase: a versatile scaffold for multiple complexes and functions. Curr Opin Struc Biol 67, 78-85. CNIO Publication.
• Rodríguez CF, Pal M, Muñoz-Hernandez H, Pearl LH, Llorca O (2020). Modeling of a 14 kDa RUVBL2-Binding Domain with Medium Resolution Cryo-EM Density.. J Chem Inf Model 60, 2541-2551. CNIO Publication.
• Rodríguez Carlos F, LLorca O (2020). RPAP3 C-Terminal Domain: A Conserved Domain for the Assembly of R2TP Co-Chaperone Complexes. Cells 9, E1139. CNIO Publication. Open Access