Cells need to adjust their growth rate and metabolism in response to the availability of resources in their environment. This mechanism utilises evolutionarily conserved multi-component protein complexes to detect and transduce extra- and intracellular information to specific protein effectors. Correct coordination and function of these complexes is essential in human physiology, as defects have been associated with cancer, metabolic diseases and ageing.

Using state of the art cryo-electron microscopy, biochemistry and cell biology, our Group investigates the molecular mechanisms by which specific nutrients, growth factors, and other signals regulate cell growth and metabolism. By understanding how the protein complexes involved work, we aim to help in the development of novel and improved therapeutic strategies for the prevention and treatment of different types of cancer and associated diseases.