All cells need to adjust their growth rate and metabolism to the availability of resources in their environment. To do so, evolutionarily conserved multi-component protein complexes detect and transduce extra- and intracellular information to specific protein effectors. Proper coordination and function of these complexes are essential for health, as defects have been associated with cancer, metabolic diseases, and ageing.

Using state-of-the-art cryo-electron microscopy, biochemistry and cell biology, our Group investigates the molecular mechanisms by which specific nutrients, growth factors, and other signals regulate cell growth and metabolism. By understanding how the involved protein complexes work, we aim to characterise the molecular basis of basic cell biology pathways and help in the development of novel and improved therapeutic strategies for the prevention and treatment of different types of cancer and associated diseases.